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    DCUN1D1 defective in cullin neddylation 1 domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 54165, updated on 6-Aug-2017
    Official Symbol
    DCUN1D1provided by HGNC
    Official Full Name
    defective in cullin neddylation 1 domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:18184
    See related
    Ensembl:ENSG00000043093 MIM:605905; Vega:OTTHUMG00000158314
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RP42; SCRO; Tes3; DCNL1; SCCRO; DCUN1L1
    Orthologs
    Location:
    3q26.33
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (182938158..182986364, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (182660153..182703731, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374245 Neighboring gene ATPase phospholipid transporting 11B (putative) Neighboring gene eukaryotic translation initiation factor 3 subunit E pseudogene 4 Neighboring gene chromosome 9 open reading frame 85 pseudogene Neighboring gene uncharacterized LOC105374246 Neighboring gene uncharacterized LOC107986159 Neighboring gene methylcrotonoyl-CoA carboxylase 1 Neighboring gene uncharacterized LOC105374247

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ubiquitin-like protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    positive regulation of ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    post-translational protein modification TAS
    Traceable Author Statement
    more info
     
    protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    DCN1-like protein 1
    Names
    DCN1, defective in cullin neddylation 1, domain containing 1
    DCUN1 domain-containing protein 1
    RP42 homolog
    defective in cullin neddylation protein 1-like protein 1
    squamous cell carcinoma-related oncogene

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308101.1NP_001295030.1  DCN1-like protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001295030.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate 5' exon, contains an alternate 5' terminal exon, and uses a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC092953, AF292100, AK025764, AW103206, BC013163, BI828039, BU620603, HY052047
      Consensus CDS
      CCDS77862.1
      UniProtKB/Swiss-Prot
      Q96GG9
      UniProtKB/TrEMBL
      C9JVE2
      Related
      ENSP00000419359.1, OTTHUMP00000212784, ENST00000469954.5, OTTHUMT00000350659
      Conserved Domains (2) summary
      pfam03556
      Location:121232
      Cullin_binding; Cullin binding
      cl21463
      Location:136
      UBA_like_SF; UBA domain-like superfamily
    2. NM_020640.3NP_065691.2  DCN1-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_065691.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC092953, AF292100, AK025764, AK297328, AW103206, BC013163, BU620603, HY031019
      Consensus CDS
      CCDS3240.1
      UniProtKB/Swiss-Prot
      Q96GG9
      UniProtKB/TrEMBL
      B4DM76
      Related
      ENSP00000292782.4, OTTHUMP00000212783, ENST00000292782.8, OTTHUMT00000350658
      Conserved Domains (2) summary
      pfam03556
      Location:136247
      Cullin_binding; Cullin binding
      cl21463
      Location:151
      UBA_like_SF; UBA domain-like superfamily

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

      Range
      182938158..182986364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512915.2XP_011511217.1  DCN1-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011511217.1

      Conserved Domains (2) summary
      pfam03556
      Location:121219
      Cullin_binding; Cullin binding
      cl21463
      Location:136
      UBA_like_SF; UBA domain-like superfamily
    2. XM_011512916.2XP_011511218.1  DCN1-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011511218.1

      Conserved Domains (2) summary
      pfam03556
      Location:121219
      Cullin_binding; Cullin binding
      cl21463
      Location:136
      UBA_like_SF; UBA domain-like superfamily
    3. XM_011512914.1XP_011511216.1  DCN1-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011511216.1

      Conserved Domains (2) summary
      pfam03556
      Location:121219
      Cullin_binding; Cullin binding
      cl21463
      Location:136
      UBA_like_SF; UBA domain-like superfamily
    4. XM_011512912.1XP_011511214.1  DCN1-like protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011511214.1

      Conserved Domains (2) summary
      pfam03556
      Location:136234
      Cullin_binding; Cullin binding
      cl21463
      Location:151
      UBA_like_SF; UBA domain-like superfamily
    5. XM_017006634.1XP_016862123.1  DCN1-like protein 1 isoform X1

      Conserved Domains (2) summary
      pfam03556
      Location:121219
      Cullin_binding; Cullin binding
      cl21463
      Location:136
      UBA_like_SF; UBA domain-like superfamily
    6. XM_017006633.1XP_016862122.1  DCN1-like protein 1 isoform X1

      Conserved Domains (2) summary
      pfam03556
      Location:121219
      Cullin_binding; Cullin binding
      cl21463
      Location:136
      UBA_like_SF; UBA domain-like superfamily
    7. XM_017006635.1XP_016862124.1  DCN1-like protein 1 isoform X3

      UniProtKB/TrEMBL
      C9JVE2
      Related
      ENSP00000488427.1, ENST00000632685.1
      Conserved Domains (2) summary
      pfam03556
      Location:121232
      Cullin_binding; Cullin binding
      cl21463
      Location:136
      UBA_like_SF; UBA domain-like superfamily

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      182618852..182666631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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