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    Btk Bruton tyrosine kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367901, updated on 22-Apr-2017
    Official Symbol
    Btkprovided by RGD
    Official Full Name
    Bruton tyrosine kinaseprovided by RGD
    Primary source
    RGD:1359683
    See related
    Ensembl:ENSRNOG00000052407
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    Location:
    Xq32
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (105360922..105390580, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) X NC_005120.3 (105250666..105279934, complement)

    Chromosome X - NC_005120.4Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 7-like Neighboring gene translocase of inner mitochondrial membrane 8 homolog A1 (yeast) Neighboring gene ribosomal protein L36a Neighboring gene galactosidase, alpha

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-3,4,5-trisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    B cell affinity maturation IEA
    Inferred from Electronic Annotation
    more info
     
    B cell affinity maturation ISO
    Inferred from Sequence Orthology
    more info
     
    I-kappaB kinase/NF-kappaB signaling IEA
    Inferred from Electronic Annotation
    more info
     
    I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell maturation IEA
    Inferred from Electronic Annotation
    more info
     
    cell maturation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to interleukin-7 IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to interleukin-7 ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to molecule of fungal origin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histamine secretion by mast cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-tyrosine autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of type I hypersensitivity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of type III hypersensitivity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to organic substance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mast cell granule IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    tyrosine-protein kinase BTK
    Names
    Bruton agammaglobulinemia tyrosine kinase
    NP_001007799.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007798.1NP_001007799.1  tyrosine-protein kinase BTK

      See identical proteins and their annotated locations for NP_001007799.1

      Status: PROVISIONAL

      Source sequence(s)
      AY787790
      UniProtKB/TrEMBL
      Q5S255
      Related
      ENSRNOP00000071684.1, ENSRNOT00000077547.1
      Conserved Domains (6) summary
      cd05113
      Location:398653
      PTKc_Btk_Bmx; Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome
      cd10397
      Location:275379
      SH2_Tec_Btk; Src homology 2 (SH2) domain found in Tec protein, Bruton's tyrosine kinase (Btk)
      cd11906
      Location:218272
      SH3_BTK; Src Homology 3 domain of Bruton's tyrosine kinase
      cd01238
      Location:6167
      PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
      pfam00169
      Location:4134
      PH; PH domain
      pfam07714
      Location:403652
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005120.4 Reference Rnor_6.0 Primary Assembly

      Range
      105360922..105390580 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000089.1 Alternate Rn_Celera

      Range
      98764036..98794122 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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