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    EGR1 early growth response 1 [ Homo sapiens (human) ]

    Gene ID: 1958, updated on 20-May-2018
    Official Symbol
    EGR1provided by HGNC
    Official Full Name
    early growth response 1provided by HGNC
    Primary source
    HGNC:HGNC:3238
    See related
    Ensembl:ENSG00000120738 MIM:128990; Vega:OTTHUMG00000129197
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TIS8; AT225; G0S30; NGFI-A; ZNF225; KROX-24; ZIF-268
    Summary
    The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]
    Expression
    Ubiquitous expression in ovary (RPKM 449.0), thyroid (RPKM 344.9) and 23 other tissues See more
    Orthologs
    See EGR1 in Genome Data Viewer
    Location:
    5q31.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (138465492..138469315)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (137801181..137805004)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene lysine demethylase 3B Neighboring gene receptor accessory protein 2 Neighboring gene ribosomal protein L7 pseudogene 19 Neighboring gene eukaryotic translation termination factor 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The gene expression of early growth response 1 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed
    tat HIV-1 Tat-induced upregulation and phosphorylation of STAT3 expression results in increased GFAP, Egr-1, and p300 transcription and protein expression in both Tat-expressing astrocytes, and HIV-infected astrocytes PubMed
    tat HIV-1 Tat increases Egr-1 expression in human astrocytoma cells by transactivating the Egr-1 promoter and involving specific serum response elements within the promoter PubMed
    tat HIV-1 Tat decreases the levels of Egr-1 and p35 expression in nerve growth factor (NGF)-treated neural cells PubMed
    tat HIV-1-Tat-mediated upregulation of platelet-derived growth factor (PDGF) B chain in astrocytes is regulated by activation of ERK1/2 and JNK MAPK signaling pathways and the downstream transcription factor early growth response 1 (Egr1) PubMed
    tat HIV-1 Tat upregulates EGR1 expression in Tat-infected Jurkat T cells PubMed
    tat HIV-1 Tat-induced upregulation of p300 occurs at the transcriptional level through the cis-acting elements of early growth response 1 (egr-1) within its promoter PubMed
    tat HIV-1 Tat binds to Egr-1, an interaction that is mediated through Tat amino acids 30-40 PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to gamma radiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to heparin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to interleukin-8 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to mycophenolic acid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    estrous cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glomerular mesangial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    interleukin-1-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of chemokine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of glomerular metanephric mesangial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of hormone biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interleukin-1 beta biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of neuron death ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of tau-protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of progesterone biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of protein sumoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    response to glucose IEA
    Inferred from Electronic Annotation
    more info
     
    response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to insulin IEA
    Inferred from Electronic Annotation
    more info
     
    response to ischemia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    skeletal muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    type I interferon signaling pathway TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    early growth response protein 1
    Names
    EGR-1
    nerve growth factor-induced protein A
    transcription factor ETR103
    transcription factor Zif268
    zinc finger protein 225
    zinc finger protein Krox-24

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021374.1 RefSeqGene

      Range
      5001..8824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001964.2NP_001955.1  early growth response protein 1

      See identical proteins and their annotated locations for NP_001955.1

      Status: REVIEWED

      Source sequence(s)
      X52541
      Consensus CDS
      CCDS4206.1
      UniProtKB/Swiss-Prot
      P18146
      UniProtKB/TrEMBL
      Q546S1
      Related
      ENSP00000239938.4, OTTHUMP00000159483, ENST00000239938.4, OTTHUMT00000251274
      Conserved Domains (5) summary
      sd00017
      Location:340362
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam11914
      Location:447530
      DUF3432; Domain of unknown function (DUF3432)
      pfam00096
      Location:338362
      zf-C2H2; Zinc finger, C2H2 type
      pfam11928
      Location:135209
      DUF3446; Domain of unknown function (DUF3446)
      pfam13465
      Location:382407
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

      Range
      138465492..138469315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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