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    Pdgfb platelet derived growth factor, B polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 18591, updated on 21-May-2017
    Official Symbol
    Pdgfbprovided by MGI
    Official Full Name
    platelet derived growth factor, B polypeptideprovided by MGI
    Primary source
    MGI:MGI:97528
    See related
    Ensembl:ENSMUSG00000000489
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sis; PDGF-B
    Orthologs
    Location:
    15 E1; 15 37.85 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (79995865..80024778, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (79826304..79845238, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D730005E14 gene Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 Neighboring gene chromobox 7 Neighboring gene microRNA 7213 Neighboring gene predicted gene, 41361 Neighboring gene predicted gene, 41362 Neighboring gene small nucleolar RNA, C/D box 83B Neighboring gene ribosomal protein L3

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chemoattractant activity ISO
    Inferred from Sequence Orthology
    more info
     
    collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    platelet-derived growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    platelet-derived growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    platelet-derived growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    superoxide-generating NADPH oxidase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    activation of protein kinase B activity ISO
    Inferred from Sequence Orthology
    more info
     
    activation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    blood vessel development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    blood vessel morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    blood vessel morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    branching involved in salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac vascular smooth muscle cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to mycophenolic acid ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial cell proliferation involved in salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    eye photoreceptor cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glial cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    interleukin-18-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    metanephric glomerular endothelium development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    metanephric glomerular mesangial cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metanephric glomerular mesangial cell proliferation involved in metanephros development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of blood vessel diameter TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of phosphatidylinositol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of platelet activation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of pri-miRNA transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of vascular smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    paracrine signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    platelet-derived growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    platelet-derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of calcium ion import ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of endothelial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glomerular filtration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of glomerular mesangial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of hepatic stellate cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of hepatic stellate cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of hyaluronan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of metanephric mesenchymal cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitotic cell cycle, embryonic IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphatidylinositol 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of pri-miRNA transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vascular smooth muscle cell dedifferentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vascular smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vasoconstriction TAS
    Traceable Author Statement
    more info
    PubMed 
    protein kinase C signaling ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to wounding ISO
    Inferred from Sequence Orthology
    more info
     
    retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retina vasculature development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    substrate-dependent cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    platelet-derived growth factor subunit B
    Names
    PDGF subunit B
    PDGF-2
    c-sis
    platelet-derived growth factor B chain
    platelet-derived growth factor beta polypeptide
    proto-oncogene c-Sis

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011057.3NP_035187.2  platelet-derived growth factor subunit B precursor

      See identical proteins and their annotated locations for NP_035187.2

      Status: PROVISIONAL

      Source sequence(s)
      BC053430
      Consensus CDS
      CCDS27656.1
      UniProtKB/Swiss-Prot
      P31240
      UniProtKB/TrEMBL
      A0A0R4IZW4
      Related
      ENSMUSP00000000500.6, ENSMUST00000000500.6
      Conserved Domains (2) summary
      pfam00341
      Location:97180
      PDGF; PDGF/VEGF domain
      pfam04692
      Location:2193
      PDGF_N; Platelet-derived growth factor, N terminal region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      79995865..80024778 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316502.1XP_017171991.1  platelet-derived growth factor subunit B isoform X1

      UniProtKB/Swiss-Prot
      P31240
      UniProtKB/TrEMBL
      A0A0R4IZW4
      Conserved Domains (2) summary
      pfam00341
      Location:97180
      PDGF; PDGF/VEGF domain
      pfam04692
      Location:2193
      PDGF_N; Platelet-derived growth factor, N terminal region
    2. XM_006520592.3XP_006520655.1  platelet-derived growth factor subunit B isoform X2

      Conserved Domains (1) summary
      pfam00341
      Location:34117
      PDGF; PDGF/VEGF domain
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