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    Mdk midkine [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81517, updated on 4-Jun-2017
    Official Symbol
    Mdkprovided by RGD
    Official Full Name
    midkineprovided by RGD
    Primary source
    RGD:69073
    See related
    Ensembl:ENSRNOG00000017560
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    heparin-binding growth factor; involved in early fetal development of the rat adrenal [RGD, Feb 2006]
    Orthologs
    Location:
    3q24
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (80841003..80843895, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (87539671..87542415, complement)

    Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene harbinger transposase derived 1 Neighboring gene autophagy and beclin 1 regulator 1 Neighboring gene ATP synthase lipid-binding protein, mitochondrial-like Neighboring gene cholinergic receptor, muscarinic 4 Neighboring gene uncharacterized LOC103691847 Neighboring gene diacylglycerol kinase zeta Neighboring gene cAMP responsive element binding protein 3-like 1

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    heparin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    adrenal gland development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
     
    behavioral fear response ISO
    Inferred from Sequence Orthology
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cerebellar granular layer development IEA
    Inferred from Electronic Annotation
    more info
     
    cerebellar granular layer development ISO
    Inferred from Sequence Orthology
    more info
     
    cerebral cortex development IEA
    Inferred from Electronic Annotation
    more info
     
    cerebral cortex development ISO
    Inferred from Sequence Orthology
    more info
     
    defecation IEA
    Inferred from Electronic Annotation
    more info
     
    defecation ISO
    Inferred from Sequence Orthology
    more info
     
    dentate gyrus development IEA
    Inferred from Electronic Annotation
    more info
     
    dentate gyrus development ISO
    Inferred from Sequence Orthology
    more info
     
    hippocampus development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of behavior IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of behavior ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to wounding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to wounding ISO
    Inferred from Sequence Orthology
    more info
     
    short-term memory IEA
    Inferred from Electronic Annotation
    more info
     
    short-term memory ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030859.2NP_110486.1  midkine precursor

      See identical proteins and their annotated locations for NP_110486.1

      Status: PROVISIONAL

      Source sequence(s)
      AB025023
      UniProtKB/Swiss-Prot
      Q9R1S9
      UniProtKB/TrEMBL
      A9UMV0
      Conserved Domains (1) summary
      smart00193
      Location:34113
      PTN; Pleiotrophin / midkine family

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

      Range
      80841003..80843895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234593.3XP_006234655.1  midkine isoform X2

      See identical proteins and their annotated locations for XP_006234655.1

      UniProtKB/Swiss-Prot
      Q9R1S9
      UniProtKB/TrEMBL
      A9UMV0
      Conserved Domains (1) summary
      smart00193
      Location:34113
      PTN; Pleiotrophin / midkine family
    2. XM_006234592.2XP_006234654.1  midkine isoform X2

      See identical proteins and their annotated locations for XP_006234654.1

      UniProtKB/Swiss-Prot
      Q9R1S9
      UniProtKB/TrEMBL
      A9UMV0
      Related
      ENSRNOP00000036207.3, ENSRNOT00000033978.3
      Conserved Domains (1) summary
      smart00193
      Location:34113
      PTN; Pleiotrophin / midkine family
    3. XM_006234591.3XP_006234653.1  midkine isoform X1

      Conserved Domains (1) summary
      smart00193
      Location:36115
      PTN; Pleiotrophin / midkine family

    Alternate Rn_Celera

    Genomic

    1. AC_000071.1 Alternate Rn_Celera

      Range
      77104074..77105431 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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