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    HPSE heparanase [ Homo sapiens (human) ]

    Gene ID: 10855, updated on 22-Apr-2017
    Official Symbol
    HPSEprovided by HGNC
    Official Full Name
    heparanaseprovided by HGNC
    Primary source
    HGNC:HGNC:5164
    See related
    Ensembl:ENSG00000173083 MIM:604724; Vega:OTTHUMG00000130425
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HPA; HPA1; HPR1; HSE1; HPSE1
    Summary
    Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
    Orthologs
    Location:
    4q21.23
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 4 NC_000004.12 (83292461..83335153, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (84213614..84256306, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene placenta specific 8 Neighboring gene coenzyme Q2, polyprenyltransferase Neighboring gene aminomethyltransferase pseudogene Neighboring gene uncharacterized LOC105377313 Neighboring gene chromosome 18 open reading frame 21 pseudogene Neighboring gene helicase, POLQ-like

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Treatment of synaptosomes with heparanase and HIV-1 Tat increases Tat-induced oxidative stress, which indicates the requirement of Tat interaction with neuronal membranes to induce oxidative damage PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    beta-glucuronidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    heparanase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heparanase activity TAS
    Traceable Author Statement
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    syndecan binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region TAS
    Traceable Author Statement
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    lysosomal lumen TAS
    Traceable Author Statement
    more info
     
    lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteinaceous extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    specific granule lumen TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    heparanase
    Names
    endo-glucoronidase
    heparanase-1
    NP_001092010.1
    NP_001159970.1
    NP_001186759.1
    NP_006656.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028037.1 RefSeqGene

      Range
      5001..47693
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001098540.2NP_001092010.1  heparanase isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_001092010.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AC114781, AF144325, AF152376, AW293069
      Consensus CDS
      CCDS3602.1
      UniProtKB/Swiss-Prot
      Q9Y251
      Related
      ENSP00000308107.5, OTTHUMP00000160980, ENST00000311412.9, OTTHUMT00000252813
      Conserved Domains (1) summary
      pfam03662
      Location:171370
      Glyco_hydro_79n; Glycosyl hydrolase family 79, N-terminal domain
    2. NM_001166498.2NP_001159970.1  heparanase isoform 2 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two exons in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the identical N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC114781, AF152376, AW293069, GQ337901
      Consensus CDS
      CCDS54774.1
      UniProtKB/Swiss-Prot
      Q9Y251
      Related
      ENSP00000423265.1, OTTHUMP00000219801, ENST00000512196.5, OTTHUMT00000363969
      Conserved Domains (1) summary
      pfam03662
      Location:171330
      Glyco_hydro_79n; Glycosyl hydrolase family 79, N-terminal domain
    3. NM_001199830.1NP_001186759.1  heparanase isoform 3 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon in the 5' coding region compared to variant 1. The resulting protein (isoform 3) is shorter but has the identical N- and C- termini compared to isoform 1.
      Source sequence(s)
      AC114781, AM419200, AW293069
      Consensus CDS
      CCDS56337.1
      UniProtKB/Swiss-Prot
      Q9Y251
      Related
      ENSP00000421365.1, OTTHUMP00000219799, ENST00000513463.1, OTTHUMT00000363967
      Conserved Domains (1) summary
      pfam03662
      Location:179312
      Glyco_hydro_79n; Glycosyl hydrolase family 79, N-terminal domain
    4. NM_006665.5NP_006656.2  heparanase isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_006656.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AC114781, AF152376, AW293069, BC051321
      Consensus CDS
      CCDS3602.1
      UniProtKB/Swiss-Prot
      Q9Y251
      Related
      ENSP00000384262.2, OTTHUMP00000160979, ENST00000405413.6, OTTHUMT00000252812
      Conserved Domains (1) summary
      pfam03662
      Location:171370
      Glyco_hydro_79n; Glycosyl hydrolase family 79, N-terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p7 Primary Assembly

      Range
      83292461..83335153 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018915.2 Alternate CHM1_1.1

      Range
      84190339..84232732 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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