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    P2RY14 purinergic receptor P2Y14 [ Homo sapiens (human) ]

    Gene ID: 9934, updated on 7-May-2017
    Official Symbol
    P2RY14provided by HGNC
    Official Full Name
    purinergic receptor P2Y14provided by HGNC
    Primary source
    HGNC:HGNC:16442
    See related
    Ensembl:ENSG00000174944 MIM:610116; Vega:OTTHUMG00000159859
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P2Y14; BPR105; GPR105
    Summary
    The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    3q25.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (151212115..151279165, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (150929905..150996996, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 12 like Neighboring gene RNA, 5S ribosomal pseudogene 145 Neighboring gene G protein-coupled receptor 171 Neighboring gene SET pseudogene 11 Neighboring gene G protein-coupled receptor 87 Neighboring gene purinergic receptor P2Y13

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of purinergic receptor P2Y, G-protein coupled, 14 (P2RY14) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Nucleotide-like (purinergic) receptors, organism-specific biosystem (from REACTOME)
      Nucleotide-like (purinergic) receptors, organism-specific biosystemPurinergic receptors (Burnstock G, 2006; Abbracchio MP et al, 2009) are a family of newly characterized plasma membrane molecules involved in several cellular functions such as vascular reactivity, a...
    • P2Y receptors, organism-specific biosystem (from REACTOME)
      P2Y receptors, organism-specific biosystemP2Y receptors are a family of purinergic receptors, G protein-coupled receptors stimulated by nucleotides such as ATP, ADP, UTP, UDP and UDP-glucose. To date, 12 P2Y receptors have been cloned in hum...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA0001

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein coupled purinergic nucleotide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    UDP-activated nucleotide receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    G-protein coupled purinergic nucleotide receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    G-protein coupled receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    P2Y purinoceptor 14
    Names
    G protein coupled receptor for UDP-glucose
    G-protein coupled receptor 105
    P2Y(14) receptor
    P2Y14 receptor
    UDP-glucose receptor
    purinergic receptor P2Y, G-protein coupled, 14

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081455.1NP_001074924.1  P2Y purinoceptor 14

      See identical proteins and their annotated locations for NP_001074924.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC078816, BC034989, CD110153
      Consensus CDS
      CCDS3156.1
      UniProtKB/Swiss-Prot
      Q15391
      UniProtKB/TrEMBL
      A5JUU3
      Related
      ENSP00000408733.2, OTTHUMP00000216779, ENST00000424796.6, OTTHUMT00000357790
      Conserved Domains (2) summary
      pfam00001
      Location:40295
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:34235
      7tm_4; Olfactory receptor
    2. NM_014879.3NP_055694.3  P2Y purinoceptor 14

      See identical proteins and their annotated locations for NP_055694.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC078816, BC034989
      Consensus CDS
      CCDS3156.1
      UniProtKB/Swiss-Prot
      Q15391
      UniProtKB/TrEMBL
      A5JUU3
      Related
      ENSP00000308361.3, OTTHUMP00000216778, ENST00000309170.7, OTTHUMT00000357789
      Conserved Domains (2) summary
      pfam00001
      Location:40295
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:34235
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

      Range
      151212115..151279165 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011513340.2XP_011511642.1  P2Y purinoceptor 14 isoform X1

      See identical proteins and their annotated locations for XP_011511642.1

      UniProtKB/Swiss-Prot
      Q15391
      UniProtKB/TrEMBL
      A5JUU3
      Conserved Domains (2) summary
      pfam00001
      Location:40295
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:34235
      7tm_4; Olfactory receptor
    2. XM_017007583.1XP_016863072.1  P2Y purinoceptor 14 isoform X1

      UniProtKB/Swiss-Prot
      Q15391
      UniProtKB/TrEMBL
      A5JUU3
      Conserved Domains (2) summary
      pfam00001
      Location:40295
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:34235
      7tm_4; Olfactory receptor
    3. XM_005247922.3XP_005247979.1  P2Y purinoceptor 14 isoform X1

      See identical proteins and their annotated locations for XP_005247979.1

      UniProtKB/Swiss-Prot
      Q15391
      UniProtKB/TrEMBL
      A5JUU3
      Conserved Domains (2) summary
      pfam00001
      Location:40295
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:34235
      7tm_4; Olfactory receptor
    4. XM_005247923.3XP_005247980.1  P2Y purinoceptor 14 isoform X1

      See identical proteins and their annotated locations for XP_005247980.1

      UniProtKB/Swiss-Prot
      Q15391
      UniProtKB/TrEMBL
      A5JUU3
      Conserved Domains (2) summary
      pfam00001
      Location:40295
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:34235
      7tm_4; Olfactory receptor

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      150893105..150959426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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