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    Pcsk2 proprotein convertase subtilisin/kexin type 2 [ Mus musculus (house mouse) ]

    Gene ID: 18549, updated on 25-Sep-2017
    Official Symbol
    Pcsk2provided by MGI
    Official Full Name
    proprotein convertase subtilisin/kexin type 2provided by MGI
    Primary source
    MGI:MGI:97512
    See related
    Ensembl:ENSMUSG00000027419 Vega:OTTMUSG00000003089
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PC2; Nec2; SPC2; Nec-2; Phpp-2; AI839700; 6330411F23Rik
    Expression
    Biased expression in cortex adult (RPKM 46.1), frontal lobe adult (RPKM 33.5) and 4 other tissues See more
    Orthologs
    Location:
    2 G1; 2 70.89 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (143546133..143816284)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (143371869..143642020)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33599 Neighboring gene high mobility group protein B1 pseudogene Neighboring gene proprotein convertase subtilisin/kexin type 2, opposite strand 1 Neighboring gene proprotein convertase subtilisin/kexin type 2, opposite strand 2 Neighboring gene 40S ribosomal protein S13 pseudogene Neighboring gene beaded filament structural protein 1, in lens-CP94 Neighboring gene predicted gene, 33648

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    enkephalin processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    insulin processing ISO
    Inferred from Sequence Orthology
    more info
     
    islet amyloid polypeptide processing ISO
    Inferred from Sequence Orthology
    more info
     
    nervous system development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    peptide hormone processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptide hormone processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptide hormone processing ISO
    Inferred from Sequence Orthology
    more info
     
    protein autoprocessing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    neuroendocrine convertase 2
    Names
    KEX2-like endoprotease 2
    NEC 2
    prohormone convertase 2
    proprotein convertase 2
    NP_032818.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008792.4NP_032818.1  neuroendocrine convertase 2 precursor

      See identical proteins and their annotated locations for NP_032818.1

      Status: VALIDATED

      Source sequence(s)
      AK158598, AL807801, BC057348
      Consensus CDS
      CCDS16810.1
      UniProtKB/Swiss-Prot
      P21661
      UniProtKB/TrEMBL
      Q547J8
      Related
      ENSMUSP00000028905.9, OTTMUSP00000002995, ENSMUST00000028905.9, OTTMUST00000006367
      Conserved Domains (4) summary
      cd04059
      Location:121417
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:157434
      Peptidase_S8; Subtilase family
      pfam01483
      Location:503590
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:32108
      S8_pro-domain; Peptidase S8 pro-domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      143546133..143816284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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