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    Atf2 activating transcription factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 11909, updated on 4-Jun-2017
    Official Symbol
    Atf2provided by MGI
    Official Full Name
    activating transcription factor 2provided by MGI
    Primary source
    MGI:MGI:109349
    See related
    Ensembl:ENSMUSG00000027104 Vega:OTTMUSG00000013179
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mXBP; Atf-2; Creb2; CRE-BP; D18875; D130078H02Rik; Tg(Gzma-Klra1)7Wum
    Orthologs
    Location:
    2; 2 C3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (73816509..73892639, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (73654578..73730685, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31264 Neighboring gene chimerin 1, opposite strand 3 Neighboring gene chimerin 1 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9) Neighboring gene predicted gene, 39851

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC105211, MGC105222

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II activating transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II distal enhancer sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    cAMP response element binding ISO
    Inferred from Sequence Orthology
    more info
     
    cAMP response element binding protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enhancer sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    adipose tissue development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    amelogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    fat cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    intra-S DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    outflow tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mitochondrial membrane permeability involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transforming growth factor beta2 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    site of double-strand break IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    cyclic AMP-dependent transcription factor ATF-2
    Names
    cAMP response element-binding protein CRE-BP1
    cAMP-dependent transcription factor ATF-2
    NP_001020264.1
    NP_001271298.1
    NP_001271299.1
    NP_001271300.1
    NP_001271301.1
    NP_001271302.1
    NP_001271303.1
    NP_001271305.1
    NP_033845.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025093.2NP_001020264.1  cyclic AMP-dependent transcription factor ATF-2 isoform 1

      See identical proteins and their annotated locations for NP_001020264.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
      Source sequence(s)
      AK051591, AL844581, AL845523, BC079883, BC082596
      Consensus CDS
      CCDS16134.1
      UniProtKB/Swiss-Prot
      P16951
      UniProtKB/TrEMBL
      Q543G2, Q640L6, Q68FE3
      Related
      ENSMUSP00000058521.5, OTTMUSP00000014184, ENSMUST00000055833.11, OTTMUST00000031835
      Conserved Domains (3) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:336396
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. NM_001284369.1NP_001271298.1  cyclic AMP-dependent transcription factor ATF-2 isoform 2

      See identical proteins and their annotated locations for NP_001271298.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1. Variants 2 and 3 encode the same protein.
      Source sequence(s)
      AK035438, AK139515, AL844581, AL845523
      Consensus CDS
      CCDS16135.1
      UniProtKB/TrEMBL
      Q543G2, Q8CBR9
      Related
      ENSMUSP00000107641.2, OTTMUSP00000014186, ENSMUST00000112010.8, OTTMUST00000031838
      Conserved Domains (2) summary
      cd12192
      Location:944
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:296356
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    3. NM_001284370.1NP_001271299.1  cyclic AMP-dependent transcription factor ATF-2 isoform 4

      See identical proteins and their annotated locations for NP_001271299.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an exon and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 5 and 6 encode the same protein.
      Source sequence(s)
      AK035438, AK146839, AL844581, BY474294
      UniProtKB/TrEMBL
      Q8CBR9
      Conserved Domains (3) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:336377
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]
    4. NM_001284371.1NP_001271300.1  cyclic AMP-dependent transcription factor ATF-2 isoform 4

      See identical proteins and their annotated locations for NP_001271300.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks an exon, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 5 and 6 encode the same protein.
      Source sequence(s)
      AK035438, AK146839, AL844581, BY474294
      UniProtKB/TrEMBL
      Q8CBR9
      Related
      ENSMUSP00000133632.1, OTTMUSP00000053457, ENSMUST00000173010.7, OTTMUST00000095769
      Conserved Domains (3) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:336377
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]
    5. NM_001284372.1NP_001271301.1  cyclic AMP-dependent transcription factor ATF-2 isoform 5

      See identical proteins and their annotated locations for NP_001271301.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks two alternate in-frame exons compared to variant 1. The resulting protein (isoform 5) is shorter compared to isoform 1.
      Source sequence(s)
      AL844581, AL845523
      Consensus CDS
      CCDS71076.1
      UniProtKB/TrEMBL
      Q640L6
      Conserved Domains (3) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:238298
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]
    6. NM_001284373.1NP_001271302.1  cyclic AMP-dependent transcription factor ATF-2 isoform 5

      See identical proteins and their annotated locations for NP_001271302.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and lacks two alternate in-frame exons compared to variant 1. The resulting protein (isoform 5) is shorter compared to isoform 1.
      Source sequence(s)
      AL844581, BC079883, BC082596
      Consensus CDS
      CCDS71076.1
      UniProtKB/TrEMBL
      Q640L6, Q68FE3
      Related
      ENSMUSP00000107647.2, OTTMUSP00000014180, ENSMUST00000112016.8, OTTMUST00000031831
      Conserved Domains (3) summary
      cd12192
      Location:4784
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:238298
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
      sd00019
      Location:931
      ZF_C2H2; C2H2 Zn finger [structural motif]
    7. NM_001284374.1NP_001271303.1  cyclic AMP-dependent transcription factor ATF-2 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and lacks a 5' exon compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG. The resulting protein (isoform 6) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AL844581, AL845523, BC082596, BC085137
      UniProtKB/TrEMBL
      Q640L6
      Conserved Domains (1) summary
      cd14687
      Location:101161
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    8. NM_001284376.1NP_001271305.1  cyclic AMP-dependent transcription factor ATF-2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon, contains an alternate in-frame exon and uses a downstream start codon compared to variant 1. The resulting protein (isoform 3) is shorter compared to isoform 1.
      Source sequence(s)
      AL844581, AL845523, BC079883, BC082596
      UniProtKB/TrEMBL
      Q640L6, Q68FE3
      Conserved Domains (2) summary
      cd12192
      Location:944
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:289349
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    9. NM_009715.3NP_033845.1  cyclic AMP-dependent transcription factor ATF-2 isoform 2

      See identical proteins and their annotated locations for NP_033845.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.. Variants 2 and 3 encode the same protein.
      Source sequence(s)
      AK051591, AL844581, AL845523, BC079883
      Consensus CDS
      CCDS16135.1
      UniProtKB/TrEMBL
      Q543G2, Q68FE3
      Related
      ENSMUSP00000107638.1, OTTMUSP00000014181, ENSMUST00000112007.7, OTTMUST00000031832
      Conserved Domains (2) summary
      cd12192
      Location:944
      GCN4_cent; GCN4 central activation domain-like acidic activation domain
      cd14687
      Location:296356
      bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      73816509..73892639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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