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    Bub1b BUB1B, mitotic checkpoint serine/threonine kinase [ Mus musculus (house mouse) ]

    Gene ID: 12236, updated on 19-May-2018
    Official Symbol
    Bub1bprovided by MGI
    Official Full Name
    BUB1B, mitotic checkpoint serine/threonine kinaseprovided by MGI
    Primary source
    MGI:MGI:1333889
    See related
    Ensembl:ENSMUSG00000040084 Vega:OTTMUSG00000015367
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BUBR1; AU045529
    Expression
    Biased expression in CNS E11.5 (RPKM 30.8), liver E14 (RPKM 21.6) and 14 other tissues See more
    Orthologs
    See Bub1b in Genome Data Viewer
    Location:
    2; 2 E5
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (118598202..118641592)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (118423947..118467328)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene BCL2 modifying factor Neighboring gene eukaryotic translation initiation factor 5A pseudogene Neighboring gene p21 (RAC1) activated kinase 6 Neighboring gene ankyrin repeat domain 63

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC36092

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    meiotic sister chromatid cohesion, centromeric IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    metaphase/anaphase transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mitotic spindle assembly checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein localization to chromosome, centromeric region IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    condensed chromosome kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    condensed chromosome outer kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed chromosome outer kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    condensed nuclear chromosome kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    condensed nuclear chromosome kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    mitotic checkpoint serine/threonine-protein kinase BUB1 beta
    Names
    MAD3/BUB1-related protein kinase
    budding uninhibited by benzimidazoles 1 beta
    budding uninhibited by benzimidazoles 1 homolog, beta
    mitotic checkpoint kinase MAD3L
    NP_033903.2
    XP_006498685.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009773.3NP_033903.2  mitotic checkpoint serine/threonine-protein kinase BUB1 beta

      See identical proteins and their annotated locations for NP_033903.2

      Status: VALIDATED

      Source sequence(s)
      AK133909, AV315589, BU054510, BY013487
      Consensus CDS
      CCDS16579.1
      UniProtKB/Swiss-Prot
      Q9Z1S0
      UniProtKB/TrEMBL
      Q3UZD6
      Related
      ENSMUSP00000037126.7, OTTMUSP00000016369, ENSMUST00000038341.7, OTTMUST00000036418
      Conserved Domains (3) summary
      COG0515
      Location:825909
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      pfam08311
      Location:51172
      Mad3_BUB1_I; Mad3/BUB1 homology region 1
      cl21453
      Location:7391035
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      118598202..118641592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498622.3XP_006498685.1  mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform X1

      Conserved Domains (2) summary
      pfam08311
      Location:51172
      Mad3_BUB1_I; Mad3/BUB1 homology region 1
      cl21453
      Location:7401036
      PKc_like; Protein Kinases, catalytic domain
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