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    SLC5A6 solute carrier family 5 member 6 [ Homo sapiens (human) ]

    Gene ID: 8884, updated on 22-Apr-2017
    Official Symbol
    SLC5A6provided by HGNC
    Official Full Name
    solute carrier family 5 member 6provided by HGNC
    Primary source
    HGNC:HGNC:11041
    See related
    Ensembl:ENSG00000138074 MIM:604024; Vega:OTTHUMG00000097075
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SMVT
    Orthologs
    Location:
    2p23.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (27199587..27212307, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27422455..27435175, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene proline rich 30 Neighboring gene transcription factor 23 Neighboring gene all-trans retinoic acid induced differentiation factor Neighboring gene carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Neighboring gene solute carrier family 30 member 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 gamma

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Biotin transport and metabolism, organism-specific biosystem (from REACTOME)
      Biotin transport and metabolism, organism-specific biosystemBiotin (Btn) is an essential cofactor in a variety of carboxylation reactions (Zempleni et al. 2009). Humans cannot synthesize Btn but it is abundant in the human diet and can be taken up from the in...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of vitamins and cofactors, organism-specific biosystem (from REACTOME)
      Metabolism of vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, classified according to their solubility, either fat-soluble or water-soluble, that are either not synthesized or synthesized only in limited amount...
    • Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem (from REACTOME)
      Metabolism of water-soluble vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, required in small amounts in the diet. They have distinct biochemical roles, often as coenzymes, and are either not synthesized or synthesized only ...
    • NRF2 pathway, organism-specific biosystem (from WikiPathways)
      NRF2 pathway, organism-specific biosystemNRF2 is part of a group of transcription factors called nuclear receptors. It is activated under oxidative stress conditions and subsequently activates several antioxidative genes and proteins.
    • SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
      SLC-mediated transmembrane transport, organism-specific biosystemProteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the m...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules
    • Transport of vitamins, nucleosides, and related molecules, organism-specific biosystem (from REACTOME)
      Transport of vitamins, nucleosides, and related molecules, organism-specific biosystemThis pathway groups the processes mediated by SLC transporters, by which vitamins and cofactors, as well as nucleosides, nucleotides, nucleobases, and related molecules cross lipid bilayer membranes.
    • Vitamin B5 (pantothenate) metabolism, organism-specific biosystem (from REACTOME)
      Vitamin B5 (pantothenate) metabolism, organism-specific biosystemPanthothenate (vitamin B5) is the precursor of coenzyme A (Robishaw and Neely 1985) and is the prosthetic group of acyl carrier protein (ACP) (Joshi et al. 2003). Its name is derived from the Greek p...
    • Vitamin digestion and absorption, organism-specific biosystem (from KEGG)
      Vitamin digestion and absorption, organism-specific biosystemVitamins are a diverse and chemically unrelated group of organic substances that share a common feature of being essential for normal health and well-being. They catalyze numerous biochemical reactio...
    • Vitamin digestion and absorption, conserved biosystem (from KEGG)
      Vitamin digestion and absorption, conserved biosystemVitamins are a diverse and chemically unrelated group of organic substances that share a common feature of being essential for normal health and well-being. They catalyze numerous biochemical reactio...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    sodium-dependent multivitamin transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    biotin metabolic process TAS
    Traceable Author Statement
    more info
     
    biotin transport IEA
    Inferred from Electronic Annotation
    more info
     
    pantothenate metabolic process TAS
    Traceable Author Statement
    more info
     
    pantothenate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane transport TAS
    Traceable Author Statement
    more info
     
    transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    brush border membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    sodium-dependent multivitamin transporter
    Names
    Na(+)-dependent multivitamin transporter
    Na+-dependent multivitamin transporter
    solute carrier family 5 (sodium-dependent vitamin transporter), member 6
    solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021095.2NP_066918.2  sodium-dependent multivitamin transporter

      See identical proteins and their annotated locations for NP_066918.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AF069307, AF288781, BC012806, DB452476, N30242
      Consensus CDS
      CCDS1740.1
      UniProtKB/Swiss-Prot
      Q9Y289
      UniProtKB/TrEMBL
      Q9HD19
      Related
      ENSP00000310208.3, OTTHUMP00000122593, ENST00000310574.7, OTTHUMT00000214194
      Conserved Domains (1) summary
      cd11504
      Location:24550
      SLC5sbd_SMVT; Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain

    RNA

    1. NR_028323.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has two differences in the presence and absence of alternate segments, compared to variant 1. This variant is represented as non-coding because the use of the 5' most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK027855, BG025980, BI832199, BQ651664, DA958474, DB452476, N30242
      Related
      ENST00000488743.6

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      27199587..27212307 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006712129.1XP_006712192.1  sodium-dependent multivitamin transporter isoform X1

      See identical proteins and their annotated locations for XP_006712192.1

      UniProtKB/Swiss-Prot
      Q9Y289
      Conserved Domains (1) summary
      cd11504
      Location:24550
      SLC5sbd_SMVT; Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain
    2. XM_006712130.1XP_006712193.1  sodium-dependent multivitamin transporter isoform X1

      See identical proteins and their annotated locations for XP_006712193.1

      UniProtKB/Swiss-Prot
      Q9Y289
      Conserved Domains (1) summary
      cd11504
      Location:24550
      SLC5sbd_SMVT; Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain
    3. XM_006712128.1XP_006712191.1  sodium-dependent multivitamin transporter isoform X1

      See identical proteins and their annotated locations for XP_006712191.1

      UniProtKB/Swiss-Prot
      Q9Y289
      Related
      ENSP00000384853.1, OTTHUMP00000201025, ENST00000408041.5, OTTHUMT00000324954
      Conserved Domains (1) summary
      cd11504
      Location:24550
      SLC5sbd_SMVT; Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain
    4. XM_017005216.1XP_016860705.1  sodium-dependent multivitamin transporter isoform X2

    5. XM_011533146.2XP_011531448.1  sodium-dependent multivitamin transporter isoform X3

      Conserved Domains (1) summary
      cl00456
      Location:23327
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RNA

    1. XR_001739022.1 RNA Sequence

    2. XR_001739023.1 RNA Sequence

    3. XR_001739025.1 RNA Sequence

    4. XR_001739024.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      27352374..27365079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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