Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 67155, updated on 8-Dec-2016
    Official Symbol
    Smarca2provided by MGI
    Official Full Name
    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2provided by MGI
    Primary source
    MGI:MGI:99603
    See related
    Ensembl:ENSMUSG00000024921 Vega:OTTMUSG00000040069
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    brm; Snf2l2; brahma; SNF2alpha; 2610209L14Rik
    Orthologs
    Location:
    19 C1; 19 21.17 cM
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (26605088..26778321)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (26679650..26852811)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 34808 Neighboring gene predicted gene, 41828 Neighboring gene predicted gene 20616 Neighboring gene RIKEN cDNA 4931403E22 gene Neighboring gene uncharacterized LOC108168409 Neighboring gene vaccinia related kinase 1 pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    histone binding IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity, acting on acid anhydrides IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    aortic smooth muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromatin organization TAS
    Traceable Author Statement
    more info
    PubMed 
    chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    nucleosome assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    BAF-type complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SWI/SNF complex ISO
    Inferred from Sequence Orthology
    more info
     
    SWI/SNF complex TAS
    Traceable Author Statement
    more info
    PubMed 
    intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nBAF complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    npBAF complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    probable global transcription activator SNF2L2
    Names
    ATP-dependent helicase SMARCA2
    BAF190B
    BRG1-associated factor 190B
    SNF2-alpha
    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2
    protein brahma homolog
    subunit of the SWI/SNF chromatin remodeling complex

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347439.1NP_001334368.1  probable global transcription activator SNF2L2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC118472, BC075641
      Consensus CDS
      CCDS84428.1
    2. NM_011416.2NP_035546.2  probable global transcription activator SNF2L2 isoform 1

      See identical proteins and their annotated locations for NP_035546.2

      Status: VALIDATED

      Source sequence(s)
      BC075641, BQ560773, CB522063
      Consensus CDS
      CCDS29720.1
      UniProtKB/Swiss-Prot
      Q6DIC0
      UniProtKB/TrEMBL
      F2Z4A9
      Related
      ENSMUSP00000025862, OTTMUSP00000058197, ENSMUST00000025862, OTTMUST00000104062
      Conserved Domains (10) summary
      cd05516
      Location:13931499
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:601643
      BRK; domain in transcription and CHROMO domain helicases
      smart00573
      Location:447519
      HSA; domain in helicases and associated with SANT domains
      cd00046
      Location:755894
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:7381033
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:10601175
      Helicase_C; Helicase conserved C-terminal domain
      pfam08880
      Location:173207
      QLQ; QLQ
      pfam12067
      Location:99199
      Sox_C_TAD; Sox C-terminal transactivation domain
      pfam14619
      Location:12701337
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
      cl02556
      Location:13441439
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    3. NM_026003.2NP_080279.1  probable global transcription activator SNF2L2 isoform 2

      See identical proteins and their annotated locations for NP_080279.1

      Status: VALIDATED

      Source sequence(s)
      AI842968, AK009309, AK011935, BY262171
      Consensus CDS
      CCDS37945.1
      UniProtKB/TrEMBL
      Q9D007
      Related
      ENSMUSP00000108256, ENSMUST00000112637
      Conserved Domains (2) summary
      cd05516
      Location:46152
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      cl02556
      Location:259
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      26605088..26778321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527282.3XP_006527345.1  

      See identical proteins and their annotated locations for XP_006527345.1

      UniProtKB/TrEMBL
      H3BLH0
      Related
      ENSMUSP00000135784, OTTMUSP00000058196, ENSMUST00000176030, OTTMUST00000104061
      Conserved Domains (10) summary
      cd05516
      Location:13931517
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:601643
      BRK; domain in transcription and CHROMO domain helicases
      smart00573
      Location:447519
      HSA; domain in helicases and associated with SANT domains
      cd00046
      Location:755894
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:7381033
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:10601175
      Helicase_C; Helicase conserved C-terminal domain
      pfam08880
      Location:173207
      QLQ; QLQ
      pfam12067
      Location:99199
      Sox_C_TAD; Sox C-terminal transactivation domain
      pfam14619
      Location:12701337
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
      cl02556
      Location:13441430
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    2. XM_006527284.2XP_006527347.1  

      See identical proteins and their annotated locations for XP_006527347.1

      UniProtKB/TrEMBL
      H3BLH0
      Conserved Domains (10) summary
      cd05516
      Location:13931517
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:601643
      BRK; domain in transcription and CHROMO domain helicases
      smart00573
      Location:447519
      HSA; domain in helicases and associated with SANT domains
      cd00046
      Location:755894
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:7381033
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:10601175
      Helicase_C; Helicase conserved C-terminal domain
      pfam08880
      Location:173207
      QLQ; QLQ
      pfam12067
      Location:99199
      Sox_C_TAD; Sox C-terminal transactivation domain
      pfam14619
      Location:12701337
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
      cl02556
      Location:13441430
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    3. XM_006527283.3XP_006527346.1  

      See identical proteins and their annotated locations for XP_006527346.1

      UniProtKB/TrEMBL
      H3BLH0
      Conserved Domains (10) summary
      cd05516
      Location:13931517
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:601643
      BRK; domain in transcription and CHROMO domain helicases
      smart00573
      Location:447519
      HSA; domain in helicases and associated with SANT domains
      cd00046
      Location:755894
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:7381033
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:10601175
      Helicase_C; Helicase conserved C-terminal domain
      pfam08880
      Location:173207
      QLQ; QLQ
      pfam12067
      Location:99199
      Sox_C_TAD; Sox C-terminal transactivation domain
      pfam14619
      Location:12701337
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
      cl02556
      Location:13441430
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    4. XM_006527281.3XP_006527344.1  

      See identical proteins and their annotated locations for XP_006527344.1

      UniProtKB/TrEMBL
      H3BLH0
      Related
      ENSMUSP00000097135, OTTMUSP00000058198, ENSMUST00000099537, OTTMUST00000104063
      Conserved Domains (10) summary
      cd05516
      Location:13931517
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:601643
      BRK; domain in transcription and CHROMO domain helicases
      smart00573
      Location:447519
      HSA; domain in helicases and associated with SANT domains
      cd00046
      Location:755894
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:7381033
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:10601175
      Helicase_C; Helicase conserved C-terminal domain
      pfam08880
      Location:173207
      QLQ; QLQ
      pfam12067
      Location:99199
      Sox_C_TAD; Sox C-terminal transactivation domain
      pfam14619
      Location:12701337
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
      cl02556
      Location:13441430
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    5. XM_006527285.2XP_006527348.1  

      See identical proteins and their annotated locations for XP_006527348.1

      UniProtKB/TrEMBL
      F2Z4A9
      Conserved Domains (10) summary
      cd05516
      Location:13931499
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:601643
      BRK; domain in transcription and CHROMO domain helicases
      smart00573
      Location:447519
      HSA; domain in helicases and associated with SANT domains
      cd00046
      Location:755894
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:7381033
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:10601175
      Helicase_C; Helicase conserved C-terminal domain
      pfam08880
      Location:173207
      QLQ; QLQ
      pfam12067
      Location:99199
      Sox_C_TAD; Sox C-terminal transactivation domain
      pfam14619
      Location:12701337
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
      cl02556
      Location:13441439
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    6. XM_006527286.1XP_006527349.1  

      Conserved Domains (10) summary
      cd05516
      Location:13171441
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:525567
      BRK; domain in transcription and CHROMO domain helicases
      smart00573
      Location:371443
      HSA; domain in helicases and associated with SANT domains
      cd00046
      Location:679818
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:662957
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:9841099
      Helicase_C; Helicase conserved C-terminal domain
      pfam08880
      Location:97131
      QLQ; QLQ
      pfam12067
      Location:23123
      Sox_C_TAD; Sox C-terminal transactivation domain
      pfam14619
      Location:11941261
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
      cl02556
      Location:12681354
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    7. XM_017318275.1XP_017173764.1  

      UniProtKB/TrEMBL
      H3BK47
      Conserved Domains (2) summary
      cd05516
      Location:86192
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      cl02556
      Location:3799
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    8. XM_017318278.1XP_017173767.1  

      UniProtKB/TrEMBL
      Q9D007
      Related
      ENSMUSP00000146924, OTTMUSP00000075843, ENSMUST00000208751, OTTMUST00000145589
      Conserved Domains (2) summary
      cd05516
      Location:46152
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      cl02556
      Location:259
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    9. XM_006527288.2XP_006527351.1  

      See identical proteins and their annotated locations for XP_006527351.1

      UniProtKB/TrEMBL
      H3BK47
      Related
      ENSMUSP00000146493, OTTMUSP00000075844, ENSMUST00000207054, OTTMUST00000145590
      Conserved Domains (2) summary
      cd05516
      Location:86192
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      cl02556
      Location:3799
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    10. XM_006527291.2XP_006527354.1  

      See identical proteins and their annotated locations for XP_006527354.1

      UniProtKB/TrEMBL
      Q9D007
      Related
      ENSMUSP00000146890, OTTMUSP00000058208, ENSMUST00000208589, OTTMUST00000104080
      Conserved Domains (2) summary
      cd05516
      Location:46152
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      cl02556
      Location:259
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    11. XM_006527289.2XP_006527352.1  

      See identical proteins and their annotated locations for XP_006527352.1

      UniProtKB/TrEMBL
      H3BK47
      Related
      ENSMUSP00000135248, OTTMUSP00000075853, ENSMUST00000176475, OTTMUST00000145605
      Conserved Domains (2) summary
      cd05516
      Location:86192
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      cl02556
      Location:3799
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    12. XM_017318276.1XP_017173765.1  

      UniProtKB/TrEMBL
      Q9D007
      Conserved Domains (2) summary
      cd05516
      Location:46152
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      cl02556
      Location:259
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    13. XM_017318277.1XP_017173766.1  

      UniProtKB/TrEMBL
      Q9D007
      Related
      ENSMUSP00000146875, OTTMUSP00000075858, ENSMUST00000208091, OTTMUST00000145610
      Conserved Domains (2) summary
      cd05516
      Location:46152
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      cl02556
      Location:259
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

    RNA

    1. XR_386502.2 RNA Sequence

    Support Center