Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    CPA3 carboxypeptidase A3 [ Homo sapiens (human) ]

    Gene ID: 1359, updated on 28-Sep-2017
    Official Symbol
    CPA3provided by HGNC
    Official Full Name
    carboxypeptidase A3provided by HGNC
    Primary source
    HGNC:HGNC:2298
    See related
    Ensembl:ENSG00000163751 MIM:114851; Vega:OTTHUMG00000159526
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MC-CPA
    Summary
    This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein is proteolytically processed to generate a mature protease that is released by mast cells and may be involved in the degradation of endogenous proteins and the inactivation of venom-associated peptides. Expression of this gene may be elevated in human asthma patients. [provided by RefSeq, Nov 2015]
    Expression
    Biased expression in gall bladder (RPKM 74.3), lung (RPKM 46.6) and 11 other tissues See more
    Orthologs
    Location:
    3q24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (148865256..148897091)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (148583043..148614874)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene high mobility group box 1 pseudogene 30 Neighboring gene carboxypeptidase B1 Neighboring gene uncharacterized LOC107986045 Neighboring gene ubiquilin 4 pseudogene 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystem (from REACTOME)
      Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystemAngiotensinogen, a prohormone, is synthesized and secreted mainly by the liver but also from other tissues (reviewed in Fyhrquist and Saijonmaa 2008, Cat and Touyz 2011). Renin, an aspartyl protease ...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Pancreatic secretion, organism-specific biosystem (from KEGG)
      Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
    • Pancreatic secretion, conserved biosystem (from KEGG)
      Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
    • Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
      Peptide hormone metabolism, organism-specific biosystemPeptide hormones are cleaved from larger precursors in the secretory system (endoplasmic reticulum, Golgi apparatus, secretory granules) of the cell. After secretion peptide hormones are modified and...
    • Protein digestion and absorption, organism-specific biosystem (from KEGG)
      Protein digestion and absorption, organism-specific biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
    • Protein digestion and absorption, conserved biosystem (from KEGG)
      Protein digestion and absorption, conserved biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
    • Renin-angiotensin system, organism-specific biosystem (from KEGG)
      Renin-angiotensin system, organism-specific biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
    • Renin-angiotensin system, conserved biosystem (from KEGG)
      Renin-angiotensin system, conserved biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metallocarboxypeptidase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    metallocarboxypeptidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    metallocarboxypeptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    angiotensin maturation TAS
    Traceable Author Statement
    more info
     
    proteolysis TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    secretory granule NAS
    Non-traceable Author Statement
    more info
    PubMed 
    transport vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    mast cell carboxypeptidase A
    Names
    carboxypeptidase A3 (mast cell)
    tissue carboxypeptidase A
    NP_001861.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001870.3NP_001861.2  mast cell carboxypeptidase A preproprotein

      See identical proteins and their annotated locations for NP_001861.2

      Status: REVIEWED

      Source sequence(s)
      BC012613, BG501260, BX105358, DR005288, M27717
      Consensus CDS
      CCDS3138.1
      UniProtKB/Swiss-Prot
      P15088
      Related
      ENSP00000296046.3, OTTHUMP00000215693, ENST00000296046.3, OTTHUMT00000355974
      Conserved Domains (2) summary
      cd03871
      Location:114413
      M14_CPB; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase B subgroup
      pfam02244
      Location:28102
      Propep_M14; Carboxypeptidase activation peptide

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

      Range
      148865256..148897091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      148545876..148577721
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center