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    Dsp desmoplakin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306871, updated on 19-Feb-2017
    Official Symbol
    Dspprovided by RGD
    Official Full Name
    desmoplakinprovided by RGD
    Primary source
    RGD:1305794
    See related
    Ensembl:ENSRNOG00000013928
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Orthologs
    Location:
    17p12
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (27286811..27334453, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (29201872..29249490, complement)

    Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556358 Neighboring gene small nuclear ribonucleoprotein U11/U12 subunit 48 Neighboring gene uncharacterized LOC102546383 Neighboring gene uncharacterized LOC103694064

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion molecule binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding, bridging IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding, bridging ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase C binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
     
    scaffold protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    structural molecule activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    adherens junction organization IEA
    Inferred from Electronic Annotation
    more info
     
    adherens junction organization ISO
    Inferred from Sequence Orthology
    more info
     
    bundle of His cell-Purkinje myocyte adhesion involved in cell communication IEA
    Inferred from Electronic Annotation
    more info
     
    bundle of His cell-Purkinje myocyte adhesion involved in cell communication ISO
    Inferred from Sequence Orthology
    more info
     
    desmosome organization IEA
    Inferred from Electronic Annotation
    more info
     
    desmosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    intermediate filament cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    intermediate filament organization IEA
    Inferred from Electronic Annotation
    more info
     
    intermediate filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    keratinocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    peptide cross-linking IEA
    Inferred from Electronic Annotation
    more info
     
    peptide cross-linking ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    protein localization to adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of heart rate by cardiac conduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of heart rate by cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of ventricular cardiac muscle cell action potential IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of ventricular cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    single organismal cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    skin development ISO
    Inferred from Sequence Orthology
    more info
     
    ventricular compact myocardium morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    ventricular compact myocardium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    wound healing IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    NOT adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cornified envelope IEA
    Inferred from Electronic Annotation
    more info
     
    cornified envelope ISO
    Inferred from Sequence Orthology
    more info
     
    desmosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    desmosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    fascia adherens IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intercalated disc ISO
    Inferred from Sequence Orthology
    more info
     
    intermediate filament IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with intermediate filament ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

      Range
      27286811..27334453 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_225259.9XP_225259.4  desmoplakin isoform X1

      See identical proteins and their annotated locations for XP_225259.4

      UniProtKB/TrEMBL
      F1LMV6
      Related
      ENSRNOP00000018649, ENSRNOT00000018649
      Conserved Domains (10) summary
      smart00250
      Location:20912128
      PLEC; Plectin repeat
      cd00176
      Location:292457
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:26562695
      Plectin; Plectin repeat
      pfam09728
      Location:15241839
      Taxilin; Myosin-like coiled-coil protein
      pfam10174
      Location:10321681
      Cast; RIM-binding protein of the cytomatrix active zone
      pfam12761
      Location:15141662
      End3; Actin cytoskeleton-regulatory complex protein END3
      cd16269
      Location:13821393
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:197373
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:13181412
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl24005
      Location:12761349
      DUF2570; Protein of unknown function (DUF2570)
    2. XM_017600713.1XP_017456202.1  desmoplakin isoform X2

    Alternate Rn_Celera

    Genomic

    1. AC_000085.1 Alternate Rn_Celera

      Range
      26257726..26305766 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001058477.6XP_001058477.1  desmoplakin isoform X1

      See identical proteins and their annotated locations for XP_001058477.1

      UniProtKB/TrEMBL
      F1LMV6
      Conserved Domains (10) summary
      smart00250
      Location:20912128
      PLEC; Plectin repeat
      cd00176
      Location:292457
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:26562695
      Plectin; Plectin repeat
      pfam09728
      Location:15241839
      Taxilin; Myosin-like coiled-coil protein
      pfam10174
      Location:10321681
      Cast; RIM-binding protein of the cytomatrix active zone
      pfam12761
      Location:15141662
      End3; Actin cytoskeleton-regulatory complex protein END3
      cd16269
      Location:13821393
      GBP_C; coiled coil [structural motif]
      cl02488
      Location:197373
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:13181412
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl24005
      Location:12761349
      DUF2570; Protein of unknown function (DUF2570)
    2. XM_017587717.1XP_017443206.1  desmoplakin isoform X2

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