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    Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24296, updated on 8-Oct-2017
    Official Symbol
    Cyp1a1provided by RGD
    Official Full Name
    cytochrome P450, family 1, subfamily a, polypeptide 1provided by RGD
    Primary source
    RGD:2458
    See related
    Ensembl:ENSRNOG00000019500
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AHH; AHRR; CP11; CYP1; Cyp45c; P1-450; P450-C; P450DX; Cypc45c; P-450MC
    Summary
    monooxygenase that plays a role in dioxin metabolism and detoxification which is 3-methylcholanthrene-inducible [RGD, Feb 2006]
    Location:
    8q24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (62472087..62478122)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (62249046..62255081)

    Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene C-terminal Src kinase Neighboring gene cytochrome P450, family 1, subfamily a, polypeptide 2 Neighboring gene enhancer of mRNA decapping 3 Neighboring gene CDC-like kinase 3

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    aromatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    catalytic activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    demethylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    estrogen 16-alpha-hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    estrogen 16-alpha-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    flavonoid 3'-monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    oxidoreductase activity, acting on diphenols and related substances as donors IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    steroid hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vitamin D 24-hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    vitamin D 24-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    9-cis-retinoic acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    amine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    amine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    camera-type eye development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cell proliferation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to copper ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    coumarin metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    demethylation IEA
    Inferred from Electronic Annotation
    more info
     
    developmental process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    dibenzo-p-dioxin catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dibenzo-p-dioxin catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dibenzo-p-dioxin metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT dibenzo-p-dioxin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    digestive tract development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    drug metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    drug metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    flavonoid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hepatocyte differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    heterocycle metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    hydrogen peroxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    hydrogen peroxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    insecticide metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid hydroxylation IEA
    Inferred from Electronic Annotation
    more info
     
    lipid hydroxylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    liver development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    maternal process involved in parturition IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    porphyrin-containing compound metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to antibiotic IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to arsenic-containing substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to food IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to herbicide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hyperoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to immobilization stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to iron(III) ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to nematode IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to toxic substance ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to virus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to vitamin A IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to wounding IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    toxin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    cytochrome P450 1A1
    Names
    CYPIA1
    P450MT2
    P450form6
    aryl hydrocarbon hydroxylase
    cytochrome P1-450
    cytochrome P450 subfamily I (aromatic compound-inducible) member A1 (C6 form c) (C6 form c)
    cytochrome P450, 1a1
    cytochrome P450, subfamily I (aromatic compound-inducible), member A1 (C6, form c) (C6, form c)
    cytochrome P450-C
    cytochrome P450MT2
    dioxin-inducible
    flavoprotein-linked monooxygenase
    microsomal monooxygenase
    xenobiotic monooxygenase
    NP_036672.2
    XP_006243212.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012540.2NP_036672.2  cytochrome P450 1A1

      See identical proteins and their annotated locations for NP_036672.2

      Status: PROVISIONAL

      Source sequence(s)
      X00469
      UniProtKB/Swiss-Prot
      P00185
      Related
      ENSRNOP00000026473.2, ENSRNOT00000026473.4
      Conserved Domains (1) summary
      pfam00067
      Location:44496
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

      Range
      62472087..62478122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243150.2XP_006243212.1  cytochrome P450 1A1 isoform X1

      See identical proteins and their annotated locations for XP_006243212.1

      UniProtKB/Swiss-Prot
      P00185
      Conserved Domains (1) summary
      pfam00067
      Location:44496
      p450; Cytochrome P450

    Alternate Rn_Celera

    Genomic

    1. AC_000076.1 Alternate Rn_Celera

      Range
      57561801..57567827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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