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    flavivirus polyprotein gene flavivirus polyprotein [ Dengue virus 2 ]

    Gene ID: 1494449, updated on 5-Oct-2016
    Gene symbol
    flavivirus polyprotein gene
    Gene description
    flavivirus polyprotein
    Locus tag
    DENV_gp1
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Dengue virus 2 (strain: 16681, old-name: Dengue virus type 2)
    Lineage
    Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage; Flaviviridae; Flavivirus; Dengue virus group
    Sequence:
    NC_001474.2 (97..10272)

    NC_001474.2Genomic Context describing neighboring genes

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description
    Names
    flavivirus polyprotein
    anchored capsid protein C
    capsid protein C
    membrane glycoprotein precursor M
    membrane glycoprotein M
    envelope protein E
    nonstructural protein NS1
    nonstructural protein NS2A
    nonstructural protein NS2B
    nonstructural protein NS3
    nonstructural protein NS4A
    protein 2K
    nonstructural protein NS4B
    RNA-dependent RNA polymerase NS5
    protein pr
    NP_056776.2
    • contains structural proteins, C-prM/M-E and non-structural proteins, NS1-NS2A/B-NS3-NS4A/B-NS5

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001474.2 Reference assembly

      Range
      97..10272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_056776.2 flavivirus polyprotein [Dengue virus 2]

      See identical proteins and their annotated locations for NP_056776.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A173DS53, O09234
      Conserved Domains (17) summary
      cd12149
      Location:585674
      Flavi_E_C; Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E
      TIGR04240
      Location:679775
      flavi_E_stem; flavivirus envelope glycoprotein E, stem/anchor domain
      smart00487
      Location:16571800
      DEXDc; DEAD-like helicases superfamily
      pfam01003
      Location:5114
      Flavi_capsid; Flavivirus capsid protein C
      pfam00869
      Location:282576
      Flavi_glycoprot; Flavivirus glycoprotein, central and dimerization domains
      pfam00948
      Location:7771130
      Flavi_NS1; Flavivirus non-structural Protein NS1
      pfam00949
      Location:14941642
      Peptidase_S7; Peptidase S7, Flavivirus NS3 serine protease
      pfam00972
      Location:27423380
      Flavi_NS5; Flavivirus RNA-directed RNA polymerase
      pfam01002
      Location:13491475
      Flavi_NS2B; Flavivirus non-structural protein NS2B
      pfam01004
      Location:207280
      Flavi_M; Flavivirus envelope glycoprotein M
      pfam01005
      Location:11381342
      Flavi_NS2A; Flavivirus non-structural protein NS2A
      pfam01349
      Location:22442484
      Flavi_NS4B; Flavivirus non-structural protein NS4B
      pfam01350
      Location:20982240
      Flavi_NS4A; Flavivirus non-structural protein NS4A
      pfam01570
      Location:126204
      Flavi_propep; Flavivirus polyprotein propeptide
      pfam01728
      Location:25462713
      FtsJ; FtsJ-like methyltransferase
      pfam07652
      Location:16601805
      Flavi_DEAD; Flavivirus DEAD domain
      cl21455
      Location:18301939
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NP_739581.2 anchored capsid protein C

      Conserved Domains (1) summary
      pfam01003
      Location:5114
      Flavi_capsid; Flavivirus capsid protein C
    3. NP_739591.2 capsid protein C

      Conserved Domains (1) summary
      pfam01003
      Location:5100
      Flavi_capsid; Flavivirus capsid protein C
    4. NP_739582.2 membrane glycoprotein precursor M

      Conserved Domains (2) summary
      pfam01004
      Location:93166
      Flavi_M; Flavivirus envelope glycoprotein M
      pfam01570
      Location:1290
      Flavi_propep; Flavivirus polyprotein propeptide
    5. NP_739592.2 membrane glycoprotein M

      Conserved Domains (1) summary
      pfam01004
      Location:275
      Flavi_M; Flavivirus envelope glycoprotein M
    6. NP_739583.2 envelope protein E

      Conserved Domains (3) summary
      cd12149
      Location:305394
      Flavi_E_C; Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E
      TIGR04240
      Location:399495
      flavi_E_stem; flavivirus envelope glycoprotein E, stem/anchor domain
      pfam00869
      Location:2296
      Flavi_glycoprot; Flavivirus glycoprotein, central and dimerization domains
    7. NP_739584.2 nonstructural protein NS1

      Conserved Domains (1) summary
      pfam00948
      Location:2352
      Flavi_NS1; Flavivirus non-structural Protein NS1
    8. NP_739585.2 nonstructural protein NS2A

      Conserved Domains (1) summary
      pfam01005
      Location:11215
      Flavi_NS2A; Flavivirus non-structural protein NS2A
    9. NP_739586.2 nonstructural protein NS2B

      Conserved Domains (1) summary
      pfam01002
      Location:4130
      Flavi_NS2B; Flavivirus non-structural protein NS2B
    10. NP_739587.2 nonstructural protein NS3

      Conserved Domains (4) summary
      smart00487
      Location:182325
      DEXDc; DEAD-like helicases superfamily
      pfam00949
      Location:19167
      Peptidase_S7; Peptidase S7, Flavivirus NS3 serine protease
      pfam07652
      Location:185330
      Flavi_DEAD; Flavivirus DEAD domain
      cl21455
      Location:355464
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    11. NP_739588.2 nonstructural protein NS4A

      Conserved Domains (1) summary
      pfam01350
      Location:5127
      Flavi_NS4A; Flavivirus non-structural protein NS4A
    12. NP_739593.2 protein 2K

    13. NP_739589.2 nonstructural protein NS4B

      Conserved Domains (1) summary
      pfam01349
      Location:1241
      Flavi_NS4B; Flavivirus non-structural protein NS4B
    14. NP_739590.2 RNA-dependent RNA polymerase NS5

      Conserved Domains (2) summary
      pfam00972
      Location:251889
      Flavi_NS5; Flavivirus RNA-directed RNA polymerase
      pfam01728
      Location:55222
      FtsJ; FtsJ-like methyltransferase
    15. YP_009164954.1 protein pr

      Conserved Domains (1) summary
      pfam01570
      Location:1290
      Flavi_propep; Flavivirus polyprotein propeptide
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