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    Sirt6 sirtuin 6 [ Mus musculus (house mouse) ]

    Gene ID: 50721, updated on 7-May-2017
    Official Symbol
    Sirt6provided by MGI
    Official Full Name
    sirtuin 6provided by MGI
    Primary source
    MGI:MGI:1354161
    See related
    Ensembl:ENSMUSG00000034748 Vega:OTTMUSG00000030471
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sir2l6; AI043036; 2810449N18Rik
    Orthologs
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (81621786..81627797, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (81084531..81090353, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32024 Neighboring gene transducin-like enhancer of split 6 Neighboring gene zinc finger protein pseudogene Neighboring gene ankyrin repeat domain 24 Neighboring gene predicted gene 10778 Neighboring gene 60S ribosomal protein L23a pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NAD(P)+-protein-arginine ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
     
    NAD-dependent histone deacetylase activity (H3-K9 specific) IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NAD-dependent histone deacetylase activity (H3-K9 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription corepressor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    base-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of glucose import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation blood vessel branching ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chondrocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chromatin silencing at telomere ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomeric heterochromatin assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vascular endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    post-embryonic cardiac muscle cell growth involved in heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    protein ADP-ribosylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein destabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear telomeric heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    NAD-dependent protein deacetylase sirtuin-6
    Names
    NAD-dependent deacetylase sirtuin-6
    SIR2-like protein 6
    regulatory protein SIR2 homolog 6
    NP_001156902.1
    NP_853617.1
    XP_006513924.1
    XP_006513926.1
    XP_011241809.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163430.1NP_001156902.1  NAD-dependent protein deacetylase sirtuin-6 isoform 2

      See identical proteins and their annotated locations for NP_001156902.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the UTRs and 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC153919, AK145929, BY606083, CJ302020
      Consensus CDS
      CCDS48645.1
      UniProtKB/TrEMBL
      Q3UKP1
      Related
      ENSMUSP00000113953.1, OTTMUSP00000039549, ENSMUST00000119324.7, OTTMUST00000075441
      Conserved Domains (1) summary
      cd01410
      Location:5217
      SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...
    2. NM_181586.3NP_853617.1  NAD-dependent protein deacetylase sirtuin-6 isoform 1

      See identical proteins and their annotated locations for NP_853617.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC153919, AK013316, BC052763, BY606083
      Consensus CDS
      CCDS24066.1
      UniProtKB/Swiss-Prot
      P59941
      Related
      ENSMUSP00000048971.8, OTTMUSP00000039548, ENSMUST00000042923.8, OTTMUST00000075440
      Conserved Domains (1) summary
      cd01410
      Location:45257
      SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      81621786..81627797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513861.3XP_006513924.1  NAD-dependent protein deacetylase sirtuin-6 isoform X1

      Conserved Domains (1) summary
      cd01410
      Location:101313
      SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...
    2. XM_006513863.3XP_006513926.1  NAD-dependent protein deacetylase sirtuin-6 isoform X3

      Conserved Domains (1) summary
      cl00195
      Location:1185
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
    3. XM_011243507.2XP_011241809.1  NAD-dependent protein deacetylase sirtuin-6 isoform X2

      Conserved Domains (1) summary
      cl00195
      Location:101261
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
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