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    STK38 serine/threonine kinase 38 [ Homo sapiens (human) ]

    Gene ID: 11329, updated on 6-Dec-2016
    Official Symbol
    STK38provided by HGNC
    Official Full Name
    serine/threonine kinase 38provided by HGNC
    Primary source
    HGNC:HGNC:17847
    See related
    Ensembl:ENSG00000112079 MIM:606964; Vega:OTTHUMG00000014598
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NDR; NDR1
    Summary
    This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
    Orthologs
    Location:
    6p21.31
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (36493882..36547516, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (36461666..36515256, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375037 Neighboring gene peroxisomal, testis specific 1 Neighboring gene RNA, 7SL, cytoplasmic 502, pseudogene Neighboring gene potassium channel tetramerization domain containing 20 Neighboring gene RNA, 7SL, cytoplasmic 748, pseudogene Neighboring gene serine and arginine rich splicing factor 3 Neighboring gene microRNA 3925

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol Two related serine-threonine kinases, nuclear Dbf2 related 1 (NDR1) and NDR2, are incorporated into HIV-1 particles and are cleaved by the HIV-1 protease (PR), both within virions and within producer cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ38018

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cadherin binding involved in cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitogen-activated protein kinase kinase kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular protein modification process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    MLL5-L complex IDA
    Inferred from Direct Assay
    more info
     
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    serine/threonine-protein kinase 38
    Names
    NDR1 protein kinase
    Ndr Ser/Thr kinase-like protein
    nuclear Dbf2-related kinase 1
    NP_001292031.1
    NP_009202.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305102.1NP_001292031.1  serine/threonine-protein kinase 38

      See identical proteins and their annotated locations for NP_001292031.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC012085, BC095413, CB852856, DA459946
      Consensus CDS
      CCDS4822.1
      UniProtKB/Swiss-Prot
      Q15208
      UniProtKB/TrEMBL
      A0A024RD18
      Conserved Domains (2) summary
      smart00220
      Location:89382
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05628
      Location:87462
      STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1
    2. NM_007271.3NP_009202.1  serine/threonine-protein kinase 38

      See identical proteins and their annotated locations for NP_009202.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC012085, CB852856, DA459946
      Consensus CDS
      CCDS4822.1
      UniProtKB/Swiss-Prot
      Q15208
      UniProtKB/TrEMBL
      A0A024RD18
      Related
      ENSP00000229812, OTTHUMP00000016293, ENST00000229812, OTTHUMT00000040346
      Conserved Domains (2) summary
      smart00220
      Location:89382
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05628
      Location:87462
      STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

      Range
      36493882..36547516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010226.1XP_016865715.1  

      Conserved Domains (2) summary
      smart00220
      Location:89382
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:87424
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006714989.3XP_006715052.1  

      See identical proteins and their annotated locations for XP_006715052.1

      UniProtKB/Swiss-Prot
      Q15208
      UniProtKB/TrEMBL
      A0A024RD18
      Conserved Domains (2) summary
      smart00220
      Location:89382
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05628
      Location:87462
      STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1
    3. XM_006714988.3XP_006715051.1  

      See identical proteins and their annotated locations for XP_006715051.1

      UniProtKB/Swiss-Prot
      Q15208
      UniProtKB/TrEMBL
      A0A024RD18
      Conserved Domains (2) summary
      smart00220
      Location:89382
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05628
      Location:87462
      STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1

    RNA

    1. XR_001743146.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      36463457..36517091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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