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    ALOX15 arachidonate 15-lipoxygenase [ Homo sapiens (human) ]

    Gene ID: 246, updated on 3-Dec-2017
    Official Symbol
    ALOX15provided by HGNC
    Official Full Name
    arachidonate 15-lipoxygenaseprovided by HGNC
    Primary source
    HGNC:HGNC:433
    See related
    Ensembl:ENSG00000161905 MIM:152392; Vega:OTTHUMG00000090746
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LOG15; 12-LOX; 15-LOX; 15-LOX-1
    Summary
    This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on various polyunsaturated fatty acid substrates to generate various bioactive lipid mediators such as eicosanoids, hepoxilins, lipoxins, and other molecules. The encoded enzyme and its reaction products have been shown to regulate inflammation and immunity. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]
    Expression
    Biased expression in lung (RPKM 5.0), small intestine (RPKM 1.7) and 11 other tissues See more
    Orthologs
    Location:
    17p13.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (4630919..4641665, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4534214..4545583, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1996 Neighboring gene uncharacterized LOC105371498 Neighboring gene RNA, U6 small nuclear 955, pseudogene Neighboring gene uncharacterized LOC105371499 Neighboring gene proline, glutamate and leucine rich protein 1 Neighboring gene uncharacterized LOC101559451

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Arachidonic acid metabolism, organism-specific biosystem (from KEGG)
      Arachidonic acid metabolism, organism-specific biosystem
      Arachidonic acid metabolism
    • Arachidonic acid metabolism, organism-specific biosystem (from REACTOME)
      Arachidonic acid metabolism, organism-specific biosystemEicosanoids, oxygenated, 20-carbon fatty acids, are autocrine and paracrine signaling molecules that modulate physiological processes including pain, fever, inflammation, blood clot formation, smooth...
    • Arachidonic acid metabolism, conserved biosystem (from KEGG)
      Arachidonic acid metabolism, conserved biosystem
      Arachidonic acid metabolism
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Eicosanoid Synthesis, organism-specific biosystem (from WikiPathways)
      Eicosanoid Synthesis, organism-specific biosystemIn biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or i...
    • Ferroptosis, organism-specific biosystem (from KEGG)
      Ferroptosis, organism-specific biosystemFerroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compou...
    • Ferroptosis, conserved biosystem (from KEGG)
      Ferroptosis, conserved biosystemFerroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compou...
    • IL4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL4-mediated signaling events, organism-specific biosystem
      IL4-mediated signaling events
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interleukin-4 and 13 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-4 and 13 signaling, organism-specific biosystemInterleukin-4 (IL4) is a principal regulatory cytokine during the immune response, crucially important in allergy and asthma (Nelms et al. 1999). When resting T cells are antigen-activated and expand...
    • Linoleic acid metabolism, organism-specific biosystem (from KEGG)
      Linoleic acid metabolism, organism-specific biosystem
      Linoleic acid metabolism
    • Linoleic acid metabolism, conserved biosystem (from KEGG)
      Linoleic acid metabolism, conserved biosystem
      Linoleic acid metabolism
    • Metabolic pathways, organism-specific biosystem (from KEGG)
      Metabolic pathways, organism-specific biosystem
      Metabolic pathways
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Serotonergic synapse, organism-specific biosystem (from KEGG)
      Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Synthesis of 12-eicosatetraenoic acid derivatives, organism-specific biosystem (from REACTOME)
      Synthesis of 12-eicosatetraenoic acid derivatives, organism-specific biosystemThe 12-eicosatetraenoic acids: 12-hydroperoxy-eicosatetraenoic acid (12-HpETE), 12-hydroxyeicosatetraenoic acid (12-HETE) and 12-oxo-eicosatetraenoic acid (12-oxoETE) are formed after the initial ste...
    • Synthesis of 15-eicosatetraenoic acid derivatives, organism-specific biosystem (from REACTOME)
      Synthesis of 15-eicosatetraenoic acid derivatives, organism-specific biosystemThe 15-eicosatetraenoic acids: 15-hydroperoxy-eicosatetraenoic acid (15-HpETE), 15-hydroxyeicosatetraenoic acid (15-HETE) and 15-oxo-eicosatetraenoic acid (15-oxoETE) are formed after the initial st...
    • Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystem (from REACTOME)
      Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystemLeukotrienes (LTs) are biologically active molecules formed in response to inflammatory stimuli. They cause contraction of bronchial smooth muscles, stimulation of vascular permeability, and attracti...
    • lipoxin biosynthesis, organism-specific biosystem (from BIOCYC)
      lipoxin biosynthesis, organism-specific biosystemGeneral Background Lipoxins belong to the eicosanoid family, have a distinct conjugated tetraene structure and are generated from : ARACHIDONIC_ACID during inflammation. They consist of two distinct...
    • lipoxin biosynthesis, conserved biosystem (from BIOCYC)
      lipoxin biosynthesis, conserved biosystemGeneral Background Lipoxins belong to the eicosanoid family, have a distinct conjugated tetraene structure and are generated from |FRAME: ARACHIDONIC_ACID| during inflammation. They consist of two d...
    • resolvin D biosynthesis, organism-specific biosystem (from BIOCYC)
      resolvin D biosynthesis, organism-specific biosystemGeneral Background The ω 3 polyunsaturated fatty acids are known to be essential for proper neuronal and immune function. Deficiencies in these important fatty acids are associated with mental...
    • resolvin D biosynthesis, conserved biosystem (from BIOCYC)
      resolvin D biosynthesis, conserved biosystemGeneral Background The ω 3 polyunsaturated fatty acids are essential for proper neuronal and immune function. Deficiencies in these important fatty acids are associated with mental dysfunction...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    arachidonate 12-lipoxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    arachidonate 12-lipoxygenase activity TAS
    Traceable Author Statement
    more info
     
    arachidonate 15-lipoxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    arachidonate 15-lipoxygenase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    arachidonate 15-lipoxygenase activity TAS
    Traceable Author Statement
    more info
     
    eoxin A4 synthase activity TAS
    Traceable Author Statement
    more info
     
    hepoxilin A3 synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hepoxilin-epoxide hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    iron ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic cell clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    arachidonic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    arachidonic acid metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    bone mineralization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to interleukin-13 IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hepoxilin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    leukotriene metabolic process TAS
    Traceable Author Statement
    more info
     
    lipoxin A4 biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lipoxygenase pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipoxygenase pathway TAS
    Traceable Author Statement
    more info
     
    negative regulation of adaptive immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ossification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylethanolamine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of actin filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell-substrate adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of heterotypic cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of engulfment of apoptotic cell ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of peroxisome proliferator activated receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    wound healing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    arachidonate 15-lipoxygenase
    Names
    12/15-lipoxygenase
    15-LOX type 1
    15-lipooxygenase-1
    15-lipoxygenase type 1
    arachidonate 12-lipoxygenase, leukocyte-type
    arachidonate omega-6 lipoxygenase
    NP_001131.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001140.4NP_001131.3  arachidonate 15-lipoxygenase

      See identical proteins and their annotated locations for NP_001131.3

      Status: REVIEWED

      Source sequence(s)
      BC029032, DC346318, M23892
      Consensus CDS
      CCDS11049.1
      UniProtKB/Swiss-Prot
      P16050
      Related
      ENSP00000293761.3, ENST00000293761.7
      Conserved Domains (2) summary
      cd01753
      Location:2111
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      pfam00305
      Location:219653
      Lipoxygenase; Lipoxygenase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      4630919..4641665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      4542997..4553746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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