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    Prdm1 PR domain containing 1, with ZNF domain [ Mus musculus (house mouse) ]

    Gene ID: 12142, updated on 3-Jan-2017
    Official Symbol
    Prdm1provided by MGI
    Official Full Name
    PR domain containing 1, with ZNF domainprovided by MGI
    Primary source
    MGI:MGI:99655
    See related
    Ensembl:ENSMUSG00000038151 Vega:OTTMUSG00000035215
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Blimp1; Blimp-1; PRDI-BF1; ZNFPR1A1; b2b1765Clo
    Orthologs
    Location:
    10 B2; 10 23.24 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (44437174..44528560, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (44156981..44178493, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene autophagy related 5 Neighboring gene microRNA 1929 Neighboring gene predicted gene, 35028 Neighboring gene triosephosphate isomerase 1 pseudogene Neighboring gene predicted gene, 35154

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (15)  1 citation
    • Chemically induced (ENU) (1) 
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    aorta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    artery morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    artery morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular developmental process IEA
    Inferred from Electronic Annotation
    more info
     
    coronary vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    eye photoreceptor cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    germ cell development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    heart valve development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    intestinal epithelial cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maternal placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    methylation IEA
    Inferred from Electronic Annotation
    more info
     
    morphogenesis of a branching structure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of B cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of lipopolysaccharide-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of B cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT positive regulation of B cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of NK T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of extrathymic T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of natural killer cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    sebum secreting cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    trophoblast giant cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ventricular septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    PR domain zinc finger protein 1
    Names
    B lymphocyte induced maturation protein
    B lymphocyte-induced maturation protein 1
    PR domain-containing protein 1
    beta-interferon gene positive regulatory domain I-binding factor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007548.4NP_031574.2  PR domain zinc finger protein 1

      See identical proteins and their annotated locations for NP_031574.2

      Status: VALIDATED

      Source sequence(s)
      AC027700, AK133503, AK149344, BE954935
      Consensus CDS
      CCDS23825.2
      UniProtKB/Swiss-Prot
      Q60636
      Related
      ENSMUSP00000101129, OTTMUSP00000049055, ENSMUST00000105490, OTTMUST00000089715
      Conserved Domains (5) summary
      smart00317
      Location:99205
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG5048
      Location:419686
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:575595
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:573595
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:615640
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      44437174..44528560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512503.2XP_006512566.1  

      See identical proteins and their annotated locations for XP_006512566.1

      UniProtKB/Swiss-Prot
      Q60636
      Conserved Domains (5) summary
      smart00317
      Location:65171
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG5048
      Location:385652
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:541561
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:539561
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:581606
      zf-H2C2_2; Zinc-finger double domain
    2. XM_011243109.1XP_011241411.1  

      See identical proteins and their annotated locations for XP_011241411.1

      UniProtKB/Swiss-Prot
      Q60636
      Conserved Domains (5) summary
      smart00317
      Location:65171
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG5048
      Location:385652
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:541561
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:539561
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:581606
      zf-H2C2_2; Zinc-finger double domain
    3. XM_006512505.2XP_006512568.1  

      See identical proteins and their annotated locations for XP_006512568.1

      UniProtKB/Swiss-Prot
      Q60636
      Related
      ENSMUSP00000039248, OTTMUSP00000049054, ENSMUST00000039174, OTTMUST00000089714
      Conserved Domains (5) summary
      smart00317
      Location:132238
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG5048
      Location:452719
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:608628
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:606628
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:648673
      zf-H2C2_2; Zinc-finger double domain
    4. XM_006512502.3XP_006512565.1  

      UniProtKB/Swiss-Prot
      Q60636
      Conserved Domains (5) summary
      smart00317
      Location:114220
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG5048
      Location:434701
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:590610
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:588610
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:630655
      zf-H2C2_2; Zinc-finger double domain
    5. XM_006512504.3XP_006512567.1  

      Conserved Domains (5) summary
      smart00317
      Location:148
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG5048
      Location:247529
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:418438
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:416438
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:458483
      zf-H2C2_2; Zinc-finger double domain
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