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    HOXA5 homeobox A5 [ Homo sapiens (human) ]

    Gene ID: 3202, updated on 9-Apr-2017
    Official Symbol
    HOXA5provided by HGNC
    Official Full Name
    homeobox A5provided by HGNC
    Primary source
    HGNC:HGNC:5106
    See related
    Ensembl:ENSG00000106004 MIM:142952; Vega:OTTHUMG00000023214
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HOX1; HOX1C; HOX1.3
    Summary
    In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    7p15.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 7 NC_000007.14 (27141052..27143668, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (27180671..27192309, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene homeobox A2 Neighboring gene homeobox A3 Neighboring gene HOXA cluster antisense RNA 2 Neighboring gene homeobox A4 Neighboring gene HOXA cluster antisense RNA 3 Neighboring gene homeobox A6 Neighboring gene homeobox A7

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC9376

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    bronchiole development IEA
    Inferred from Electronic Annotation
    more info
     
    cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell signaling involved in mammary gland development IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic skeletal system morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial tube branching involved in lung morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    intestinal epithelial cell maturation IEA
    Inferred from Electronic Annotation
    more info
     
    lung alveolus development IEA
    Inferred from Electronic Annotation
    more info
     
    lung goblet cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    lung-associated mesenchyme development IEA
    Inferred from Electronic Annotation
    more info
     
    mammary gland alveolus development IEA
    Inferred from Electronic Annotation
    more info
     
    mammary gland epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    mesenchymal-epithelial cell signaling IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of erythrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of myeloid cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of receptor biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of mammary gland epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    respiratory system process IEA
    Inferred from Electronic Annotation
    more info
     
    thyroid gland development IEA
    Inferred from Electronic Annotation
    more info
     
    trachea cartilage morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    homeobox protein Hox-A5
    Names
    homeo box 1C
    homeo box A5
    homeobox protein HOXA5
    homeobox protein Hox-1C

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019102.3NP_061975.2  homeobox protein Hox-A5

      See identical proteins and their annotated locations for NP_061975.2

      Status: REVIEWED

      Source sequence(s)
      AC004080, BC013682, BI822268
      Consensus CDS
      CCDS5406.1
      UniProtKB/Swiss-Prot
      P20719
      Related
      ENSP00000222726.3, OTTHUMP00000217259, ENST00000222726.3, OTTHUMT00000358705
      Conserved Domains (1) summary
      pfam00046
      Location:199251
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p7 Primary Assembly

      Range
      27141052..27143668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018918.2 Alternate CHM1_1.1

      Range
      27180379..27182993 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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