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    mdfA multidrug efflux system protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945448, updated on 25-Apr-2017
    Gene symbol
    mdfA
    Gene description
    multidrug efflux system protein
    Primary source
    EcoGene:EG13696
    Locus tag
    b0842
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia
    Also known as
    cmlA; cmr; ECK0832; JW0826
    Summary
    Major Facilitator Superfamily (MFS). [More information is available at EcoGene: EG13696]. The MdfA protein, also known as Cmr, is a multidrug efflux protein belonging to the major facilitator superfamily (MFS) . [More information is available at EcoCyc: G6440].
    Sequence:
    NC_000913.3 (883673..884905)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene deoxyribose-5-phosphate-inducible deoxyribose operon transcriptional repressor; repressor of nupG and tsx Neighboring gene undecaprenyl pyrophosphate phosphatase Neighboring gene uncharacterized protein Neighboring gene 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase; pyrimidine phosphatase; riboflavin synthesis Neighboring gene putative drug efflux MFS transporter, inner membrane protein

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    drug transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    drug transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    drug:proton antiporter activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    potassium:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    potassium:proton antiporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sodium:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sodium:proton antiporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    drug transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    drug transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cellular pH IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to antibiotic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sodium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Names
    multidrug efflux system protein
    NP_415363.1
    • proton motive force efflux pump

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      883673..884905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415363.1 multidrug efflux system protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415363.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P0AEY8
      Conserved Domains (2) summary
      cd06174
      Location:20399
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      PRK15402
      Location:7410
      PRK15402; multidrug efflux system translocase MdfA; Provisional
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