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    Chrm1 cholinergic receptor, muscarinic 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25229, updated on 21-Jan-2018
    Official Symbol
    Chrm1provided by RGD
    Official Full Name
    cholinergic receptor, muscarinic 1provided by RGD
    Primary source
    RGD:2342
    See related
    Ensembl:ENSRNOG00000018385
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    plays a role in acetylcholine receptor signaling and neuromuscular synaptic transmission [RGD, Feb 2006]
    Expression
    Restricted expression toward (RPKM 73.8) See more
    Orthologs
    Location:
    1q43
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (224869087..224885101)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (231806335..231822359)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 8 Neighboring gene uncharacterized LOC102550957 Neighboring gene solute carrier family 22 member 6 Neighboring gene solute carrier family 3 member 2 Neighboring gene uncharacterized LOC100912041

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    G-protein coupled acetylcholine receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G-protein coupled acetylcholine receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    drug binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    G-protein coupled acetylcholine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cognition IEA
    Inferred from Electronic Annotation
    more info
     
    neuromuscular synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of intracellular protein transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ion transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of locomotion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of locomotion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of vascular smooth muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    saliva secretion IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic transmission, cholinergic IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    asymmetric synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    synapse TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    muscarinic acetylcholine receptor M1
    Names
    Cholinergic receptor, muscarin 1
    m1 muscarinic acetylcholine receptor protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080773.1NP_542951.1  muscarinic acetylcholine receptor M1

      See identical proteins and their annotated locations for NP_542951.1

      Status: PROVISIONAL

      Source sequence(s)
      M16406
      UniProtKB/Swiss-Prot
      P08482
      Related
      ENSRNOP00000024785.2, ENSRNOT00000024785.4
      Conserved Domains (2) summary
      pfam00001
      Location:42418
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:25166
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      224869087..224885101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230974.3XP_006231036.1  muscarinic acetylcholine receptor M1 isoform X1

      See identical proteins and their annotated locations for XP_006231036.1

      UniProtKB/Swiss-Prot
      P08482
      Conserved Domains (2) summary
      pfam00001
      Location:42418
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:25166
      7tm_4; Olfactory receptor
    2. XM_008760215.2XP_008758437.1  muscarinic acetylcholine receptor M1 isoform X1

      See identical proteins and their annotated locations for XP_008758437.1

      UniProtKB/Swiss-Prot
      P08482
      Conserved Domains (2) summary
      pfam00001
      Location:42418
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:25166
      7tm_4; Olfactory receptor

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      203093639..203095021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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