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    CASP14 caspase 14 [ Homo sapiens (human) ]

    Gene ID: 23581, updated on 6-Dec-2016
    Official Symbol
    CASP14provided by HGNC
    Official Full Name
    caspase 14provided by HGNC
    Primary source
    HGNC:HGNC:1502
    See related
    Ensembl:ENSG00000105141 MIM:605848; Vega:OTTHUMG00000183205
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    19p13.12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (15049480..15058293)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15160291..15169104)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 1 member 6 Neighboring gene coiled-coil domain containing 105 Neighboring gene olfactory receptor family 1 subfamily I member 1 Neighboring gene synapse defective Rho GTPase homolog 1 Neighboring gene ilvB acetolactate synthase like

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Formation of the cornified envelope, organism-specific biosystem (from REACTOME)
      Formation of the cornified envelope, organism-specific biosystemAs keratinocytes progress towards the upper epidermis, they undergo a unique process of cell death termed cornification (Eckhart et al. 2013). This involves the crosslinking of keratinocyte proteins ...
    • Keratinization, organism-specific biosystem (from REACTOME)
      Keratinization, organism-specific biosystemKeratins are the major structural protein of vertebrate epidermis, constituting up to 85% of a fully differentiated keratinocyte (Fuchs 1995). Keratins belong to a superfamily of intermediate filamen...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC119078, MGC119079

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cysteine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    cysteine-type endopeptidase activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cornification TAS
    Traceable Author Statement
    more info
    PubMed 
    epidermis development TAS
    Traceable Author Statement
    more info
    PubMed 
    keratinization TAS
    Traceable Author Statement
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    keratin filament IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    caspase-14
    Names
    CASP-14
    apoptosis-related cysteine protease
    caspase 14, apoptosis-related cysteine peptidase
    caspase 14, apoptosis-related cysteine protease
    NP_036246.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012114.2NP_036246.1  caspase-14 precursor

      See identical proteins and their annotated locations for NP_036246.1

      Status: REVIEWED

      Source sequence(s)
      AC004699, AK313992, BM840054
      Consensus CDS
      CCDS12323.1
      UniProtKB/Swiss-Prot
      P31944
      UniProtKB/TrEMBL
      B2CIS9
      Related
      ENSP00000393417, OTTHUMP00000271175, ENST00000427043, OTTHUMT00000465663
      Conserved Domains (1) summary
      cd00032
      Location:18242
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      15049480..15058293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527861.1XP_011526163.1  

      See identical proteins and their annotated locations for XP_011526163.1

      Conserved Domains (1) summary
      cl00042
      Location:18181
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      15159760..15168573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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