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    CDC34 SCF E2 ubiquitin-protein ligase catalytic subunit CDC34 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 851624, updated on 5-Feb-2017
    Gene symbol
    CDC34
    Gene description
    SCF E2 ubiquitin-protein ligase catalytic subunit CDC34
    Primary source
    SGD:S000002461
    Locus tag
    YDR054C
    Gene type
    protein coding
    RNA name
    SCF E2 ubiquitin-protein ligase catalytic subunit CDC34
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DNA6; UBC3
    See CDC34 in Map Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (561440..562327, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene acid phosphatase DET1 Neighboring gene protein serine/threonine kinase activating protein DBF4 Neighboring gene Pst1p Neighboring gene Emc10p

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Cell Cycle and Cell Division, organism-specific biosystem (from WikiPathways)
      Cell Cycle and Cell Division, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-protein transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    G2/M transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autoubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SCF ubiquitin ligase complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    SCF ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    SCF E2 ubiquitin-protein ligase catalytic subunit CDC34
    NP_010339.1
    • Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress; human CDC34 functionally complements the thermosensitivity of the cdc34-2 mutant

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      561440..562327 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180362.1NP_010339.1  TPA: SCF E2 ubiquitin-protein ligase catalytic subunit CDC34 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_010339.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P14682
      Conserved Domains (2) summary
      COG5078
      Location:3170
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00179
      Location:14164
      UQ_con; Ubiquitin-conjugating enzyme
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