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    Slpi secretory leukocyte peptidase inhibitor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84386, updated on 1-Jun-2017
    Official Symbol
    Slpiprovided by RGD
    Official Full Name
    secretory leukocyte peptidase inhibitorprovided by RGD
    Primary source
    RGD:621768
    See related
    Ensembl:ENSRNOG00000046699 Vega:OTTRNOG00000001237
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    suppresses the inflammation and joint damage caused by bacterial cell wall-induced arthritis [RGD, Feb 2006]
    Location:
    3q42
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (160799979..160802228, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (166981037..166983286, complement)

    Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene antileukoproteinase-like 2 Neighboring gene antileukoproteinase-like 3 Neighboring gene matrilin 4 Neighboring gene recombination signal binding protein for immunoglobulin kappa J region-like Neighboring gene syndecan 4

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    serine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    antibacterial humoral response ISO
    Inferred from Sequence Orthology
    more info
     
    immune response ISO
    Inferred from Sequence Orthology
    more info
     
    innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    modification of morphology or physiology of other organism ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular_component ND
    No biological Data available
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    secretory leukocyte peptidase inhibitor
    Names
    secretory leukocyte protease inhibitor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053372.1NP_445824.1  secretory leukocyte peptidase inhibitor precursor

      See identical proteins and their annotated locations for NP_445824.1

      Status: PROVISIONAL

      Source sequence(s)
      AF151982
      UniProtKB/TrEMBL
      Q9WUQ4
      Related
      ENSRNOP00000068012.1, OTTRNOP00000001100, ENSRNOT00000076191.1, OTTRNOT00000001902
      Conserved Domains (2) summary
      smart00217
      Location:85130
      WAP; Four-disulfide core domains
      pfam00095
      Location:3476
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

      Range
      160799979..160802228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000071.1 Alternate Rn_Celera

      Range
      151693623..151695872 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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