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    Igf2 insulin-like growth factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 16002, updated on 3-Dec-2017
    Official Symbol
    Igf2provided by MGI
    Official Full Name
    insulin-like growth factor 2provided by MGI
    Primary source
    MGI:MGI:96434
    See related
    Ensembl:ENSMUSG00000048583 Vega:OTTMUSG00000035324
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mpr; M6pr; Peg2; Igf-2; Igf-II; AL033362
    Summary
    This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. It is an imprinted gene that is expressed only from the paternal allele. The encoded protein undergoes proteolytic processing to generate a mature peptide. The transgenic overexpression of this gene in mice results in prenatal overgrowth, polyhydramnios, fetal and neonatal lethality, disproportionate organ overgrowth including tongue enlargement, and skeletal abnormalities. Mice lacking the encoded protein exhibit growth deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]
    Expression
    Biased expression in limb E14.5 (RPKM 601.7), liver E18 (RPKM 468.8) and 7 other tissues See more
    Orthologs
    Location:
    7 F5; 7 87.99 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (142650768..142666816, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (149836673..149846940, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene microRNA 675 Neighboring gene H19, imprinted maternally expressed transcript Neighboring gene predicted gene, 33148 Neighboring gene microRNA 483 Neighboring gene insulin-like growth factor 2, opposite strand Neighboring gene predicted gene, 46005 Neighboring gene insulin II

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    insulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    insulin-like growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    insulin-like growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    receptor ligand activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic placenta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    exocrine pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin receptor signaling pathway via phosphatidylinositol 3-kinase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    memory ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ossification IEA
    Inferred from Electronic Annotation
    more info
     
    osteoblast differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of activated T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of catalytic activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of glycogen (starch) synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of glycogen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of steroid hormone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of histone modification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    striated muscle cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    insulin-like growth factor II
    Names
    multiplication-stimulating polypeptide

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122736.2NP_001116208.1  insulin-like growth factor II isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001116208.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate exon at its 5' terminus and uses a downstream in-frame start codon, compared to variant 1. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein.
      Source sequence(s)
      AC013548, BC058615, CN527329
      Consensus CDS
      CCDS52458.1
      UniProtKB/Swiss-Prot
      P09535
      Related
      ENSMUSP00000101556.1, OTTMUSP00000015967, ENSMUST00000105936.7, OTTMUST00000035619
      Conserved Domains (2) summary
      cd04368
      Location:2891
      IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
      pfam08365
      Location:112166
      IGF2_C; Insulin-like growth factor II E-peptide
    2. NM_001122737.2NP_001116209.1  insulin-like growth factor II isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001116209.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate exon at its 5' terminus and uses a downstream in-frame start codon, compared to variant 1. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 encode the same protein.
      Source sequence(s)
      AC013548, BC058615
      Consensus CDS
      CCDS52458.1
      UniProtKB/Swiss-Prot
      P09535
      Related
      ENSMUSP00000000033.5, OTTMUSP00000015965, ENSMUST00000000033.11, OTTMUST00000035617
      Conserved Domains (2) summary
      cd04368
      Location:2891
      IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
      pfam08365
      Location:112166
      IGF2_C; Insulin-like growth factor II E-peptide
    3. NM_001315488.1NP_001302417.1  insulin-like growth factor II isoform 2 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate exon at its 5' terminus and uses a downstream in-frame start codon, compared to variant 1. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 encode the same protein.
      Source sequence(s)
      AC013548, CN666734
      Consensus CDS
      CCDS52458.1
      UniProtKB/Swiss-Prot
      P09535
      Related
      ENSMUSP00000101555.1, OTTMUSP00000015968, ENSMUST00000105935.7, OTTMUST00000035620
      Conserved Domains (2) summary
      cd04368
      Location:2891
      IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
      pfam08365
      Location:112166
      IGF2_C; Insulin-like growth factor II E-peptide
    4. NM_001315489.1NP_001302418.1  insulin-like growth factor II isoform 2 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate exon at its 5' terminus, lacks a portion of the 3' UTR and uses a downstream in-frame start codon, compared to variant 1. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 encode the same protein.
      Source sequence(s)
      AC013548, BC053489
      Consensus CDS
      CCDS52458.1
      UniProtKB/Swiss-Prot
      P09535
      Related
      ENSMUSP00000095549.2, ENSMUST00000097936.8
      Conserved Domains (2) summary
      cd04368
      Location:2891
      IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
      pfam08365
      Location:112166
      IGF2_C; Insulin-like growth factor II E-peptide
    5. NM_010514.3NP_034644.2  insulin-like growth factor II isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). This isoform (1) may undergo proteolytic processing similar to isoform 2.
      Source sequence(s)
      AC013548, CF742200
      Consensus CDS
      CCDS22033.2
      UniProtKB/Swiss-Prot
      P09535
      Related
      ENSMUSP00000114076.1, OTTMUSP00000015966, ENSMUST00000121128.7, OTTMUST00000035618
      Conserved Domains (2) summary
      cd04368
      Location:39102
      IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
      pfam08365
      Location:123177
      IGF2_C; Insulin-like growth factor II E-peptide

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      142650768..142666816 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508487.1XP_006508550.1  insulin-like growth factor II isoform X1

      See identical proteins and their annotated locations for XP_006508550.1

      UniProtKB/Swiss-Prot
      P09535
      Conserved Domains (2) summary
      cd04368
      Location:2891
      IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
      pfam08365
      Location:112166
      IGF2_C; Insulin-like growth factor II E-peptide
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