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    Ctla4 cytotoxic T-lymphocyte-associated protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 63835, updated on 11-Jun-2017
    Official Symbol
    Ctla4provided by RGD
    Official Full Name
    cytotoxic T-lymphocyte-associated protein 4provided by RGD
    Primary source
    RGD:61975
    See related
    Ensembl:ENSRNOG00000054129 Vega:OTTRNOG00000000097
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cd152; CTLA-4; sCTLA4
    Summary
    immunoregulatory receptor expressed on the surface of T and B lymphocytes [RGD, Feb 2006]
    Orthologs
    Location:
    9q32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (67699397..67706068)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 9 NC_005108.3 (67509236..67515681)

    Chromosome 9 - NC_005108.4Genomic Context describing neighboring genes Neighboring gene Cd28 molecule Neighboring gene uncharacterized LOC108351939 Neighboring gene inducible T-cell co-stimulator Neighboring gene similar to proteasome (prosome, macropain) subunit, alpha type 7

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Autoimmune thyroid disease, organism-specific biosystem (from KEGG)
      Autoimmune thyroid disease, organism-specific biosystemThe classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroidi...
    • Autoimmune thyroid disease, conserved biosystem (from KEGG)
      Autoimmune thyroid disease, conserved biosystemThe classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroidi...
    • CTLA4 inhibitory signaling, organism-specific biosystem (from REACTOME)
      CTLA4 inhibitory signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
      Costimulation by the CD28 family, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
      Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Rheumatoid arthritis, conserved biosystem (from KEGG)
      Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of regulatory T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of regulatory T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular_component ND
    No biological Data available
    more info
     
    clathrin-coated endocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    clathrin-coated endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex involved in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    protein complex involved in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    cytotoxic T-lymphocyte protein 4
    Names
    CD152 antigen
    soluble form
    transmembrane form

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031674.1NP_113862.1  cytotoxic T-lymphocyte protein 4 precursor

      See identical proteins and their annotated locations for NP_113862.1

      Status: PROVISIONAL

      Source sequence(s)
      U37121
      UniProtKB/TrEMBL
      Q62859
      Related
      ENSRNOP00000073071.1, OTTRNOP00000001599, ENSRNOT00000091237.1, OTTRNOT00000000101
      Conserved Domains (2) summary
      cd05721
      Location:39152
      IgV_CTLA-4; Immunoglobulin (Ig) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
      smart00410
      Location:43132
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005108.4 Reference Rnor_6.0 Primary Assembly

      Range
      67699397..67706068
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245036.3XP_006245098.1  cytotoxic T-lymphocyte protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006245098.1

      UniProtKB/TrEMBL
      G3V7D2
      Related
      ENSRNOP00000069885.1, OTTRNOP00000000033, ENSRNOT00000088183.1, OTTRNOT00000000102
      Conserved Domains (2) summary
      cd05721
      Location:39152
      IgV_CTLA-4; Immunoglobulin (Ig) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
      smart00410
      Location:43132
      IG_like; Immunoglobulin like

    Alternate Rn_Celera

    Genomic

    1. AC_000077.1 Alternate Rn_Celera

      Range
      59742231..59747758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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