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    Timp3 TIMP metallopeptidase inhibitor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25358, updated on 3-Oct-2017
    Official Symbol
    Timp3provided by RGD
    Official Full Name
    TIMP metallopeptidase inhibitor 3provided by RGD
    Primary source
    RGD:3865
    See related
    Ensembl:ENSRNOG00000004303
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Timp-3
    Summary
    may inhibit metalloendopeptidase activity; may play a role in induction of apoptosis [RGD, Feb 2006]
    Expression
    Biased expression in Kidney (RPKM 1880.2), Lung (RPKM 1045.3) and 8 other tissues See more
    Orthologs
    Location:
    7q13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (23543125..23594170, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (23693364..23744404, complement)

    Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692811 Neighboring gene reticulocalbin-1-like Neighboring gene synapsin III Neighboring gene uncharacterized LOC102551348 Neighboring gene F-box protein 7

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    metalloendopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    metalloendopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    protease binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to organic substance IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to organic substance ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    central nervous system development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    negative regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of catalytic activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of membrane protein ectodomain proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of TRAIL-activated apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of TRAIL-activated apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to amino acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estrogen IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to folic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    tissue regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    basement membrane IEA
    Inferred from Electronic Annotation
    more info
     
    basement membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    colocalizes_with extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    proteinaceous extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    metalloproteinase inhibitor 3
    Names
    tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)
    tissue inhibitor of metalloproteinases 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012886.2NP_037018.2  metalloproteinase inhibitor 3 precursor

      See identical proteins and their annotated locations for NP_037018.2

      Status: PROVISIONAL

      Source sequence(s)
      BC097335
      UniProtKB/TrEMBL
      Q4V8L0
      Related
      ENSRNOP00000005746.3, ENSRNOT00000005746.5
      Conserved Domains (1) summary
      cd03585
      Location:24200
      NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

      Range
      23543125..23594170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241162.3XP_006241224.1  metalloproteinase inhibitor 3 isoform X1

      See identical proteins and their annotated locations for XP_006241224.1

      UniProtKB/TrEMBL
      Q4V8L0
      Conserved Domains (1) summary
      cd03585
      Location:24200
      NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

    Alternate Rn_Celera

    Genomic

    1. AC_000075.1 Alternate Rn_Celera

      Range
      14761240..14810915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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