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    P2RX5 purinergic receptor P2X 5 [ Homo sapiens (human) ]

    Gene ID: 5026, updated on 22-Apr-2017
    Official Symbol
    P2RX5provided by HGNC
    Official Full Name
    purinergic receptor P2X 5provided by HGNC
    Primary source
    HGNC:HGNC:8536
    See related
    Ensembl:ENSG00000083454 MIM:602836; Vega:OTTHUMG00000090700
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P2X5; LRH-1; P2X5R
    Summary
    The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream gene, TAX1BP3 (Tax1 binding protein 3). [provided by RefSeq, Mar 2011]
    Orthologs
    Location:
    17p13.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (3673227..3696404, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (3575156..3599698, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene P2RX5-TAX1BP3 readthrough (NMD candidate) Neighboring gene ribosomal protein L21 pseudogene 125 Neighboring gene Tax1 binding protein 3 Neighboring gene ER membrane protein complex subunit 6 Neighboring gene integrin subunit alpha E Neighboring gene histone H3 associated protein kinase Neighboring gene nuclear cap binding subunit 3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of purinergic receptor P2X, ligand-gated ion channel, 5 (P2RX5) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication PubMed

    Go to the HIV-1, Human Interaction Database

    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Elevation of cytosolic Ca2+ levels, organism-specific biosystem (from REACTOME)
      Elevation of cytosolic Ca2+ levels, organism-specific biosystemActivation of non- excitable cells involves the agonist-induced elevation of cytosolic Ca2+, an essential process for platelet activation. It occurs through Ca2+ release from intracellular stores and...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Platelet calcium homeostasis, organism-specific biosystem (from REACTOME)
      Platelet calcium homeostasis, organism-specific biosystemCa2+ homeostasis is controlled by processes that elevate or counter the elevation of cytosolic Ca2+. During steady state conditions, cytoplasmic Ca2+ is reduced by the accumulation of Ca2+ in intrac...
    • Platelet homeostasis, organism-specific biosystem (from REACTOME)
      Platelet homeostasis, organism-specific biosystemUnder normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in charact...

    Markers

    Readthrough P2RX5-TAX1BP3

    Readthrough gene: P2RX5-TAX1BP3, Included gene: TAX1BP3

    Homology

    Clone Names

    • MGC47755

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular ATP-gated cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    extracellular ATP-gated cation channel activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    ion channel activity TAS
    Traceable Author Statement
    more info
    PubMed 
    purinergic nucleotide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    purinergic nucleotide receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    transmembrane signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    blood coagulation TAS
    Traceable Author Statement
    more info
     
    cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of calcium ion transport into cytosol NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of calcium-mediated signaling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    purinergic nucleotide receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    response to ATP IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    integral component of nuclear inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    P2X purinoceptor 5
    Names
    ATP receptor subunit
    ionotropic ATP receptor P2X5
    lymphoid-restricted histocompatibility antigen-1
    purinergic receptor P2X, ligand gated ion channel, 5

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204519.1NP_001191448.1  P2X purinoceptor 5 isoform D

      See identical proteins and their annotated locations for NP_001191448.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (D) that is shorter than isoform A.
      Source sequence(s)
      AK290889, BC028084
      Consensus CDS
      CCDS56015.1
      UniProtKB/Swiss-Prot
      Q93086
      Related
      ENSP00000448355.1, OTTHUMP00000241719, ENST00000547178.5, OTTHUMT00000405138
      Conserved Domains (1) summary
      TIGR00863
      Location:1350
      P2X; cation transporter protein
    2. NM_001204520.1NP_001191449.1  P2X purinoceptor 5 isoform E

      See identical proteins and their annotated locations for NP_001191449.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (E) that is shorter than isoform A.
      Source sequence(s)
      AA805176, AK290889, DQ234349
      Consensus CDS
      CCDS56014.1
      UniProtKB/Swiss-Prot
      Q93086
      Related
      ENSP00000342161.3, OTTHUMP00000241720, ENST00000345901.7, OTTHUMT00000405140
      Conserved Domains (1) summary
      TIGR00863
      Location:1327
      P2X; cation transporter protein
    3. NM_002561.3NP_002552.2  P2X purinoceptor 5 isoform A

      See identical proteins and their annotated locations for NP_002552.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (A).
      Source sequence(s)
      AA805176, AK290889
      Consensus CDS
      CCDS11034.1
      UniProtKB/Swiss-Prot
      Q93086
      Related
      ENSP00000225328.5, OTTHUMP00000115870, ENST00000225328.9, OTTHUMT00000207388
      Conserved Domains (1) summary
      TIGR00863
      Location:1351
      P2X; cation transporter protein
    4. NM_175080.2NP_778255.1  P2X purinoceptor 5 isoform B

      See identical proteins and their annotated locations for NP_778255.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (B) that is shorter than isoform A.
      Source sequence(s)
      AA805176, AF070573, AK290889
      Consensus CDS
      CCDS11035.1
      UniProtKB/Swiss-Prot
      Q93086
      Related
      ENSP00000447545.1, OTTHUMP00000241718, ENST00000551178.5, OTTHUMT00000405137
      Conserved Domains (1) summary
      TIGR00863
      Location:1326
      P2X; cation transporter protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      3673227..3696404 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      3587157..3608787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_175081.1: Suppressed sequence

      Description
      NM_175081.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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