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    Lasp1 LIM and SH3 protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 16796, updated on 6-Aug-2017
    Official Symbol
    Lasp1provided by MGI
    Official Full Name
    LIM and SH3 protein 1provided by MGI
    Primary source
    MGI:MGI:109656
    See related
    Ensembl:ENSMUSG00000038366 Vega:OTTMUSG00000002777
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Def-4; SH3P6; AA408629; Tg(Col1a1-lacZ)1Ngma
    Orthologs
    Location:
    11 D; 11 61.1 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (97799005..97838765)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (97660986..97700078)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA cysteine 56 (anticodon GCA) Neighboring gene nuclear encoded tRNA cysteine 51 (anticodon GCA) Neighboring gene RIKEN cDNA B230217C12 gene Neighboring gene F-box protein 47

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cadherin binding ISO
    Inferred from Sequence Orthology
    more info
     
    ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cortical actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    LIM and SH3 domain protein 1
    Names
    LASP-1
    MLN 50
    Tg(11Col1a1)NG
    metastatic lymph node gene 50 protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010688.4NP_034818.1  LIM and SH3 domain protein 1

      See identical proteins and their annotated locations for NP_034818.1

      Status: PROVISIONAL

      Source sequence(s)
      AL596446
      Consensus CDS
      CCDS25332.1
      UniProtKB/Swiss-Prot
      Q61792
      UniProtKB/TrEMBL
      Q543N3
      Related
      ENSMUSP00000042123.5, OTTMUSP00000002658, ENSMUST00000043843.11, OTTMUST00000005566
      Conserved Domains (3) summary
      smart00227
      Location:98128
      NEBU; The Nebulin repeat is present also in Las1
      cd09447
      Location:557
      LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)
      cd11934
      Location:205263
      SH3_Lasp1_C; C-terminal Src Homology 3 domain of LIM and SH3 domain protein 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      97799005..97838765
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532341.1XP_006532404.1  LIM and SH3 domain protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006532404.1

      UniProtKB/Swiss-Prot
      Q61792
      UniProtKB/TrEMBL
      Q543N3
      Conserved Domains (3) summary
      smart00227
      Location:98128
      NEBU; The Nebulin repeat is present also in Las1
      cd09447
      Location:557
      LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)
      cd11934
      Location:205263
      SH3_Lasp1_C; C-terminal Src Homology 3 domain of LIM and SH3 domain protein 1
    2. XM_006532342.1XP_006532405.1  LIM and SH3 domain protein 1 isoform X2

      Related
      ENSMUSP00000123050.1, OTTMUSP00000002668, ENSMUST00000148280.2, OTTMUST00000005576
      Conserved Domains (3) summary
      smart00227
      Location:6292
      NEBU; The Nebulin repeat is present also in Las1
      cd11934
      Location:169227
      SH3_Lasp1_C; C-terminal Src Homology 3 domain of LIM and SH3 domain protein 1
      cl02475
      Location:121
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
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