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    TACR1 tachykinin receptor 1 [ Homo sapiens (human) ]

    Gene ID: 6869, updated on 11-Jun-2017
    Official Symbol
    TACR1provided by HGNC
    Official Full Name
    tachykinin receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:11526
    See related
    Ensembl:ENSG00000115353 MIM:162323; Vega:OTTHUMG00000129973
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPR; NK1R; NKIR; TAC1R
    Summary
    This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]
    Orthologs
    Location:
    2p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (75046463..75199519, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (75273590..75426645, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374809 Neighboring gene long intergenic non-protein coding RNA 1293 Neighboring gene DNA polymerase epsilon 4, accessory subunit Neighboring gene microRNA 5000 Neighboring gene uncharacterized LOC105374811 Neighboring gene uncharacterized LOC105374812 Neighboring gene uncharacterized LOC107985900 Neighboring gene uncharacterized LOC105374810

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity.
    NHGRI GWA Catalog
    Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
    NHGRI GWA Catalog
    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
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    • Calcium signaling pathway, conserved biosystem (from KEGG)
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    • Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
      Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystemRecruitment of plasma membrane-localized cargo into clathrin-coated endocytic vesicles is mediated by interaction with a variety of clathrin-interacting proteins collectively called CLASPs (clathrin-...
    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • Clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
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    • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
      Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
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    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Peptide GPCRs, organism-specific biosystem (from WikiPathways)
      Peptide GPCRs, organism-specific biosystem
      Peptide GPCRs
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    • Signal Transduction, organism-specific biosystem (from REACTOME)
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    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
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    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
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    • Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
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    • Tachykinin receptors bind tachykinins, organism-specific biosystem (from REACTOME)
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    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    substance P receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    tachykinin receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    acute inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    aggressive behavior IEA
    Inferred from Electronic Annotation
    more info
     
    angiotensin-mediated drinking behavior IEA
    Inferred from Electronic Annotation
    more info
     
    associative learning IEA
    Inferred from Electronic Annotation
    more info
     
    behavioral response to pain IEA
    Inferred from Electronic Annotation
    more info
     
    chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    detection of abiotic stimulus TAS
    Traceable Author Statement
    more info
    PubMed 
    eating behavior IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    long-term memory IEA
    Inferred from Electronic Annotation
    more info
     
    operant conditioning IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipase C-activating G-protein coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of action potential IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of epithelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of leukocyte migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of lymphocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ossification IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of renal sodium excretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of saliva secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of smooth muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of stress fiber assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of synaptic transmission, GABAergic IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of synaptic transmission, cholinergic IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of uterine smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of vascular permeability IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    response to auditory stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    response to electrical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    response to heat IEA
    Inferred from Electronic Annotation
    more info
     
    response to morphine IEA
    Inferred from Electronic Annotation
    more info
     
    response to nicotine IEA
    Inferred from Electronic Annotation
    more info
     
    response to ozone IEA
    Inferred from Electronic Annotation
    more info
     
    response to progesterone IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    smooth muscle contraction involved in micturition IEA
    Inferred from Electronic Annotation
    more info
     
    sperm ejaculation IEA
    Inferred from Electronic Annotation
    more info
     
    tachykinin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cell body IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    substance-P receptor
    Names
    NK-1 receptor
    NK-1R
    tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029522.1 RefSeqGene

      Range
      5001..158056
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001058.3NP_001049.1  substance-P receptor isoform long

      See identical proteins and their annotated locations for NP_001049.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (long) represents the longer and predominant transcript and it encodes the longer protein (isoform long).
      Source sequence(s)
      AC007400, AW206679, DB203452, M74290
      Consensus CDS
      CCDS1958.1
      UniProtKB/Swiss-Prot
      P25103
      Related
      ENSP00000303522.4, OTTHUMP00000160434, ENST00000305249.9, OTTHUMT00000252239
      Conserved Domains (1) summary
      pfam00001
      Location:54305
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. NM_015727.2NP_056542.1  substance-P receptor isoform short

      See identical proteins and their annotated locations for NP_056542.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (short) uses a different splice site in the 3' coding region, compared to variant long. The resulting protein (isoform short) has a shorter and distinct C-terminus when compared to the long isoform.
      Source sequence(s)
      AC007400, DB203452, M74290, M84426
      Consensus CDS
      CCDS46345.1
      UniProtKB/Swiss-Prot
      P25103
      Related
      ENSP00000386448.3, OTTHUMP00000202743, ENST00000409848.3, OTTHUMT00000328659
      Conserved Domains (1) summary
      pfam00001
      Location:54305
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      75046463..75199519 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      75202888..75356007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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