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    TUBG1 tubulin gamma 1 [ Homo sapiens (human) ]

    Gene ID: 7283, updated on 5-Nov-2017
    Official Symbol
    TUBG1provided by HGNC
    Official Full Name
    tubulin gamma 1provided by HGNC
    Primary source
    HGNC:HGNC:12417
    See related
    Ensembl:ENSG00000131462 MIM:191135; Vega:OTTHUMG00000180277
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TUBG; GCP-1; CDCBM4; TUBGCP1
    Summary
    This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7. [provided by RefSeq, Jan 2009]
    Expression
    Broad expression in testis (RPKM 90.1), bone marrow (RPKM 18.5) and 23 other tissues See more
    Orthologs
    Location:
    17q21.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (42609340..42615238)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40761358..40767256)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Coenzyme A synthase Neighboring gene MLX, MAX dimerization protein Neighboring gene PSMC3 interacting protein Neighboring gene reticulophagy regulator family member 3 Neighboring gene ATP synthase membrane subunit g pseudogene 7 Neighboring gene high mobility group box 3 pseudogene 27

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env Treatment of cells with actin-depolymerizing agents or tubulin polymerization inhibitors largely reduces the percentage of cells with capped HIV-1 Gag and Env, indicating an intact actin and tubulin cytoskeleton is required for efficient assembly of HIV-1 PubMed
    Pr55(Gag) gag Treatment of cells with actin-depolymerizing agents or tubulin polymerization inhibitors largely reduces the percentage of cells with capped HIV-1 Gag and Env, indicating an intact actin and tubulin cytoskeleton is required for efficient assembly of HIV-1 PubMed
    Tat tat HIV-1 Tat K29A, K50R, and K51R lysine mutations downregulate the proportion of soluble tubulin in cells, while the majority of other lysine mutations upregulate the percentage of soluble tubulin compared with the wild-type PubMed
    tat HIV-1 Tat (specifically, amino acids 38-72), enhances tubulin polymerization and triggers the mitochondrial pathway to induce T cell apoptosis as shown in vitro by the release of cytochrome c from isolated mitochondria PubMed
    Vpr vpr HIV-1 Vpr-expressing HeLa cells stained with centriole markers pericentrin, gamma-tubulin, and Cen2 contain multiple pairs of centrioles scattered in the perinuclear region, indicating Vpr causes the accumulation of multiple centrosome-like structures PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    G2/M transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    ciliary basal body-plasma membrane docking TAS
    Traceable Author Statement
    more info
     
    cytoplasmic microtubule organization IEA
    Inferred from Electronic Annotation
    more info
     
    meiotic spindle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    microtubule cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    microtubule nucleation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of G2/M transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    apical part of cell IEA
    Inferred from Electronic Annotation
    more info
     
    cell leading edge IEA
    Inferred from Electronic Annotation
    more info
     
    centriole IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
     
    condensed nuclear chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasmic microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    gamma-tubulin complex TAS
    Traceable Author Statement
    more info
    PubMed 
    non-motile cilium IEA
    Inferred from Electronic Annotation
    more info
     
    pericentriolar material IEA
    Inferred from Electronic Annotation
    more info
     
    polar microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    tubulin gamma-1 chain
    Names
    gamma-tubulin complex component 1
    tubulin, gamma polypeptide

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033886.1 RefSeqGene

      Range
      5001..10899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001070.4NP_001061.2  tubulin gamma-1 chain

      See identical proteins and their annotated locations for NP_001061.2

      Status: REVIEWED

      Source sequence(s)
      AC067852, BC000619, BG167819, DB028144
      Consensus CDS
      CCDS11433.1
      UniProtKB/Swiss-Prot
      P23258
      Related
      ENSP00000251413.2, OTTHUMP00000263808, ENST00000251413.7, OTTHUMT00000450548
      Conserved Domains (1) summary
      cd02188
      Location:3435
      gamma_tubulin; The gamma-tubulin family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      42609340..42615238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      40997122..41003018
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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