Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Pafah1b1 platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 18472, updated on 5-Dec-2017
    Official Symbol
    Pafah1b1provided by MGI
    Official Full Name
    platelet-activating factor acetylhydrolase, isoform 1b, subunit 1provided by MGI
    Primary source
    MGI:MGI:109520
    See related
    Ensembl:ENSMUSG00000020745 Vega:OTTMUSG00000006184
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lis1; Mdsh; LIS-1; Ms10u; Pafaha; MMS10-U
    Expression
    Ubiquitous expression in CNS E18 (RPKM 47.2), cerebellum adult (RPKM 46.4) and 26 other tissues See more
    Orthologs
    Location:
    11 B5; 11 45.76 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (74673949..74724384, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (74487452..74537886, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108167912 Neighboring gene coiled-coil domain containing 92B Neighboring gene clustered mitochondria (cluA/CLU1) homolog Neighboring gene predicted gene, 40198 Neighboring gene methyltransferase like 16

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC25297

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    dynein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    dynein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    dynein intermediate chain binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphoprotein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acrosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adult locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    ameboidal-type cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    auditory receptor cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    brain morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebral cortex development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebral cortex development ISO
    Inferred from Sequence Orthology
    more info
     
    cerebral cortex neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cochlea development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    corpus callosum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cortical microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of centrosome localization ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of mitotic spindle orientation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    establishment of mitotic spindle orientation ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of planar polarity of embryonic epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hippocampus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    hippocampus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    layer formation in cerebral cortex IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    maintenance of centrosome location IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule cytoskeleton organization involved in establishment of planar polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule organizing center organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    microtubule organizing center organization ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule-based process ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuromuscular process controlling balance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuromuscular process controlling balance ISO
    Inferred from Sequence Orthology
    more info
     
    neuron migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear envelope disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nuclear migration ISO
    Inferred from Sequence Orthology
    more info
     
    osteoclast development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cellular component organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytokine-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    retrograde axonal transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stem cell division ISO
    Inferred from Sequence Orthology
    more info
     
    transmission of nerve impulse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vesicle transport along microtubule IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    astral microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    central region of growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    kinesin complex ISO
    Inferred from Sequence Orthology
    more info
     
    kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    microtubule associated complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule associated complex ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    NOT non-motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stereocilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    platelet-activating factor acetylhydrolase IB subunit alpha
    Names
    PAF acetylhydrolase 45 kDa subunit
    PAF-AH 45 kDa subunit
    PAF-AH alpha
    PAFAH alpha
    Pafaha/Lis1
    lissencephaly-1 protein
    platelet-activating factor acetylhydrolase 1b, regulatory subunit 1
    platelet-activating factor acetylhydrolase, isoform 1b, beta1 subunit
    truncated form platelet-activating factor acetylhydrolase 45kD subunit
    NP_038653.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013625.4NP_038653.1  platelet-activating factor acetylhydrolase IB subunit alpha

      See identical proteins and their annotated locations for NP_038653.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes a functional protein.
      Source sequence(s)
      AK144908, AK168929, BE456911, BQ895724
      Consensus CDS
      CCDS25035.1
      UniProtKB/Swiss-Prot
      P63005
      UniProtKB/TrEMBL
      Q5SW18
      Related
      ENSMUSP00000021091.8, OTTMUSP00000006469, ENSMUST00000021091.14, OTTMUST00000013927
      Conserved Domains (3) summary
      cd00200
      Location:104408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:111148
      7WD40; WD40 repeat [structural motif]
      pfam08513
      Location:935
      LisH; LisH

    RNA

    1. NR_037610.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' exon and is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK147507, AK160764, AK168929, BE456911

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      74673949..74724384 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center