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    DAM1 Dam1p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 853010, updated on 5-Mar-2017
    Gene symbol
    DAM1
    Gene description
    Dam1p
    Primary source
    SGD:S000003345
    Locus tag
    YGR113W
    Gene type
    protein coding
    RNA name
    Dam1p
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    See DAM1 in Map Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (718893..719924)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene Shy1p Neighboring gene chromatin-remodeling histone chaperone SPT6 Neighboring gene hypothetical protein

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Cell Cycle and Cell Division, organism-specific biosystem (from WikiPathways)
      Cell Cycle and Cell Division, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle - yeast, organism-specific biosystem (from KEGG)
      Cell cycle - yeast, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps (G1 and G2 phases). G1, S, and G...
    • Cell cycle - yeast, conserved biosystem (from KEGG)
      Cell cycle - yeast, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps (G1 and G2 phases). G1, S, and G...
    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    contributes_to microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    attachment of spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    attachment of spindle microtubules to kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic sister chromatid biorientation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of attachment of spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of microtubule polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    DASH complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DASH complex IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    condensed chromosome kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic spindle polar microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mitotic spindle pole body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    spindle IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    Dam1p
    NP_011628.4
    • Essential subunit of the Dam1 complex (aka DASH complex); cooperates with Duo1p to connect the DASH complex with the microtubules (MT); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      718893..719924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181242.3NP_011628.4  TPA: Dam1p [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_011628.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P53267
      Conserved Domains (1) summary
      pfam08653
      Location:63118
      DASH_Dam1; DASH complex subunit Dam1
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