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    SCRIB scribbled planar cell polarity protein [ Homo sapiens (human) ]

    Gene ID: 23513, updated on 15-Aug-2017
    Official Symbol
    SCRIBprovided by HGNC
    Official Full Name
    scribbled planar cell polarity proteinprovided by HGNC
    Primary source
    HGNC:HGNC:30377
    See related
    Ensembl:ENSG00000180900 MIM:607733; Vega:OTTHUMG00000165154
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRIB1; SCRB1; SCRIB1; Vartul
    Summary
    This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
    Orthologs
    Location:
    8q24.3
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 8 NC_000008.11 (143790920..143815379, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144873090..144897890, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene chromosome 12 open reading frame 49 pseudogene Neighboring gene IQ motif and ankyrin repeat containing 1 Neighboring gene microRNA 937 Neighboring gene poly(U) binding splicing factor 60 Neighboring gene uncharacterized LOC107986985 Neighboring gene nuclear receptor binding protein 2 Neighboring gene microRNA 6845

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    NHGRI GWA Catalog
    • Asymmetric localization of PCP proteins, organism-specific biosystem (from REACTOME)
      Asymmetric localization of PCP proteins, organism-specific biosystemOne of the hallmarks of the Planar Cell Polarity pathway is the asymmetric distribution of proteins on opposite membranes of a single cell. In Drosophila, Stbm and Pk (homologues to the human VANGL1/...
    • Beta-catenin independent WNT signaling, organism-specific biosystem (from REACTOME)
      Beta-catenin independent WNT signaling, organism-specific biosystemHumans and mice have 19 identified WNT proteins that were originally classified as either 'canonical' or 'non-canonical' depending upon whether they were able to transform the mouse mammary epithelia...
    • Hippo signaling pathway, organism-specific biosystem (from KEGG)
      Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Hippo signaling pathway, conserved biosystem (from KEGG)
      Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Human Thyroid Stimulating Hormone (TSH) signaling pathway, organism-specific biosystem (from WikiPathways)
      Human Thyroid Stimulating Hormone (TSH) signaling pathway, organism-specific biosystemHuman thyroid stimulating hormone (TSH) is a glycoprotein hormone secreted from the anterior pituitary lobe, which plays an important physiological role in regulation of the hypothalamus-pituitary-th...
    • PCP/CE pathway, organism-specific biosystem (from REACTOME)
      PCP/CE pathway, organism-specific biosystemThe planar cell polarity (PCP) pathway controls the establishment of polarity within the plane of a sheet of cells. PCP was initially characterized in Drosophila, where it controls the arrangement o...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Wnt, organism-specific biosystem (from REACTOME)
      Signaling by Wnt, organism-specific biosystemWNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Sai...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
      Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cadherin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    guanylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ionotropic glutamate receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    GDP metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    GMP metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    activation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic process involved in morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    astrocyte cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    asymmetric protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    auditory receptor cell stereocilium organization IEA
    Inferred from Electronic Annotation
    more info
     
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cochlear nucleus development IEA
    Inferred from Electronic Annotation
    more info
     
    establishment of apical/basal cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment or maintenance of epithelial cell apical/basal polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mammary gland duct morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neurotransmitter receptor transport postsynaptic membrane to endosome IEA
    Inferred from Electronic Annotation
    more info
     
    neurotransmitter receptor transport, endosome to postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    positive chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of receptor recycling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to adherens junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    receptor clustering IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    receptor localization to synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    synaptic vesicle endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle targeting IEA
    Inferred from Electronic Annotation
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Scrib-APC-beta-catenin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell junction IDA
    Inferred from Direct Assay
    more info
     
    colocalizes_with cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell contact zone IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with ionotropic glutamate receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath abaxonal region IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    protein scribble homolog
    Names
    scribbled homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030583.1 RefSeqGene

      Range
      5001..29460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_015356.4NP_056171.3  protein scribble homolog isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AF240677, AI829609, AY062238, BC014632
      Consensus CDS
      CCDS6411.1
      UniProtKB/Swiss-Prot
      Q14160
      UniProtKB/TrEMBL
      A0A0G2JNZ2
      Related
      ENSP00000322938.3, OTTHUMP00000228641, ENST00000320476.7, OTTHUMT00000382215
      Conserved Domains (5) summary
      smart00228
      Location:725813
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      COG4886
      Location:39401
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:12232
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd00992
      Location:10021090
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00033
      Location:1437
      LRR_RI; leucine-rich repeat [structural motif]
    2. NM_182706.4NP_874365.3  protein scribble homolog isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AI829609, AY062238, BC009490, BC014632, BC044627
      Consensus CDS
      CCDS6412.1
      UniProtKB/Swiss-Prot
      Q14160
      UniProtKB/TrEMBL
      A0A0G2JPP5, A0PJK8
      Related
      ENSP00000349486.2, OTTHUMP00000228640, ENST00000356994.6, OTTHUMT00000382214
      Conserved Domains (6) summary
      smart00228
      Location:725813
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      COG4886
      Location:39401
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:12232
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd00992
      Location:10021090
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00033
      Location:1437
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16182
      Location:15551593
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p7 Primary Assembly

      Range
      143790920..143815379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p7 ALT_REF_LOCI_1

    Genomic

    1. NT_187571.1 Reference GRCh38.p7 ALT_REF_LOCI_1

      Range
      267967..292426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018919.2 Alternate CHM1_1.1

      Range
      144913332..144937791 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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