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    PRKCD protein kinase C delta [ Homo sapiens (human) ]

    Gene ID: 5580, updated on 3-Dec-2017
    Official Symbol
    PRKCDprovided by HGNC
    Official Full Name
    protein kinase C deltaprovided by HGNC
    Primary source
    HGNC:HGNC:9399
    See related
    Ensembl:ENSG00000163932 MIM:176977; Vega:OTTHUMG00000133659
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MAY1; PKCD; ALPS3; CVID9; nPKC-delta
    Summary
    The protein encoded by this gene is a member of the protein kinase C family of serine- and threonine-specific protein kinases. The encoded protein is activated by diacylglycerol and is both a tumor suppressor and a positive regulator of cell cycle progression. Also, this protein can positively or negatively regulate apoptosis. Defects in this gene are a cause of autoimmune lymphoproliferative syndrome. [provided by RefSeq, Aug 2017]
    Expression
    Ubiquitous expression in adrenal (RPKM 23.1), bone marrow (RPKM 21.7) and 25 other tissues See more
    Orthologs
    Location:
    3p21.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (53161207..53192717)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (53195223..53226733)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene SERPINE1 mRNA binding protein 1 pseudogene 3 Neighboring gene RFT1 homolog Neighboring gene transketolase Neighboring gene uncharacterized LOC107986087 Neighboring gene decapping mRNA 1A

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Autoimmune lymphoproliferative syndrome, type III
    MedGen: C3809928 OMIM: 615559 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog
    Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 activates forward trafficking and surface clustering of NMDA receptors in membrane microdomains by a PKA-dependent phosphorylation of the NR1 C-terminal Ser897, followed by a PKC-dependent phosphorylation of Ser896 PubMed
    env Down modulation of the interaction between HIV-1 gp120 and CD4 by TPA is blocked by protein kinase C (PKC) inhibitors, suggesting PKC may play an important role in HIV-1 infection PubMed
    env c-FLIPL inhibits Bax activation via modulating PKC expression at the transcriptional level involving AP-2 during gp120 treatment PubMed
    env Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways PubMed
    env Induction of apoptosis in cell cultures through binding of HIV-1 gp120 or gp160 to CXCR4 involves protein kinase C, basic fibroblast growth factor, caspase-3, and the pro-apoptotic molecule Bax PubMed
    env HIV-1 gp120 increases the levels of calcium-dependent and -independent PKC isozymes; the most striking change is observed in PKC-zeta isozyme levels PubMed
    env A specific interaction between CD4 and HIV-1 gp120 is required for phosphorylation of CD4, which could involve protein kinase C PubMed
    env IL-16 induces rapid translocation of PKC from the cytosol to the membrane in CD4+ cells; PKC inhibitors completely block IL-16-induced lymphocyte migration as well as the motile response induced by HIV-1 gp120 and anti-CD4 antibody binding to CD4 PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160-induced AP-1 complex formation is dependent upon protein tyrosine phosphorylation and is abolished by inhibitors of protein kinase C, but it is unaffected by calcium channel blockers or cyclosporine A PubMed
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to cytoplasmic domain residues 828-848 of HIV-1 gp41 inhibits pKC-catalysed phosphorylation of a protein substrate PubMed
    env A synthetic peptide containing residues 581-597 from HIV-1 gp41 inhibits protein kinase C (pkC)-mediated phosphorylation of the CD3 gamma-chain in intact cells and directly inhibits partially purified pkC PubMed
    Nef nef The Nef/hnRNPK/PKC-delta/Hck protein complex activates Pak2 activity but inhibits Pak1 activity, which induces paxillin phosphorylation on Ser272/274 and regulates paxillin/TACE association and secretion PubMed
    nef The Nef/hnRNPK/PKC-delta/Hck protein complex increases paxillin phosphorylation at Y118 and activates and secretes TACE through Erk1/2 activation PubMed
    nef In the context of Nef-associated kinase complex (NAKC), hnRNP-K interacts with HIV-1 Nef and recruits LCK, PKCdelta, and PI-3 kinase PubMed
    Tat tat Phospholipase C/protein kinase C signaling pathway-dependent phosphorylation of p44/42 and JNK MAP kinases participates partially in IL-1beta induction by TAT PubMed
    tat Tat-triggered PKCdelta and PKCtheta activation results in the downstream signaling through the apoptosis pathways mediated by both ERK1/2 and caspase-3 PubMed
    tat HIV-1 Tat-mediated stimulation of IL-10 production through the activation of PKC delta, but not TNF-alpha, requires p38 MAP kinase in human macrophages PubMed
    tat HIV-1 Tat-mediated stimulation of IL-10 and TNF-alpha production through the activation of PKC delta requires ERK1/2 MAP kinase and NF-kappaB transcription factor in human macrophages PubMed
    tat Protein kinase C is required for HIV-1 Tat-mediated transactivation of the viral LTR promoter, indicating protein kinase C regulates the process of HIV-1 transactivation and may play a role in the transition of HIV from latency to productive growth PubMed
    tat Protein kinase C phosphorylates HIV-1 Tat on serine residue 46 PubMed
    tat HIV-1 Tat activates protein kinase C, resulting in the induction of TNF-alpha, IL-6 and IL-10 expression and the secretion of MCP-1 PubMed
    matrix gag Protein kinase C (PKC) phosphorylates HIV-1 Matrix on serine residue 111 resulting in a shift in localization of Matrix from the cytosol to the cellular membrane, suggesting a myristoyl-protein switch regulated by PKC phosphorylation PubMed
    retropepsin gag-pol Phosphorylation of human recombinant vimentin by PKC inhibits the proteolytic processing of the vimentin head domain by HIV-1 protease PubMed
    reverse transcriptase gag-pol HIV-1 RT heterodimer expressed in bacteria can be phosphorylated in vitro by several purified mammalian protein kinases including auto-activated protein kinase (PK), CKII, cytosolic protamine kinase (CPK), myelin basic protein kinase 1 (MBPK1), and PRKC PubMed

    Go to the HIV-1, Human Interaction Database

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      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
      Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signaling by PDGF, organism-specific biosystem (from REACTOME)
      Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
    • Signaling by VEGF, organism-specific biosystem (from REACTOME)
      Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Syndecan-2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Syndecan-2-mediated signaling events, organism-specific biosystem
      Syndecan-2-mediated signaling events
    • Syndecan-4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Syndecan-4-mediated signaling events, organism-specific biosystem
      Syndecan-4-mediated signaling events
    • T-Cell antigen Receptor (TCR) Signaling Pathway, organism-specific biosystem (from WikiPathways)
      T-Cell antigen Receptor (TCR) Signaling Pathway, organism-specific biosystemThe T-cell antigen receptor (TCR) complex is composed of a ligand-binding subunit, the ? and ? chains, and a signaling subunit, namely the CD3?, ? and ? chains and the TCR? chain. This complex partic...
    • Thromboxane A2 receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      Thromboxane A2 receptor signaling, organism-specific biosystem
      Thromboxane A2 receptor signaling
    • Trk receptor signaling mediated by PI3K and PLC-gamma, organism-specific biosystem (from Pathway Interaction Database)
      Trk receptor signaling mediated by PI3K and PLC-gamma, organism-specific biosystem
      Trk receptor signaling mediated by PI3K and PLC-gamma
    • Trk receptor signaling mediated by the MAPK pathway, organism-specific biosystem (from Pathway Interaction Database)
      Trk receptor signaling mediated by the MAPK pathway, organism-specific biosystem
      Trk receptor signaling mediated by the MAPK pathway
    • Type II diabetes mellitus, organism-specific biosystem (from KEGG)
      Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
    • Type II diabetes mellitus, conserved biosystem (from KEGG)
      Type II diabetes mellitus, conserved biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
    • Type II diabetes mellitus, organism-specific biosystem (from WikiPathways)
      Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
    • Type II interferon signaling (IFNG), organism-specific biosystem (from WikiPathways)
      Type II interferon signaling (IFNG), organism-specific biosystemAdapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several ...
    • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
      VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
    • VEGFR2 mediated cell proliferation, organism-specific biosystem (from REACTOME)
      VEGFR2 mediated cell proliferation, organism-specific biosystemVEGFR2 stimulates ERK not via GRB2-SOS-RAS, but via pY1175-dependent phosphorylation of PLC gamma and subsequent activation of PKCs. PKC plays an important mediatory role in the proliferative Ras/Raf...
    • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
      Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
      Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • Wnt Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...
    • miRs in Muscle Cell Differentiation, organism-specific biosystem (from WikiPathways)
      miRs in Muscle Cell Differentiation, organism-specific biosystem
      miRs in Muscle Cell Differentiation
    • p53 pathway, organism-specific biosystem (from Pathway Interaction Database)
      p53 pathway, organism-specific biosystem
      p53 pathway
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC49908

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-independent protein kinase C activity EXP
    Inferred from Experiment
    more info
    PubMed 
    calcium-independent protein kinase C activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    insulin receptor substrate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase C activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein kinase C activity TAS
    Traceable Author Statement
    more info
     
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
     
    activation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to angiotensin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hydrogen peroxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hydroperoxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular senescence IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    execution phase of apoptosis TAS
    Traceable Author Statement
    more info
     
    histone phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    immunoglobulin mediated immune response IEA
    Inferred from Electronic Annotation
    more info
     
    interferon-gamma-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    interleukin-10 production IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-12 production IEA
    Inferred from Electronic Annotation
    more info
     
    intrinsic apoptotic signaling pathway in response to oxidative stress TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of MAP kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of actin filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of filopodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of glial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of inflammatory response IC
    Inferred by Curator
    more info
    PubMed 
    negative regulation of insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of insulin receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of platelet aggregation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    neutrophil activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    platelet activation TAS
    Traceable Author Statement
    more info
     
    positive regulation of apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ceramide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endodeoxyribonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of glucosylceramide catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of phospholipid scramblase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of sphingomyelin catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of superoxide anion generation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein stabilization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mRNA stability TAS
    Traceable Author Statement
    more info
     
    regulation of receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    stimulatory C-type lectin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    termination of signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    azurophil granule lumen TAS
    Traceable Author Statement
    more info
     
    cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    protein kinase C delta type
    Names
    protein kinase C delta VIII
    tyrosine-protein kinase PRKCD
    NP_001303256.1
    NP_006245.2
    NP_997704.1
    XP_006713320.1
    XP_006713322.1
    XP_016862344.1
    XP_016862345.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033864.1 RefSeqGene

      Range
      5001..36511
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316327.1NP_001303256.1  protein kinase C delta type

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 6, and 7 all encode the same isoform (c).
      Source sequence(s)
      AC097015, AK294272, AK313216, AW293041, BC043350
      Consensus CDS
      CCDS2870.1
      UniProtKB/Swiss-Prot
      Q05655
      UniProtKB/TrEMBL
      A0A024R328, B4DFV1
      Conserved Domains (2) summary
      cd05620
      Location:353668
      STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta
      pfam00130
      Location:231283
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    2. NM_001354676.1NP_001341605.1  protein kinase C delta type isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (a).
      Source sequence(s)
      AC097015
      Conserved Domains (2) summary
      cd05620
      Location:372687
      STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta
      pfam00130
      Location:250302
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    3. NM_001354678.1NP_001341607.1  protein kinase C delta type isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice junction compared to variant 4. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC097015
      Conserved Domains (2) summary
      cd05620
      Location:369684
      STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta
      pfam00130
      Location:247299
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    4. NM_001354679.1NP_001341608.1  protein kinase C delta type isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 6, and 7 all encode the same isoform (c).
      Source sequence(s)
      AC097015
      Conserved Domains (2) summary
      cd05620
      Location:353668
      STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta
      pfam00130
      Location:231283
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    5. NM_001354680.1NP_001341609.1  protein kinase C delta type isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 6, and 7 all encode the same isoform (c).
      Source sequence(s)
      AC097015
      Conserved Domains (2) summary
      cd05620
      Location:353668
      STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta
      pfam00130
      Location:231283
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    6. NM_006254.3NP_006245.2  protein kinase C delta type

      See identical proteins and their annotated locations for NP_006245.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 6, and 7 all encode the same isoform (c).
      Source sequence(s)
      AW293041, BC043350, BE048101, CD369320, L07861
      Consensus CDS
      CCDS2870.1
      UniProtKB/Swiss-Prot
      Q05655
      UniProtKB/TrEMBL
      A0A024R328
      Related
      ENSP00000331602.3, OTTHUMP00000165025, ENST00000330452.7, OTTHUMT00000257819
      Conserved Domains (2) summary
      cd05620
      Location:353668
      STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta
      pfam00130
      Location:231283
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    7. NM_212539.1NP_997704.1  protein kinase C delta type

      See identical proteins and their annotated locations for NP_997704.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 1, 2, 3, 6, and 7 all encode the same isoform (c).
      Source sequence(s)
      AW293041, BC043350, BE048101, CD369320, L07861
      Consensus CDS
      CCDS2870.1
      UniProtKB/Swiss-Prot
      Q05655
      UniProtKB/TrEMBL
      A0A024R328
      Related
      ENSP00000378217.2, OTTHUMP00000165024, ENST00000394729.6, OTTHUMT00000257818
      Conserved Domains (2) summary
      cd05620
      Location:353668
      STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta
      pfam00130
      Location:231283
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

      Range
      53161207..53192717
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006713259.2XP_006713322.1  protein kinase C delta type isoform X1

      UniProtKB/Swiss-Prot
      Q05655
      UniProtKB/TrEMBL
      A0A024R328
      Conserved Domains (2) summary
      cd05620
      Location:353668
      STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta
      pfam00130
      Location:231283
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    2. XM_017006856.1XP_016862345.1  protein kinase C delta type isoform X1

      UniProtKB/Swiss-Prot
      Q05655
      UniProtKB/TrEMBL
      A0A024R328
      Conserved Domains (2) summary
      cd05620
      Location:353668
      STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta
      pfam00130
      Location:231283
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    3. XM_006713257.3XP_006713320.1  protein kinase C delta type isoform X2

      Conserved Domains (2) summary
      cd05620
      Location:369684
      STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta
      pfam00130
      Location:247299
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    4. XM_017006855.1XP_016862344.1  protein kinase C delta type isoform X1

      UniProtKB/Swiss-Prot
      Q05655
      UniProtKB/TrEMBL
      A0A024R328
      Conserved Domains (2) summary
      cd05620
      Location:353668
      STKc_nPKC_delta; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta
      pfam00130
      Location:231283
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    RNA

    1. XR_940474.2 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      53146796..53178291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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