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    Itgb5 integrin beta 5 [ Mus musculus (house mouse) ]

    Gene ID: 16419, updated on 23-May-2018
    Official Symbol
    Itgb5provided by MGI
    Official Full Name
    integrin beta 5provided by MGI
    Primary source
    MGI:MGI:96614
    See related
    Ensembl:ENSMUSG00000022817 Vega:OTTMUSG00000028487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    [b]5; [b]-5; [b]5A; [b]5B; beta5; ESTM23; beta-5; AA475909; AI874634
    Expression
    Ubiquitous expression in adrenal adult (RPKM 97.5), ovary adult (RPKM 81.3) and 28 other tissues See more
    Orthologs
    See Itgb5 in Genome Data Viewer
    Location:
    16; 16 B3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (33829665..33949338)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (33829751..33949424)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene mucin 13, epithelial transmembrane Neighboring gene predicted gene, 34967 Neighboring gene uridine monophosphate synthetase Neighboring gene kalirin, RhoGEF kinase Neighboring gene predicted gene, 46566

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    epithelial cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integrin alphav-beta5 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integrin alphav-beta5 complex ISO
    Inferred from Sequence Orthology
    more info
     
    integrin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integrin complex IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145884.1NP_001139356.1  integrin beta-5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001139356.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1.
      Source sequence(s)
      AF022110, BC058246, CJ316400
      Consensus CDS
      CCDS49835.1
      UniProtKB/Swiss-Prot
      O70309
      UniProtKB/TrEMBL
      Q6PE70
      Related
      ENSMUSP00000110680.3, OTTMUSP00000036002, ENSMUST00000115028.9, OTTMUST00000070600
      Conserved Domains (3) summary
      pfam00362
      Location:35463
      Integrin_beta; Integrin, beta chain
      pfam07965
      Location:635718
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:745788
      Integrin_b_cyt; Integrin beta cytoplasmic domain
    2. NM_010580.2NP_034710.2  integrin beta-5 isoform 2 precursor

      See identical proteins and their annotated locations for NP_034710.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate donor splice site at the penultimate coding exon compared to transcript variant 1. This results in a frame-shift, translation termination at a downstream stop codon, and a longer isoform (2) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AF022110, BC058246, CJ316400
      Consensus CDS
      CCDS28135.1
      UniProtKB/Swiss-Prot
      O70309
      UniProtKB/TrEMBL
      G5E8F8, Q6PE70
      Related
      ENSMUSP00000069416.5, OTTMUSP00000036003, ENSMUST00000069345.5, OTTMUST00000070601
      Conserved Domains (3) summary
      pfam00362
      Location:35463
      Integrin_beta; Integrin, beta chain
      pfam07965
      Location:635718
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:745759
      Integrin_b_cyt; Integrin beta cytoplasmic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      33829665..33949338
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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