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    Proc protein C [ Mus musculus (house mouse) ]

    Gene ID: 19123, updated on 8-Dec-2016
    Official Symbol
    Procprovided by MGI
    Official Full Name
    protein Cprovided by MGI
    Primary source
    MGI:MGI:97771
    See related
    Ensembl:ENSMUSG00000024386
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PC
    Summary
    This gene encodes the vitamin K-dependent protein C, which plays a vital role in the anticoagulation pathway. The encoded protein undergoes proteolytic processing including activation by thrombin-thrombomodulin complex to form the anticoagulant serine protease that degrades activated coagulation factors. A complete lack of the encoded protein in mice results in severe perinatal consumptive coagulopathy in the brain and liver, resulting in death within 24 hours after birth. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate the mature protein. [provided by RefSeq, Sep 2015]
    Orthologs
    Location:
    18; 18 B1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (32123126..32139570, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (32282780..32299224, complement)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 35010 Neighboring gene IWS1, SUPT6 interacting protein Neighboring gene eukaryotic translation initiation factor pseudogene Neighboring gene predicted gene, 26717 Neighboring gene predicted gene, 34806

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oligopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein self-association ISO
    Inferred from Sequence Orthology
    more info
     
    serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    blood coagulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hemostasis IEA
    Inferred from Electronic Annotation
    more info
     
    liver development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of blood coagulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of circulating fibrinogen levels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    vitamin K-dependent protein C
    Names
    anticoagulant protein C
    autoprothrombin IIA
    blood coagulation factor XIV
    inactivator of coagulation factors Va, VIII
    NP_001036232.1
    NP_001036233.2
    NP_001300867.1
    NP_032960.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042767.3NP_001036232.1  vitamin K-dependent protein C isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001036232.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses an in-frame downstream start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AC126686, AC127347, BX639472, CJ237265, DV662175
      Consensus CDS
      CCDS29116.1
      UniProtKB/Swiss-Prot
      P33587
      Related
      ENSMUSP00000132226, ENSMUST00000171765
      Conserved Domains (5) summary
      smart00020
      Location:211444
      Tryp_SPc; Trypsin-like serine protease
      smart00069
      Location:2686
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:87131
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00190
      Location:212446
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam14670
      Location:139174
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    2. NM_001042768.3NP_001036233.2  vitamin K-dependent protein C isoform 3 precursor

      See identical proteins and their annotated locations for NP_001036233.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct and shorter N-terminus, compared to isoform 1. This isoform (3) may undergo proteolytic processing similar to isoform 2.
      Source sequence(s)
      AC127347, BX639472, BY086829, BY788141, CJ237265, DV662175
      Conserved Domains (5) summary
      smart00020
      Location:220453
      Tryp_SPc; Trypsin-like serine protease
      smart00069
      Location:3595
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:96140
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00190
      Location:221455
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam14670
      Location:148183
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    3. NM_001313938.1NP_001300867.1  vitamin K-dependent protein C isoform 2 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC127347, BX639472, BY082597, BY086829, CJ237265, DV662175
      Consensus CDS
      CCDS29116.1
      UniProtKB/Swiss-Prot
      P33587
      Conserved Domains (5) summary
      smart00020
      Location:211444
      Tryp_SPc; Trypsin-like serine protease
      smart00069
      Location:2686
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:87131
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00190
      Location:212446
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam14670
      Location:139174
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    4. NM_008934.4NP_032960.3  vitamin K-dependent protein C isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). This isoform (1) may undergo proteolytic processing similar to isoform 2.
      Source sequence(s)
      AC127347, BX639472, BY086829, CJ237265, DV662175
      Conserved Domains (5) summary
      smart00020
      Location:232465
      Tryp_SPc; Trypsin-like serine protease
      smart00069
      Location:47107
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:108152
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00190
      Location:233467
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam14670
      Location:160195
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      32123126..32139570 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246857.2XP_011245159.1  

      See identical proteins and their annotated locations for XP_011245159.1

      UniProtKB/Swiss-Prot
      P33587
      Conserved Domains (5) summary
      smart00020
      Location:211444
      Tryp_SPc; Trypsin-like serine protease
      smart00069
      Location:2686
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:87131
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00190
      Location:212446
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam14670
      Location:139174
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    2. XM_006525722.3XP_006525785.1  

      See identical proteins and their annotated locations for XP_006525785.1

      Conserved Domains (5) summary
      smart00020
      Location:220453
      Tryp_SPc; Trypsin-like serine protease
      smart00069
      Location:3595
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:96140
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00190
      Location:221455
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam14670
      Location:148183
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    3. XM_006525721.3XP_006525784.1  

      Conserved Domains (5) summary
      smart00020
      Location:235468
      Tryp_SPc; Trypsin-like serine protease
      smart00069
      Location:50110
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:111155
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00190
      Location:236470
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam14670
      Location:163198
      FXa_inhibition; Coagulation Factor Xa inhibitory site
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