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    ATF5 activating transcription factor 5 [ Homo sapiens (human) ]

    Gene ID: 22809, updated on 15-May-2017
    Official Symbol
    ATF5provided by HGNC
    Official Full Name
    activating transcription factor 5provided by HGNC
    Primary source
    HGNC:HGNC:790
    See related
    Ensembl:ENSG00000169136 MIM:606398; Vega:OTTHUMG00000183065
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATFX; HMFN0395
    Orthologs
    Location:
    19q13.33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (49928702..49933936)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50431959..50437193)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 17 Neighboring gene uncharacterized LOC107985277 Neighboring gene microRNA 4750 Neighboring gene interleukin 4 induced 1 Neighboring gene nucleoporin 62 Neighboring gene microRNA 4751 Neighboring gene sialic acid binding Ig like lectin 11 Neighboring gene sialic acid binding Ig like lectin 16 (gene/pseudogene)

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ34666

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA polymerase II regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcription corepressor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcription regulatory region DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IC
    Inferred by Curator
    more info
     
    tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cerebellar granule cell precursor proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    circadian rhythm IEA
    Inferred from Electronic Annotation
    more info
     
    fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell cycle G2/M phase transition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    olfactory bulb interneuron development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of centrosome cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    cyclic AMP-dependent transcription factor ATF-5
    Names
    cAMP-dependent transcription factor ATF-5
    transcription factor ATFx

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193646.1NP_001180575.1  cyclic AMP-dependent transcription factor ATF-5

      See identical proteins and their annotated locations for NP_001180575.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as alpha) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AB021663, AB073613, BF528888, BP378116, BU730542
      Consensus CDS
      CCDS12789.1
      UniProtKB/Swiss-Prot
      Q9Y2D1
      UniProtKB/TrEMBL
      A0A024QZG3
      Related
      ENSP00000396954.1, OTTHUMP00000270773, ENST00000423777.6, OTTHUMT00000464915
      Conserved Domains (1) summary
      cd14692
      Location:209271
      bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain
    2. NM_001290746.1NP_001277675.1  cyclic AMP-dependent transcription factor ATF-5

      See identical proteins and their annotated locations for NP_001277675.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as beta) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AB021663, AB073613, AC011452, BU730542, HY011917
      Consensus CDS
      CCDS12789.1
      UniProtKB/Swiss-Prot
      Q9Y2D1
      UniProtKB/TrEMBL
      A0A024QZG3
      Conserved Domains (1) summary
      cd14692
      Location:209271
      bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain
    3. NM_012068.5NP_036200.2  cyclic AMP-dependent transcription factor ATF-5

      See identical proteins and their annotated locations for NP_036200.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AB021663, BU187153, BU730542, DA251296
      Consensus CDS
      CCDS12789.1
      UniProtKB/Swiss-Prot
      Q9Y2D1
      UniProtKB/TrEMBL
      A0A024QZG3
      Related
      ENSP00000470633.1, OTTHUMP00000270799, ENST00000595125.5, OTTHUMT00000464972
      Conserved Domains (1) summary
      cd14692
      Location:209271
      bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      49928702..49933936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526629.2XP_011524931.1  cyclic AMP-dependent transcription factor ATF-5 isoform X1

      See identical proteins and their annotated locations for XP_011524931.1

      UniProtKB/Swiss-Prot
      Q9Y2D1
      UniProtKB/TrEMBL
      A0A024QZG3
      Conserved Domains (1) summary
      cd14692
      Location:209271
      bZIP_ATF4; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      50433787..50439041
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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