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    Rack1 receptor for activated C kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 14694, updated on 17-Feb-2018
    Official Symbol
    Rack1provided by MGI
    Official Full Name
    receptor for activated C kinase 1provided by MGI
    Primary source
    MGI:MGI:101849
    See related
    Ensembl:ENSMUSG00000020372 Vega:OTTMUSG00000005526
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p205; Gnb2l1; GB-like; AL033335; Gnb2-rs1
    Expression
    Ubiquitous expression in ovary adult (RPKM 1476.2), thymus adult (RPKM 1056.2) and 28 other tissues See more
    Orthologs
    Location:
    11; 11 B1.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (48800360..48806241)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (48613862..48619743)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 pseudogene Neighboring gene predicted gene, 36109 Neighboring gene small nucleolar RNA, C/D box 96A Neighboring gene small nucleolar RNA, C/D box 95 Neighboring gene tripartite motif-containing 41 Neighboring gene nuclear encoded tRNA valine 7 (anticodon CAC)

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    cadherin binding ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin binding ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine-type endopeptidase activator activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    ion channel inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase C binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    signal transducer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    gastrulation IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of hydrogen peroxide-induced neuron death IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of hydrogen peroxide-induced neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of Golgi to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cAMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cyclic-nucleotide phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of growth IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    rescue of stalled ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    IRE1-RACK1-PP2A complex ISO
    Inferred from Sequence Orthology
    more info
     
    cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    phagocytic cup ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    ribosome IEA
    Inferred from Electronic Annotation
    more info
     
    small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    receptor of activated protein C kinase 1
    Names
    12-3
    activated protein kinase C receptor
    guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 sequence 1
    guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
    guanine nucleotide binding protein related
    guanine nucleotide binding protein, beta 2, related sequence 1
    guanine nucleotide-binding protein subunit beta-2-like 1
    receptor of activated protein kinase C 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008143.3NP_032169.1  receptor of activated protein C kinase 1

      See identical proteins and their annotated locations for NP_032169.1

      Status: VALIDATED

      Source sequence(s)
      AK017772
      Consensus CDS
      CCDS24585.1
      UniProtKB/Swiss-Prot
      P68040
      Related
      ENSMUSP00000020640.7, OTTMUSP00000043241, ENSMUST00000020640.7, OTTMUST00000012289
      Conserved Domains (2) summary
      cd00200
      Location:7311
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:1861
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      48800360..48806241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 CAST/Ei

    Genomic

    1. NT_187028.1 Reference GRCm38.p4 CAST/Ei

      Range
      240186..246277 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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