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    mig-5 Segment polarity protein dishevelled homolog mig-5 [ Caenorhabditis elegans ]

    Gene ID: 174317, updated on 9-Apr-2017
    Gene symbol
    mig-5
    Gene description
    Segment polarity protein dishevelled homolog mig-5
    Primary source
    WormBase:WBGene00003241
    Locus tag
    CELE_T05C12.6
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    See mig-5 in Map Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (8182478..8185008, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene DYnein Light chain (Tctex type) Neighboring gene T-complex protein 1 subunit alpha Neighboring gene hypothetical protein

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling adaptor activity IC
    Inferred by Curator
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Wnt signaling pathway, planar cell polarity pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Wnt signaling pathway, regulating spindle positioning IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Wnt signaling pathway, regulating spindle positioning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    asymmetric cell division IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell fate specification involved in pattern specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell migration IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryo development ending in birth or egg hatching IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    embryonic digestive tract morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endodermal cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    epidermis morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of mitotic spindle orientation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    establishment of mitotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inductive cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    left/right axis specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oviposition IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    positive regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of establishment or maintenance of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of establishment or maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction involved in regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    Segment polarity protein dishevelled homolog mig-5
    NP_001022316.1
    • Confirmed by transcript evidence
    NP_001022317.1
    • Confirmed by transcript evidence
    NP_001022318.1
    • Confirmed by transcript evidence

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8182478..8185008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027145.2NP_001022316.1  Segment polarity protein dishevelled homolog mig-5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022316.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22227
      Conserved Domains (3) summary
      smart00021
      Location:992
      DAX; Domain present in Dishevelled and axin
      cd00992
      Location:237305
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04438
      Location:419501
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    2. NM_001027147.2NP_001022318.1  Segment polarity protein dishevelled homolog mig-5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022318.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22227
      Conserved Domains (3) summary
      smart00021
      Location:992
      DAX; Domain present in Dishevelled and axin
      cd00992
      Location:237294
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04438
      Location:378460
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    3. NM_001027146.2NP_001022317.1  Segment polarity protein dishevelled homolog mig-5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022317.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22227
      Conserved Domains (3) summary
      smart00021
      Location:992
      DAX; Domain present in Dishevelled and axin
      cd00992
      Location:237305
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04438
      Location:419501
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
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