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    Eif4e eukaryotic translation initiation factor 4E [ Mus musculus (house mouse) ]

    Gene ID: 13684, updated on 9-May-2017
    Official Symbol
    Eif4eprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4Eprovided by MGI
    Primary source
    MGI:MGI:95305
    See related
    Ensembl:ENSMUSG00000028156 Vega:OTTMUSG00000052912
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    If4e; eIF-4E; EG668879; Eif4e-ps
    Summary
    This gene encodes a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. It has also been associated with autism spectrum disorders. Consistently, knockout of this gene results in increased translation of neuroligins, postsynaptic proteins linked to autism spectrum disorders. Pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Orthologs
    Location:
    3 G3; 3 64.3 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (138526191..138559696)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (138189155..138220563)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene alcohol dehydrogenase 5 (class III), chi polypeptide Neighboring gene methionyl aminopeptidase 1 Neighboring gene predicted gene, 32553 Neighboring gene microRNA 1956 Neighboring gene predicted gene, 29762 Neighboring gene solute carrier family 5 (sodium-dependent vitamin transporter), member 6 pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC103177

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA 7-methylguanosine cap binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    eukaryotic initiation factor 4G binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    repressing transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    behavioral fear response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to dexamethasone stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    stem cell population maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    translation IEA
    Inferred from Electronic Annotation
    more info
     
    translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    P-body ISO
    Inferred from Sequence Orthology
    more info
     
    RISC complex ISO
    Inferred from Sequence Orthology
    more info
     
    chromatoid body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    eukaryotic translation initiation factor 4F complex ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA cap binding complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA cap binding complex ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    eukaryotic translation initiation factor 4E
    Names
    eIF-4F 25 kDa subunit
    mRNA cap-binding protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313980.1NP_001300909.1  eukaryotic translation initiation factor 4E isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and contains an alternate exon in the 5' coding region that results in use of a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC113988, AK167097, BP770650
      Consensus CDS
      CCDS84679.1
      UniProtKB/TrEMBL
      A0A0G2JFB4, Q3TK95
      Related
      ENSMUSP00000143104.1, OTTMUSP00000070606, ENSMUST00000196990.4, OTTMUST00000132424
      Conserved Domains (1) summary
      pfam01652
      Location:2112
      IF4E; Eukaryotic initiation factor 4E
    2. NM_007917.4NP_031943.3  eukaryotic translation initiation factor 4E isoform 1

      See identical proteins and their annotated locations for NP_031943.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC113988, AK082867, AK167097, BP770650, CN714483
      Consensus CDS
      CCDS38654.1
      UniProtKB/Swiss-Prot
      P63073
      UniProtKB/TrEMBL
      Q3TK95, Q8C470
      Related
      ENSMUSP00000029803.7, OTTMUSP00000070604, ENSMUST00000029803.11, OTTMUST00000132422
      Conserved Domains (1) summary
      pfam01652
      Location:41197
      IF4E; Eukaryotic initiation factor 4E

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      138526191..138559696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500993.3XP_006501056.1  eukaryotic translation initiation factor 4E isoform X1

      Related
      ENSMUSP00000143772.1, OTTMUSP00000070608, ENSMUST00000200100.1, OTTMUST00000132426
      Conserved Domains (1) summary
      pfam01652
      Location:54210
      IF4E; Eukaryotic initiation factor 4E
    2. XM_017319453.1XP_017174942.1  eukaryotic translation initiation factor 4E isoform X2

      UniProtKB/TrEMBL
      A0A0G2JFB4
      Conserved Domains (1) summary
      pfam01652
      Location:2112
      IF4E; Eukaryotic initiation factor 4E
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