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    Hoxa10 homeobox A10 [ Mus musculus (house mouse) ]

    Gene ID: 15395, updated on 12-Mar-2017
    Official Symbol
    Hoxa10provided by MGI
    Official Full Name
    homeobox A10provided by MGI
    Primary source
    MGI:MGI:96171
    See related
    Ensembl:ENSMUSG00000000938 Vega:OTTMUSG00000018886
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hox-1.8; Hoxa-10
    Summary
    In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of a cluster on chromosome 6 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    6 B3; 6 25.4 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (52231197..52240854, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (52181196..52190853, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene homeobox A9 Neighboring gene microRNA 196b Neighboring gene homeobox A11 Neighboring gene homeobox A11, opposite strand Neighboring gene homeobox A13

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    anterior/posterior pattern specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic limb morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    male gonad development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    multicellular organism development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    proximal/distal pattern formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    single fertilization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    skeletal system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    uterus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    homeobox protein Hox-A10
    Names
    homeo box A10
    homeobox protein Hox-1.8

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122950.2NP_001116422.1  homeobox protein Hox-A10 isoform b

      See identical proteins and their annotated locations for NP_001116422.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1, resulting in a protein (isoform b) that is shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC015583, BC050839
      Consensus CDS
      CCDS51775.1
      UniProtKB/Swiss-Prot
      P31310
      Related
      ENSMUSP00000112872, OTTMUSP00000032364, ENSMUST00000121043, OTTMUST00000045423
      Conserved Domains (1) summary
      pfam00046
      Location:2376
      Homeobox; Homeobox domain
    2. NM_008263.3NP_032289.2  homeobox protein Hox-A10 isoform a

      See identical proteins and their annotated locations for NP_032289.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform a).
      Source sequence(s)
      AC015583, BC050839
      Consensus CDS
      CCDS20147.2
      UniProtKB/Swiss-Prot
      P31310
      Related
      ENSMUSP00000120276, OTTMUSP00000020429, ENSMUST00000125581, OTTMUST00000045420
      Conserved Domains (1) summary
      pfam00046
      Location:345398
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      52231197..52240854 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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