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    Casp2 caspase 2 [ Mus musculus (house mouse) ]

    Gene ID: 12366, updated on 4-Jun-2017
    Official Symbol
    Casp2provided by MGI
    Official Full Name
    caspase 2provided by MGI
    Primary source
    MGI:MGI:97295
    See related
    Ensembl:ENSMUSG00000029863 Vega:OTTMUSG00000023653
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ICH-1; Nedd2; CASP-2; NEDD-2
    Summary
    This gene encodes the evolutionarily ancient and most conserved member of the cysteine proteases that plays important role in stress-induced apoptosis, DNA repair and tumor suppression. Mice lacking the encoded protein develop normally but display cell type-specific apoptotic defects. Germ cells and oocytes from such mice were found to be resistant to cell death after treatment with chemotherapeutic drugs. [provided by RefSeq, Apr 2015]
    Orthologs
    Location:
    6 B2.1; 6 20.54 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (42264898..42282508)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (42215038..42232495)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase kappa 1 Neighboring gene transmembrane protein 139 Neighboring gene chloride channel, voltage-sensitive 1 Neighboring gene predicted gene, 38797 Neighboring gene family with sequence similarity 131, member B

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase activity RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ectopic germ cell programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    execution phase of apoptosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    extrinsic apoptotic signaling pathway in absence of ligand IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    caspase-2
    Names
    neural precursor cell expressed developmentally down-regulated protein 2
    protease ICH-1
    NP_031636.1
    XP_006505516.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007610.2NP_031636.1  caspase-2 precursor

      See identical proteins and their annotated locations for NP_031636.1

      Status: REVIEWED

      Source sequence(s)
      AC153915, AK042072, AW046437, BY074786
      Consensus CDS
      CCDS20064.1
      UniProtKB/Swiss-Prot
      P29594
      Related
      ENSMUSP00000031895.6, OTTMUSP00000027875, ENSMUST00000031895.12, OTTMUST00000057721
      Conserved Domains (2) summary
      smart00115
      Location:192447
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08332
      Location:32118
      CARD_CASP2; Caspase activation and recruitment domain of Caspase-2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      42264898..42282508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505453.2XP_006505516.1  caspase-2 isoform X1

      Conserved Domains (1) summary
      cl14633
      Location:32118
      DD; Death Domain Superfamily of protein-protein interaction domains

    RNA

    1. XR_377417.2 RNA Sequence

    2. XR_377418.3 RNA Sequence

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