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    S100b S100 protein, beta polypeptide, neural [ Mus musculus (house mouse) ]

    Gene ID: 20203, updated on 25-Apr-2017
    Official Symbol
    S100bprovided by MGI
    Official Full Name
    S100 protein, beta polypeptide, neuralprovided by MGI
    Primary source
    MGI:MGI:98217
    See related
    Ensembl:ENSMUSG00000033208 Vega:OTTMUSG00000020277
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bpb; AI850290
    Orthologs
    Location:
    10 C1; 10 38.76 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (76253836..76261319)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (75716581..75724064)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L32 pseudogene Neighboring gene microRNA 678 Neighboring gene protein arginine N-methyltransferase 2 Neighboring gene disco interacting protein 2 homolog A Neighboring gene predicted gene, 40699

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC74317

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RAGE receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    S100 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cellular calcium ion homeostasis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    energy reserve metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of skeletal muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cytokine biosynthetic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of long-term neuronal synaptic plasticity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    protein S100-B
    Names
    S-100 protein beta chain
    S-100 protein subunit beta
    S100 calcium-binding protein B

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009115.3NP_033141.1  protein S100-B

      See identical proteins and their annotated locations for NP_033141.1

      Status: VALIDATED

      Source sequence(s)
      AK135083, AW456919, BC061178, CX205737
      Consensus CDS
      CCDS35943.1
      UniProtKB/Swiss-Prot
      P50114
      UniProtKB/TrEMBL
      Q3UY00
      Related
      ENSMUSP00000047968.7, OTTMUSP00000021974, ENSMUST00000036387.7, OTTMUST00000048129
      Conserved Domains (2) summary
      cd05027
      Location:289
      S-100B; S-100B: S-100B domain found in proteins similar to S100B. S100B is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...
      pfam13499
      Location:2778
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      76253836..76261319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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