Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Eef2 eukaryotic translation elongation factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29565, updated on 4-Jun-2017
    Official Symbol
    Eef2provided by RGD
    Official Full Name
    eukaryotic translation elongation factor 2provided by RGD
    Primary source
    RGD:61979
    See related
    Ensembl:ENSRNOG00000020266
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ef-2
    Summary
    catalyzes the translocation of peptidyl-tRNA from the ribosomal A site to the P site in translational elongation [RGD, Feb 2006]
    Orthologs
    Location:
    7q11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11401501..11406771, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (11568907..11574177, complement)

    Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene nicotinamide riboside kinase 2 Neighboring gene death-associated protein kinase 3 Neighboring gene uncharacterized LOC102553232 Neighboring gene protein inhibitor of activated STAT, 4

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    5S rRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cadherin binding IEA
    Inferred from Electronic Annotation
    more info
     
    cadherin binding ISO
    Inferred from Sequence Orthology
    more info
     
    p53 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ribosome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    translation elongation factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to brain-derived neurotrophic factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    glial cell proliferation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    hematopoietic progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytoplasmic translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to endoplasmic reticulum stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to folic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ischemia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    skeletal muscle cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    skeletal muscle contraction IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    translational elongation ISO
    Inferred from Sequence Orthology
    more info
     
    translational elongation TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    aggresome IEA
    Inferred from Electronic Annotation
    more info
     
    aggresome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    NOT nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    polysomal ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    polysome ISO
    Inferred from Sequence Orthology
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017245.2NP_058941.1  elongation factor 2

      See identical proteins and their annotated locations for NP_058941.1

      Status: PROVISIONAL

      Source sequence(s)
      BC066661
      UniProtKB/Swiss-Prot
      P05197
      Related
      ENSRNOP00000041821.3, ENSRNOT00000047450.3
      Conserved Domains (6) summary
      cd01885
      Location:20233
      EF2; Elongation Factor 2 (EF2) in archaea and eukarya
      cd01681
      Location:574746
      aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...
      cd04096
      Location:742821
      eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...
      PTZ00416
      Location:1858
      PTZ00416; elongation factor 2; Provisional
      cd03700
      Location:394488
      EF2_snRNP_like_II; Domain II of elongation factor 2 and C-terminal domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein
      cd16261
      Location:503574
      EF2_snRNP_III; Domain III of Elongation Factor 2 (EF2)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

      Range
      11401501..11406771 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000075.1 Alternate Rn_Celera

      Range
      6721131..6726401 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center