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    Plk4 polo-like kinase 4 [ Mus musculus (house mouse) ]

    Gene ID: 20873, updated on 25-May-2017
    Official Symbol
    Plk4provided by MGI
    Official Full Name
    polo-like kinase 4provided by MGI
    Primary source
    MGI:MGI:101783
    See related
    Ensembl:ENSMUSG00000025758 Vega:OTTMUSG00000035882
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sak; Stk18; AI385771; 1700028H20
    Summary
    This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to the nucleolus during G2, to centrosomes during G2/M, and to the cleavage furrow during cytokinesis. It is required for progression through mitosis, cell survival, and embryonic development. The mouse genome contains a pseudogene similar to this gene. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
    Orthologs
    Location:
    3; 3 B
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (40799951..40816883)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (40603873..40620805)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 Neighboring gene heat shock protein 4 like Neighboring gene major facilitator superfamily domain containing 8 Neighboring gene predicted gene 2011 Neighboring gene FUN14 domain containing 2 pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    centriole replication ISO
    Inferred from Sequence Orthology
    more info
     
    de novo centriole assembly involved in multi-ciliated epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of centriole replication ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    trophoblast giant cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    XY body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centriole ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    deuterosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    serine/threonine-protein kinase PLK4
    Names
    PLK-4
    serine/threonine kinase 18
    serine/threonine-protein kinase 18
    serine/threonine-protein kinase Sak
    NP_035625.2
    NP_775261.2
    XP_006500831.1
    XP_006500833.1
    XP_011238270.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011495.2NP_035625.2  serine/threonine-protein kinase PLK4 isoform 1

      See identical proteins and their annotated locations for NP_035625.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC146980, AK137471, BC051483
      Consensus CDS
      CCDS17328.1
      UniProtKB/Swiss-Prot
      Q64702
      Related
      ENSMUSP00000026858.5, OTTMUSP00000050763, ENSMUST00000026858.10, OTTMUST00000092020
      Conserved Domains (5) summary
      smart00220
      Location:12265
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13114
      Location:548659
      POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd13115
      Location:660768
      POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd13116
      Location:839918
      POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd14186
      Location:10265
      STKc_PLK4; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4
    2. NM_173169.2NP_775261.2  serine/threonine-protein kinase PLK4 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC146980, AK137471, BC051483
      Consensus CDS
      CCDS57210.1
      UniProtKB/Swiss-Prot
      Q64702
      Related
      ENSMUSP00000145277.1, OTTMUSP00000050765, ENSMUST00000203295.2, OTTMUST00000092023
      Conserved Domains (5) summary
      smart00220
      Location:12265
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13114
      Location:548632
      POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd13115
      Location:633741
      POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd13116
      Location:812891
      POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd14186
      Location:10265
      STKc_PLK4; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4

    RNA

    1. NR_045576.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of an exon compared to variant 1, that causes a frameshift. The resulting transcript has a short orf with a strong Kozak signal that renders this transcript a nonsense-mediated mRNA decay (NMD) candidate. Therefore, this transcript is thought to be non-protein coding.
      Source sequence(s)
      AC146980, AK164465, BC051483
      Related
      ENSMUST00000203895.2, OTTMUST00000133366

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      40799951..40816883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500770.3XP_006500833.1  serine/threonine-protein kinase PLK4 isoform X3

      Conserved Domains (3) summary
      cd13114
      Location:122233
      POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd13115
      Location:234342
      POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd13116
      Location:413492
      POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
    2. XM_006500768.2XP_006500831.1  serine/threonine-protein kinase PLK4 isoform X1

      See identical proteins and their annotated locations for XP_006500831.1

      Conserved Domains (5) summary
      smart00220
      Location:13266
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13114
      Location:549660
      POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd13115
      Location:661769
      POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd13116
      Location:840919
      POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd14186
      Location:11266
      STKc_PLK4; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4
    3. XM_011239968.1XP_011238270.1  serine/threonine-protein kinase PLK4 isoform X2

      Conserved Domains (5) summary
      smart00220
      Location:13266
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13114
      Location:549647
      POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd13116
      Location:790869
      POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd14186
      Location:11266
      STKc_PLK4; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4
      cl02916
      Location:642719
      POLO_box; Polo-box domain (PBD), a C-terminal tandemly repeated region of polo-like kinases
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