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    ESR1 estrogen receptor 1 [ Homo sapiens (human) ]

    Gene ID: 2099, updated on 15-Oct-2017
    Official Symbol
    ESR1provided by HGNC
    Official Full Name
    estrogen receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:3467
    See related
    Ensembl:ENSG00000091831 MIM:133430; Vega:OTTHUMG00000016103
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ER; ESR; Era; ESRA; ESTRR; NR3A1
    Summary
    This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]
    Orthologs
    Location:
    6q25.1-q25.2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (151654148..152103274)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (152011631..152424409)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene acidic residue methyltransferase 1 Neighboring gene coiled-coil domain containing 170 Neighboring gene uncharacterized LOC107986528 Neighboring gene RNA, U6 small nuclear 813, pseudogene Neighboring gene uncharacterized LOC107986529 Neighboring gene spectrin repeat containing nuclear envelope protein 1 Neighboring gene SYNE1 antisense RNA 1 Neighboring gene RNA, 5S ribosomal pseudogene 223

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Estrogen resistance
    MedGen: C1851467 OMIM: 615363 GeneReviews: Not available
    Compare labs
    Familial cancer of breast Compare labs
    Migraine
    MedGen: C0149931 OMIM: 157300 GeneReviews: Not available
    Compare labs
    Myocardial infarction 1
    MedGen: C1838021 OMIM: 608446 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia.
    NHGRI GWA Catalog
    Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium.
    NHGRI GWA Catalog
    Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure.
    NHGRI GWA Catalog
    Genetic variants associated with breast size also influence breast cancer risk.
    NHGRI GWA Catalog
    Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
    NHGRI GWA Catalog
    Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer.
    NHGRI GWA Catalog
    Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1.
    NHGRI GWA Catalog
    Genome-wide association study identifies five new breast cancer susceptibility loci.
    NHGRI GWA Catalog
    Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk.
    NHGRI GWA Catalog
    Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer.
    NHGRI GWA Catalog
    Genome-wide association study of alcohol dependence.
    NHGRI GWA Catalog
    Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25.
    NHGRI GWA Catalog
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    NHGRI GWA Catalog
    GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
    NHGRI GWA Catalog
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    NHGRI GWA Catalog
    Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
    NHGRI GWA Catalog
    Multiple genetic loci for bone mineral density and fractures.
    NHGRI GWA Catalog
    New sequence variants associated with bone mineral density.
    NHGRI GWA Catalog
    Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    NHGRI GWA Catalog
    Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env 17beta-estradiol (17beta-E2) protects human neuroblastoma cells from cell death elicited by HIV-1 gp120; estrogen receptor antagonists antagonize 17beta-E2-mediated inhibition gp120-induced cell death PubMed
    Tat tat HIV-1 Tat 47-59 peptide downregulates gene expression of estrogen receptor 1 (ESR1) in U-937 macrophages PubMed
    matrix gag HIV-1 MA upregulates ESR1 mRNA expression in HepG2 cells PubMed
    gag HIV-1 MA upregulates ESR1 gene expression in HepG2 cells PubMed

    Go to the HIV-1, Human Interaction Database

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      FOXA1 transcription factor network, organism-specific biosystem
      FOXA1 transcription factor network
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      FOXM1 transcription factor network, organism-specific biosystem
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      LKB1 signaling events, organism-specific biosystem
      LKB1 signaling events
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    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
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    • Nuclear Receptor transcription pathway, organism-specific biosystem (from REACTOME)
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    • Plasma membrane estrogen receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      Plasma membrane estrogen receptor signaling, organism-specific biosystem
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    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ51616, FLJ51617, FLJ77952, MGC157708, MGC157709, DKFZp686N23123

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    TBP-class protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    TFIIB-class transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    estrogen receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    estrogen receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    estrogen receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    estrogen receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    estrogen response element binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    nitric-oxide synthase regulator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    steroid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    steroid hormone receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    androgen metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    antral ovarian follicle growth IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to estradiol stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to estradiol stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to estrogen stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin remodeling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    epithelial cell development IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial cell proliferation involved in mammary gland duct elongation IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular estrogen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular estrogen receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    intracellular steroid hormone receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    mammary gland alveolus development IEA
    Inferred from Electronic Annotation
    more info
     
    mammary gland branching involved in pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of production of miRNAs involved in gene silencing by miRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phospholipase C-activating G-protein coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of RNA polymerase II transcriptional preinitiation complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of phospholipase C activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    prostate epithelial cord elongation IEA
    Inferred from Electronic Annotation
    more info
     
    protein deubiquitination TAS
    Traceable Author Statement
    more info
     
    protein localization to chromatin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of Wnt signaling pathway TAS
    Traceable Author Statement
    more info
     
    regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of branching involved in prostate gland morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of intracellular estrogen receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    regulation of toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    regulation of transcription, DNA-templated NAS
    Non-traceable Author Statement
    more info
    PubMed 
    response to estradiol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to estrogen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    stem cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription initiation from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    uterus development IEA
    Inferred from Electronic Annotation
    more info
     
    vagina development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcriptional preinitiation complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptionally active chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    estrogen receptor
    Names
    E2 receptor alpha
    ER-alpha
    estradiol receptor
    estrogen nuclear receptor alpha
    estrogen receptor alpha E1-E2-1-2
    estrogen receptor alpha E1-N2-E2-1-2
    nuclear receptor subfamily 3 group A member 1
    oestrogen receptor alpha

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008493.2 RefSeqGene

      Range
      155989..451584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000125.3NP_000116.2  estrogen receptor isoform 1

      See identical proteins and their annotated locations for NP_000116.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses the most proximal promoter, and encodes isoform 1. Variants 1-4 all encode the same isoform 1.
      Source sequence(s)
      AL078582, AL356311, BC128573, BE084831
      Consensus CDS
      CCDS5234.1
      UniProtKB/Swiss-Prot
      P03372
      UniProtKB/TrEMBL
      G4XH65
      Related
      ENSP00000206249.3, OTTHUMP00000017718, ENST00000206249.7, OTTHUMT00000043308
      Conserved Domains (4) summary
      cd06949
      Location:310547
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:180261
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42181
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:556595
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    2. NM_001122740.1NP_001116212.1  estrogen receptor isoform 1

      See identical proteins and their annotated locations for NP_001116212.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses a different promoter, compared to variant 1. Variants 1-4 all encode the same isoform 1.
      Source sequence(s)
      AL078582, BC128573, BE084831, U68067
      Consensus CDS
      CCDS5234.1
      UniProtKB/Swiss-Prot
      P03372
      UniProtKB/TrEMBL
      G4XH65, Q9UBT1
      Related
      ENSP00000387500.1, ENST00000443427.5
      Conserved Domains (4) summary
      cd06949
      Location:310547
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:180261
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42181
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:556595
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    3. NM_001122741.1NP_001116213.1  estrogen receptor isoform 1

      See identical proteins and their annotated locations for NP_001116213.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses a different promoter, compared to variant 1. Variants 1-4 all encode the same isoform 1.
      Source sequence(s)
      AL078582, BC128573, BE084831, DB285906
      Consensus CDS
      CCDS5234.1
      UniProtKB/Swiss-Prot
      P03372
      UniProtKB/TrEMBL
      G4XH65
      Related
      ENSP00000342630.5, OTTHUMP00000017719, ENST00000338799.9, OTTHUMT00000043309
      Conserved Domains (4) summary
      cd06949
      Location:310547
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:180261
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42181
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:556595
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    4. NM_001122742.1NP_001116214.1  estrogen receptor isoform 1

      See identical proteins and their annotated locations for NP_001116214.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses a different promoter, compared to variant 1. Variants 1-4 all encode the same isoform 1.
      Source sequence(s)
      AL078582, BC128573, BE084831, DA329077
      Consensus CDS
      CCDS5234.1
      UniProtKB/Swiss-Prot
      P03372
      UniProtKB/TrEMBL
      G4XH65
      Related
      ENSP00000405330.1, ENST00000440973.5
      Conserved Domains (4) summary
      cd06949
      Location:310547
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:180261
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42181
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:556595
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    5. NM_001291230.1NP_001278159.1  estrogen receptor isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and has an alternate splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) has additional two amino acids in the N-terminal region, compared to isoform 1.
      Source sequence(s)
      AK313644, AL078582, BC128573, DB285906
      UniProtKB/Swiss-Prot
      P03372
      Conserved Domains (4) summary
      cd06949
      Location:312549
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:180263
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42181
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:558597
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    6. NM_001291241.1NP_001278170.1  estrogen receptor isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and has an alternate splice site in the 5' coding region, compared to variant 1. The resulting isoform (3) lacks an internal aa in the N-terminal region, compared to isoform 1.
      Source sequence(s)
      AK293019, AL078582, BC128573, DB285906
      UniProtKB/Swiss-Prot
      P03372
      UniProtKB/TrEMBL
      A8KAF4
      Conserved Domains (4) summary
      cd06949
      Location:309546
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:180260
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42181
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:555594
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    7. NM_001328100.1NP_001315029.1  estrogen receptor isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the both UTRs, has a shorter 5' coding region and differs in the 3' coding region compared to variant 1. The encoded isoform (4) is shorter at the n-terminus and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL078582, BX640939
      UniProtKB/Swiss-Prot
      P03372
      UniProtKB/TrEMBL
      H0Y4W6

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

      Range
      151654148..152103274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010377.1XP_016865866.1  estrogen receptor isoform X1

      UniProtKB/Swiss-Prot
      P03372
      UniProtKB/TrEMBL
      G4XH65
      Conserved Domains (4) summary
      cd06949
      Location:310547
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:180261
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42181
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:556595
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    2. XM_017010376.1XP_016865865.1  estrogen receptor isoform X1

      UniProtKB/Swiss-Prot
      P03372
      UniProtKB/TrEMBL
      G4XH65
      Conserved Domains (4) summary
      cd06949
      Location:310547
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:180261
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42181
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:556595
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    3. XM_017010380.1XP_016865869.1  estrogen receptor isoform X1

      UniProtKB/Swiss-Prot
      P03372
      UniProtKB/TrEMBL
      G4XH65
      Conserved Domains (4) summary
      cd06949
      Location:310547
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:180261
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42181
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:556595
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    4. XM_011535543.2XP_011533845.1  estrogen receptor isoform X1

      See identical proteins and their annotated locations for XP_011533845.1

      UniProtKB/Swiss-Prot
      P03372
      UniProtKB/TrEMBL
      G4XH65
      Conserved Domains (4) summary
      cd06949
      Location:310547
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:180261
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42181
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:556595
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    5. XM_006715374.3XP_006715437.1  estrogen receptor isoform X3

      Conserved Domains (3) summary
      cd07171
      Location:180261
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42181
      Oest_recep; Oestrogen receptor
      cl11397
      Location:310456
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    6. XM_011535547.2XP_011533849.1  estrogen receptor isoform X2

      UniProtKB/TrEMBL
      A0A125SXW3
      Conserved Domains (3) summary
      cd07171
      Location:180261
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42181
      Oest_recep; Oestrogen receptor
      cl11397
      Location:310461
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    7. XM_017010378.1XP_016865867.1  estrogen receptor isoform X1

      UniProtKB/Swiss-Prot
      P03372
      UniProtKB/TrEMBL
      G4XH65
      Conserved Domains (4) summary
      cd06949
      Location:310547
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:180261
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42181
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:556595
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    8. XM_017010379.1XP_016865868.1  estrogen receptor isoform X1

      UniProtKB/Swiss-Prot
      P03372
      UniProtKB/TrEMBL
      G4XH65
      Conserved Domains (4) summary
      cd06949
      Location:310547
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:180261
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42181
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:556595
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    9. XM_011535545.2XP_011533847.1  estrogen receptor isoform X1

      See identical proteins and their annotated locations for XP_011533847.1

      UniProtKB/Swiss-Prot
      P03372
      UniProtKB/TrEMBL
      G4XH65
      Conserved Domains (4) summary
      cd06949
      Location:310547
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:180261
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42181
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:556595
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    10. XM_017010381.1XP_016865870.1  estrogen receptor isoform X1

      UniProtKB/Swiss-Prot
      P03372
      UniProtKB/TrEMBL
      G4XH65
      Conserved Domains (4) summary
      cd06949
      Location:310547
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:180261
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42181
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:556595
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    11. XM_011535544.2XP_011533846.1  estrogen receptor isoform X1

      See identical proteins and their annotated locations for XP_011533846.1

      UniProtKB/Swiss-Prot
      P03372
      UniProtKB/TrEMBL
      G4XH65
      Conserved Domains (4) summary
      cd06949
      Location:310547
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:180261
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42181
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:556595
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    12. XM_017010382.1XP_016865871.1  estrogen receptor isoform X5

    13. XM_006715375.3XP_006715438.1  estrogen receptor isoform X4

      See identical proteins and their annotated locations for XP_006715438.1

      UniProtKB/Swiss-Prot
      P03372
      Conserved Domains (3) summary
      cd06949
      Location:137374
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:788
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam12743
      Location:383422
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    14. XM_011535549.2XP_011533851.1  estrogen receptor isoform X6

      Conserved Domains (2) summary
      cd06949
      Location:67304
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      pfam12743
      Location:313352
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    15. XM_017010383.1XP_016865872.1  estrogen receptor isoform X7

    RNA

    1. XR_001743222.1 RNA Sequence

    2. XR_001743223.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      152275698..152688511
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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