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    Ntrk2 neurotrophic receptor tyrosine kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25054, updated on 26-Nov-2017
    Official Symbol
    Ntrk2provided by RGD
    Official Full Name
    neurotrophic receptor tyrosine kinase 2provided by RGD
    Primary source
    RGD:3213
    See related
    Ensembl:ENSRNOG00000018839
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tkrb; trkB; TRKB1; trk-B; RATTRKB1
    Summary
    receptor for brain-derived neurotrophic factor (BDNF) [RGD, Feb 2006]
    Expression
    Biased expression in Brain (RPKM 177.9), Spleen (RPKM 47.3) and 6 other tissues See more
    Orthologs
    Location:
    17p14
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (5934651..6245778, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (8156432..8464522, complement)

    Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene ATP/GTP binding protein 1 Neighboring gene uncharacterized LOC108348495 Neighboring gene uncharacterized LOC102548918 Neighboring gene uncharacterized LOC108353117 Neighboring gene uncharacterized LOC102556161 Neighboring gene solute carrier family 28 member 3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    brain-derived neurotrophic factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    brain-derived neurotrophic factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    brain-derived neurotrophic factor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    brain-derived neurotrophic factor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    brain-derived neurotrophic factor-activated receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    brain-derived neurotrophic factor-activated receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    brain-derived neurotrophic factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neurotrophin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neurotrophin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neurotrophin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neurotrophin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neurotrophin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transmembrane receptor protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    transmembrane receptor protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    Ras protein signal transduction TAS
    Traceable Author Statement
    more info
     
    activation of MAPKK activity TAS
    Traceable Author Statement
    more info
     
    activation of adenylate cyclase activity TAS
    Traceable Author Statement
    more info
     
    activation of phospholipase C activity TAS
    Traceable Author Statement
    more info
     
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    brain-derived neurotrophic factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    brain-derived neurotrophic factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    brain-derived neurotrophic factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    brain-derived neurotrophic factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    calcium-mediated signaling using intracellular calcium source ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to amino acid stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to brain-derived neurotrophic factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to nerve growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to tumor necrosis factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    central nervous system neuron development IEA
    Inferred from Electronic Annotation
    more info
     
    central nervous system neuron development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    central nervous system neuron development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cerebral cortex development IEA
    Inferred from Electronic Annotation
    more info
     
    cerebral cortex development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cerebral cortex development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    circadian rhythm IEA
    Inferred from Electronic Annotation
    more info
     
    circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    feeding behavior IEA
    Inferred from Electronic Annotation
    more info
     
    feeding behavior ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    glutamate secretion IEA
    Inferred from Electronic Annotation
    more info
     
    glutamate secretion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    inflammatory response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    learning IEA
    Inferred from Electronic Annotation
    more info
     
    learning ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    learning ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    long-term memory IDA
    Inferred from Direct Assay
    more info
    PubMed 
    long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
     
    long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mechanoreceptor differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    mechanoreceptor differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of anoikis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuromuscular junction development IEA
    Inferred from Electronic Annotation
    more info
     
    neuromuscular junction development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    neuron migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neurotrophin TRK receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    neurotrophin signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    oligodendrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    oligodendrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    peripheral nervous system neuron development IEA
    Inferred from Electronic Annotation
    more info
     
    peripheral nervous system neuron development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of glucocorticoid receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of synapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of neurotransmitter secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein kinase B signaling IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to auditory stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    retina development in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    retina development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    retinal rod cell development IEA
    Inferred from Electronic Annotation
    more info
     
    retinal rod cell development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    trans-synaptic signaling by neuropeptide, modulating synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    trans-synaptic signaling by neuropeptide, modulating synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transmembrane receptor protein serine/threonine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi membrane TAS
    Traceable Author Statement
    more info
     
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    early endosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    endosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    excitatory synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    rough endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    terminal bouton IEA
    Inferred from Electronic Annotation
    more info
     
    terminal bouton ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    BDNF/NT-3 growth factors receptor
    Names
    GP145-TrkB/GP95-TrkB
    neural receptor protein-tyrosine kinase (trkB)
    neurotrophic tyrosine kinase, receptor, type 2
    neurotrophic tyrosine receptor kinase type 2
    trkB tyrosine kinase
    NP_001156640.1
    NP_036863.1
    XP_006253569.1
    XP_008769647.1
    XP_008769648.1
    XP_008769649.1
    XP_017455945.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163168.2NP_001156640.1  BDNF/NT-3 growth factors receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_001156640.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple coding exons and uses a distinct terminal exon compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to to isoform 1.
      Source sequence(s)
      AABR07026940, AABR07026943, AABR07026944
      UniProtKB/Swiss-Prot
      Q63604
      Related
      ENSRNOP00000070128.1, ENSRNOT00000090914.1
      Conserved Domains (7) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      smart00013
      Location:3164
      LRRNT; Leucine rich repeat N-terminal domain
      smart00410
      Location:204283
      IG_like; Immunoglobulin like
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      cl11960
      Location:204283
      Ig; Immunoglobulin domain
      cl15307
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    2. NM_012731.2NP_036863.1  BDNF/NT-3 growth factors receptor isoform 1 precursor

      See identical proteins and their annotated locations for NP_036863.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AABR07026938, AABR07026943, AABR07026944
      UniProtKB/Swiss-Prot
      Q63604
      Related
      ENSRNOP00000045635.1, ENSRNOT00000042145.2
      Conserved Domains (7) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      smart00410
      Location:204283
      IG_like; Immunoglobulin like
      cd05093
      Location:531818
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam07714
      Location:537806
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      cl11960
      Location:204283
      Ig; Immunoglobulin domain
      cl15307
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

      Range
      5934651..6245778 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600456.1XP_017455945.1  BDNF/NT-3 growth factors receptor isoform X1

      UniProtKB/TrEMBL
      A0A0G2K5X6
      Conserved Domains (7) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      smart00410
      Location:204283
      IG_like; Immunoglobulin like
      cd05093
      Location:547834
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam07714
      Location:553822
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      cl11960
      Location:204283
      Ig; Immunoglobulin domain
      cl15307
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    2. XM_008771426.2XP_008769648.1  BDNF/NT-3 growth factors receptor isoform X1

      See identical proteins and their annotated locations for XP_008769648.1

      UniProtKB/TrEMBL
      A0A0G2K5X6
      Conserved Domains (7) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      smart00410
      Location:204283
      IG_like; Immunoglobulin like
      cd05093
      Location:547834
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam07714
      Location:553822
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      cl11960
      Location:204283
      Ig; Immunoglobulin domain
      cl15307
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    3. XM_008771425.2XP_008769647.1  BDNF/NT-3 growth factors receptor isoform X1

      See identical proteins and their annotated locations for XP_008769647.1

      UniProtKB/TrEMBL
      A0A0G2K5X6
      Related
      ENSRNOP00000073595.1, ENSRNOT00000082611.1
      Conserved Domains (7) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      smart00410
      Location:204283
      IG_like; Immunoglobulin like
      cd05093
      Location:547834
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam07714
      Location:553822
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      cl11960
      Location:204283
      Ig; Immunoglobulin domain
      cl15307
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    4. XM_006253507.3XP_006253569.1  BDNF/NT-3 growth factors receptor isoform X2

      Conserved Domains (7) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      smart00013
      Location:3164
      LRRNT; Leucine rich repeat N-terminal domain
      smart00410
      Location:204283
      IG_like; Immunoglobulin like
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      cl11960
      Location:204283
      Ig; Immunoglobulin domain
      cl15307
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    5. XM_008771427.2XP_008769649.1  BDNF/NT-3 growth factors receptor isoform X3

      Conserved Domains (7) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      smart00013
      Location:3164
      LRRNT; Leucine rich repeat N-terminal domain
      smart00410
      Location:204283
      IG_like; Immunoglobulin like
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      cl11960
      Location:204283
      Ig; Immunoglobulin domain
      cl15307
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    Alternate Rn_Celera

    Genomic

    1. AC_000085.1 Alternate Rn_Celera

      Range
      5673895..6828108 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001163169.1: Suppressed sequence

      Description
      NM_001163169.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Support Center